| Trade Names: | |
| Synonyms: | |
| Status: | Approved (1998) |
| Entry Type: | Small molecule |
| Molecule Category: | Salt Prodrug |
| UNII: | YEH1EZ96K6 |
| Parent Compound: | LOTEPREDNOL |
Structure
| InChI Key | DMKSVUSAATWOCU-HROMYWEYSA-N |
|---|---|
| Smile | |
| InChI |
|
Physicochemical Descriptors
| Property Name | Value |
|---|---|
| Molecular Formula | C24H31ClO7 |
| Molecular Weight | 466.96 |
| AlogP | 3.92 |
| Hydrogen Bond Acceptor | 7.0 |
| Hydrogen Bond Donor | 1.0 |
| Number of Rotational Bond | 4.0 |
| Polar Surface Area | 99.13 |
| Molecular species | NEUTRAL |
| Aromatic Rings | 0.0 |
| Heavy Atoms | 32.0 |
Pharmacology
| Targets | EC50(nM) | IC50(nM) | Kd(nM) | Ki(nM) | Inhibition(%) | |
|---|---|---|---|---|---|---|
|
Transporter
Primary active transporter
ATP-binding cassette
ABCB subfamily
|
- | 40400 | - | - | - | |
|
Transporter
Primary active transporter
ATP-binding cassette
ABCC subfamily
|
- | 15520 | - | - | - |
Indications
| Mesh Heading | Maximum Phase | Mesh ID | Reference |
|---|---|---|---|
| Cataract | 3 | D002386 | ClinicalTrials |
| Blepharitis | 2 | D001762 | ClinicalTrials |
| Eye Pain | 1 | D058447 | ClinicalTrials |
Related Entries
Adverse Reactions
System Organ Classification (SOC)
Cross References
| Resources | Reference |
|---|---|
| CAS NUMBER | 82034-46-6 |
| ChEBI | 31784 |
| ChEMBL | CHEMBL1200865 |
| DrugBank | DB14596 |
| DrugCentral | 1611 |
| EPA CompTox | DTXSID2046468 |
| FDA SRS | YEH1EZ96K6 |
| Guide to Pharmacology | 7085 |
| PharmGKB | PA164764569 |
| PubChem | 444025 |
| SureChEMBL | SCHEMBL23907 |
| ZINC | ZINC000003920673 |
CONTENTS