MANNITOL

Search structure


Trade Names:	ARIDOL ARIDOL KIT MANNITOL 10% MANNITOL 10% IN PLASTIC CONTAINER MANNITOL 10% W/ DEXTROSE 5% IN DISTILLED WATER MANNITOL 15% MANNITOL 15% IN PLASTIC CONTAINER MANNITOL 15% W/ DEXTROSE 5% IN SODIUM CHLORIDE 0.45% MANNITOL 20% MANNITOL 20% IN PLASTIC CONTAINER MANNITOL 25% MANNITOL 5% MANNITOL 5% IN PLASTIC CONTAINER MANNITOL 5% W/ DEXTROSE 5% IN SODIUM CHLORIDE 0.12% OSMITROL 10% IN WATER OSMITROL 10% IN WATER IN PLASTIC CONTAINER OSMITROL 15% IN WATER OSMITROL 15% IN WATER IN PLASTIC CONTAINER OSMITROL 20% IN WATER OSMITROL 20% IN WATER IN PLASTIC CONTAINER OSMITROL 5% IN WATER OSMITROL 5% IN WATER IN PLASTIC CONTAINER RESECTISOL RESECTISOL IN PLASTIC CONTAINER
Synonyms:	Alexitol sodium Aridol kit Bronchitol Cordycepic acid Crystalline mannitol extra-fine Crystalline mannitol fine Crystalline mannitol standard Diosmol D-(-)-mannitol D-mannitol E-421 E421 INS-421 INS NO.421 Isomalt impurity, mannitol- Manna sugar Mannite Mannitol Mannitol 200 Mannitol 2080 Mannitol 25 Mannitol 300 Mannitol 35 Mannitol 60 Mannitol, d- Mannitol m300 Mannitolum Mannogem 2080 NSC-407017 Osmitrol Pearlitol 160 c Pearlitol 200 sd Pearlitol 25 c Pearlitol 300 dc Pearlitol 50 c Resectisol
Status:	Approved
Entry Type:	Small molecule
Molecule Category:	Parent
ATC:	A06AD16
UNII:	3OWL53L36A

Structure


InChI Key	FBPFZTCFMRRESA-KVTDHHQDSA-N
Smile	OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO
InChI	InChI=1S/C6H14O6/c7-1-3(9)5(11)6(12)4(10)2-8/h3-12H,1-2H2/t3-,4-,5-,6-/m1/s1

Physicochemical Descriptors

Property Name	Value
Molecular Formula	C6H14O6
Molecular Weight	182.17
AlogP	-3.59
Hydrogen Bond Acceptor	6.0
Hydrogen Bond Donor	6.0
Number of Rotational Bond	5.0
Polar Surface Area	121.38
Molecular species	NEUTRAL
Aromatic Rings	0.0
Heavy Atoms	12.0

Pharmacology

Targets	EC50(nM)	IC50(nM)	Kd(nM)	Ki(nM)	Inhibition(%)
Enzyme Protease Serine protease Serine protease PA clan Serine protease S1A subfamily	-	-	-	-	29
Transporter Electrochemical transporter SLC superfamily of solute carriers SLC22 family of organic cation and anion transporters	-	-	-	-

