LINDANE

Search structure
Trade Names:
Synonyms:
Status: Approved (1974)
Entry Type: Small molecule
Molecule Category: UNKNOWN
ATC: P03AB02
UNII: 59NEE7PCAB

Structure
InChI Key JLYXXMFPNIAWKQ-GNIYUCBRSA-N
Smile Cl[C@H]1[C@H](Cl)[C@@H](Cl)[C@@H](Cl)[C@H](Cl)[C@H]1Cl
InChI
InChI=1S/C6H6Cl6/c7-1-2(8)4(10)6(12)5(11)3(1)9/h1-6H/t1-,2-,3-,4+,5+,6+

Physicochemical Descriptors

Property Name Value
Molecular Formula C6H6Cl6
Molecular Weight 290.83
AlogP 3.64
Hydrogen Bond Acceptor 0.0
Hydrogen Bond Donor 0.0
Number of Rotational Bond 0.0
Polar Surface Area 0.0
Molecular species None
Aromatic Rings 0.0
Heavy Atoms 12.0

Pharmacology

Action Mechanism of Action Reference
NEGATIVE ALLOSTERIC MODULATOR GABA-A receptor negative allosteric modulator PubMed Wikipedia
Targets EC50(nM) IC50(nM) Kd(nM) Ki(nM) Inhibition(%)
Ion channel Ligand-gated ion channel GABA-A receptor
- 1 - - -
Transcription factor Nuclear receptor Nuclear hormone receptor subfamily 3 Nuclear hormone receptor subfamily 3 group C Nuclear hormone receptor subfamily 3 group C member 4
- 40738 - - -
Transporter Electrochemical transporter SLC superfamily of solute carriers SLC21/SLCO family of organic anion transporting polypeptides
- - - - 80

Indications

Mesh Heading Maximum Phase Mesh ID Reference
Lice Infestations 2 D010373 ClinicalTrials

Adverse Reactions

SOC By Demographic Distribution
System Organ Classification (SOC)
Relative Frequency (%)
General disorders and administration site conditions
60.0
Skin and subcutaneous tissue disorders
40.0

Cross References

Resources Reference
CAS NUMBER 58-89-9
ChEBI 32888
ChEMBL CHEMBL15891
DrugBank DB00431
DrugCentral 1583
EPA CompTox DTXSID2020686
FDA SRS 59NEE7PCAB
Human Metabolome Database HMDB0014575
KEGG C07075
SureChEMBL SCHEMBL25895
ZINC ZINC00001621
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