LOMUSTINE

Search structure
Trade Names:
Synonyms:
Status: Approved (1976)
Entry Type: Small molecule
Molecule Category: UNKNOWN
ATC: L01AD02
UNII: 7BRF0Z81KG

Structure
InChI Key GQYIWUVLTXOXAJ-UHFFFAOYSA-N
Smile O=NN(CCCl)C(=O)NC1CCCCC1
InChI
InChI=1S/C9H16ClN3O2/c10-6-7-13(12-15)9(14)11-8-4-2-1-3-5-8/h8H,1-7H2,(H,11,14)

Physicochemical Descriptors

Property Name Value
Molecular Formula C9H16ClN3O2
Molecular Weight 233.7
AlogP 2.25
Hydrogen Bond Acceptor 3.0
Hydrogen Bond Donor 1.0
Number of Rotational Bond 4.0
Polar Surface Area 61.77
Molecular species NEUTRAL
Aromatic Rings 0.0
Heavy Atoms 15.0

Pharmacology

Action Mechanism of Action Reference
INHIBITOR DNA inhibitor FDA

Indications

Mesh Heading Maximum Phase Mesh ID Reference
Brain Neoplasms 4 D001932 ClinicalTrials
Multiple Myeloma 3 D009101 ClinicalTrials
Astrocytoma 3 D001254 ClinicalTrials
Medulloblastoma 3 D008527 ClinicalTrials
Glioblastoma 3 D005909 ClinicalTrials
Leukemia, Myeloid, Acute 3 D015470 ClinicalTrials
Central Nervous System Neoplasms 3 D016543 ClinicalTrials
Lymphoma, AIDS-Related 2 D016483 ClinicalTrials
Lymphoma 2 D008223 ClinicalTrials
Melanoma 2 D008545 ClinicalTrials
Melanoma 2 D008545 ClinicalTrials
Lung Neoplasms 2 D008175 ClinicalTrials
Lung Neoplasms 2 D008175 ClinicalTrials
Bone Neoplasms 1 D001859 ClinicalTrials
Glioma 1 D005910 ClinicalTrials
Sarcoma 1 D012509 ClinicalTrials
Neoplasm Metastasis 1 D009362 ClinicalTrials
Kidney Neoplasms 1 D007680 ClinicalTrials
Breast Neoplasms 1 D001943 ClinicalTrials
Glioma 1 D005910 ClinicalTrials

Related Entries

MCS

Adverse Reactions

SOC By Demographic Distribution
System Organ Classification (SOC)
Relative Frequency (%)
General disorders and administration site conditions
11.88
Nervous system disorders
11.39
Neoplasms benign, malignant and unspecified (incl cysts and polyps)
7.43
Injury, poisoning and procedural complications
6.93
Skin and subcutaneous tissue disorders
6.93
Infections and infestations
6.44
Investigations
6.44
Blood and lymphatic system disorders
5.94
Vascular disorders
5.45
Eye disorders
4.46
Psychiatric disorders
4.46
Respiratory, thoracic and mediastinal disorders
4.46
Gastrointestinal disorders
3.96
Immune system disorders
3.47
Hepatobiliary disorders
2.97
Metabolism and nutrition disorders
2.97
Musculoskeletal and connective tissue disorders
2.48

Cross References

Resources Reference
CAS NUMBER 13010-47-4
ChEBI 6520
ChEMBL CHEMBL514
DrugBank DB01206
DrugCentral 1596
EPA CompTox DTXSID2023222
FDA SRS 7BRF0Z81KG
Human Metabolome Database HMDB0015337
Guide to Pharmacology 7214
KEGG C07079
PharmGKB PA164749407
PubChem 3950
SureChEMBL SCHEMBL3995
ZINC ZINC000003831006
CONTENTS