Indications

Mesh Heading	Maximum Phase	Mesh ID	Reference
Constipation	4	D003248	ClinicalTrials
Brain Edema	4	D001929	ClinicalTrials
Asthma	4	D001249	ClinicalTrials
Cystic Fibrosis	4	D003550	ClinicalTrials
Shock, Septic	3	D012772	ClinicalTrials
Fetal Hypoxia	3	D005311	ClinicalTrials
Intracranial Hypertension	3	D019586	ClinicalTrials
Ciguatera Poisoning	3	D036841	ClinicalTrials
Respiratory Sounds	3	D012135	ClinicalTrials
Brain Injuries	3	D001930	ClinicalTrials
Kidney Neoplasms	3	D007680	ClinicalTrials
Hernias, Diaphragmatic, Congenital	3	D065630	ClinicalTrials
Coronary Disease	3	D003327	ClinicalTrials
Malaria	3	D008288	ClinicalTrials
Bronchiectasis	3	D001987	ClinicalTrials
Severe Acute Respiratory Syndrome	2	D045169	ClinicalTrials
Stroke	2	D020521	ClinicalTrials
Hypotension	2	D007022	ClinicalTrials
Opioid-Related Disorders	2	D009293	ClinicalTrials
Pulpitis	2	D011671	ClinicalTrials
Sleep Apnea, Obstructive	2	D020181	ClinicalTrials
Osteoarthritis	2	D010003	ClinicalTrials
Oligodendroglioma	1	D009837	ClinicalTrials
Leukemia, Myelogenous, Chronic, BCR-ABL Positive	1	D015464	ClinicalTrials
Neuralgia, Postherpetic	1	D051474	ClinicalTrials
Diabetic Neuropathies	1	D003929	ClinicalTrials
Glioblastoma	1	D005909	ClinicalTrials
Pain	1	D010146	ClinicalTrials
Wounds and Injuries	1	D014947	ClinicalTrials
Pulmonary Disease, Chronic Obstructive	1	D029424	ClinicalTrials
Central Nervous System Neoplasms	1	D016543	ClinicalTrials
Brain Neoplasms	1	D001932	ClinicalTrials

Related Entries

Mixture

Side Effects from Label

Side Effects (PT)

Side effects	Relative Frequency (%)	Labels
Respiratory, thoracic and mediastinal disorders Cough	7.9
Nervous system disorders Headache	5.64
Cardiac disorders Dyspnoea	5.0
Cardiac disorders Chest discomfort	4.29
Cardiac disorders Chest pain	4.29
Cardiac disorders Dizziness	3.1
Respiratory, thoracic and mediastinal disorders Laryngeal pain	2.39
Respiratory, thoracic and mediastinal disorders Cough	1.9
Gastrointestinal disorders Nausea	1.82
Gastrointestinal disorders Throat irritation	1.82
Respiratory, thoracic and mediastinal disorders Cough	1.63
Infections and infestations Nasopharyngitis	1.53
Respiratory, thoracic and mediastinal disorders Rhinorrhoea	1.53
Cardiac disorders Dyspnoea	1.43
Respiratory, thoracic and mediastinal disorders Wheezing	1.43
Cardiac disorders Chest discomfort	1.24
Cardiac disorders Chest pain	1.24
Nervous system disorders Headache	0.952
Respiratory, thoracic and mediastinal disorders Wheezing	0.765
Gastrointestinal disorders Retching	0.574
Cardiac disorders Dizziness	0.478
Gastrointestinal disorders Throat irritation	0.238

Adverse Reactions

SOC By Demographic Distribution

System Organ Classification (SOC)

	Relative Frequency (%)
General disorders and administration site conditions	15.34
Metabolism and nutrition disorders	13.86
Vascular disorders	11.68
Cardiac disorders	9.19
Nervous system disorders	8.8
Respiratory, thoracic and mediastinal disorders	6.67
Injury, poisoning and procedural complications	5.01
Immune system disorders	4.58
Renal and urinary disorders	3.83
Musculoskeletal and connective tissue disorders	3.66
Investigations	3.4
Ear and labyrinth disorders	3.05
Infections and infestations	2.44
Gastrointestinal disorders	2.18
Psychiatric disorders	2.18

Cross References

Resources	Reference
CAS NUMBER	69-65-8
ChEBI	16899
ChEMBL	CHEMBL689
DrugBank	DB00742
DrugCentral	935
EPA CompTox	DTXSID30858955
FDA SRS	3OWL53L36A
Human Metabolome Database	HMDB0000765
KEGG	C00392
PDB	MTL
PubChem	6251
SureChEMBL	SCHEMBL919
ZINC	ZINC000002041302

CONTENTS


Active Pharmaceutical Ingredients (APIs) Scaffolds	Exact Similarity SubStructure	Threshold (%) >= 70