LEVODOPA

Search structure
Trade Names:
Synonyms:
Status: Approved (1970)
Entry Type: Small molecule
Molecule Category: Parent
ATC: N04BA01
UNII: 46627O600J

Structure
InChI Key WTDRDQBEARUVNC-LURJTMIESA-N
Smile N[C@@H](Cc1ccc(O)c(O)c1)C(=O)O
InChI
InChI=1S/C9H11NO4/c10-6(9(13)14)3-5-1-2-7(11)8(12)4-5/h1-2,4,6,11-12H,3,10H2,(H,13,14)/t6-/m0/s1

Physicochemical Descriptors

Property Name Value
Molecular Formula C9H11NO4
Molecular Weight 197.19
AlogP 0.05
Hydrogen Bond Acceptor 4.0
Hydrogen Bond Donor 4.0
Number of Rotational Bond 3.0
Polar Surface Area 103.78
Molecular species ZWITTERION
Aromatic Rings 1.0
Heavy Atoms 14.0

Pharmacology

Action Mechanism of Action Reference
AGONIST Dopamine D3 receptor agonist PubMed PubMed PubMed DailyMed Wikipedia
Targets EC50(nM) IC50(nM) Kd(nM) Ki(nM) Inhibition(%)
Transporter Electrochemical transporter SLC superfamily of solute carriers SLC03 and SLC07 families of heteromeric amino acid transporters (HATs) SLC07 Cationic amino acid transporter/glycoprotein-associated family
- 100000 - - -
Transporter Electrochemical transporter SLC superfamily of solute carriers SLC21/SLCO family of organic anion transporting polypeptides
- - - - 86
Transporter Electrochemical transporter SLC superfamily of solute carriers SLC22 family of organic cation and anion transporters
- - - - 22
Unclassified protein
- - - - 62-99

Indications

Mesh Heading Maximum Phase Mesh ID Reference
Stroke 3 D020521 ClinicalTrials
Restless Legs Syndrome 3 D012148 ClinicalTrials
Amblyopia 3 D000550 ClinicalTrials
Child Development Disorders, Pervasive 2 D002659 ClinicalTrials
Pain 2 D010146 ClinicalTrials
Albinism 2 D000417 ClinicalTrials
Cocaine-Related Disorders 2 D019970 ClinicalTrials
Schizophrenia 2 D012559 ClinicalTrials
Macular Degeneration 2 D008268 ClinicalTrials
Albinism, Oculocutaneous 2 D016115 ClinicalTrials
Angelman Syndrome 2 D017204 ClinicalTrials
Retinitis Pigmentosa 2 D012174 ClinicalTrials
Aphasia 2 D001037 ClinicalTrials
Stress Disorders, Post-Traumatic 2 D013313 ClinicalTrials
Back Pain 2 D001416 ClinicalTrials
Spinal Cord Injuries 2 D013119 ClinicalTrials
Hypotension, Orthostatic 1 D007024 ClinicalTrials
Tobacco Use Disorder 1 D014029 ClinicalTrials
Asthma 1 D001249 ClinicalTrials
Tourette Syndrome 1 D005879 ClinicalTrials
Amyotrophic Lateral Sclerosis 1 D000690 ClinicalTrials
Brain Injuries 0 D001930 ClinicalTrials

Related Entries

Mixture
Mixture

Adverse Reactions

SOC By Demographic Distribution
System Organ Classification (SOC)
Relative Frequency (%)
Respiratory, thoracic and mediastinal disorders
29.96
Injury, poisoning and procedural complications
16.74
General disorders and administration site conditions
15.25
Nervous system disorders
8.32
Gastrointestinal disorders
7.68
Product issues
5.65
Psychiatric disorders
4.58
Cardiac disorders
3.41

Cross References

Resources Reference
CAS NUMBER 59-92-7
ChEBI 57504
ChEMBL CHEMBL1009
DrugBank DB01235
DrugCentral 1567
EPA CompTox DTXSID9023209
FDA SRS 46627O600J
Human Metabolome Database HMDB0000181
Guide to Pharmacology 3639
KEGG C00355
PDB DAH
PharmGKB PA450213
PubChem 6047
SureChEMBL SCHEMBL22655
ZINC ZINC000000895199
CONTENTS