METOCLOPRAMIDE HYDROCHLORIDE

Search structure
Trade Names:
Synonyms:
Status: Approved (1979)
Entry Type: Small molecule
Molecule Category: Salt
UNII: W1792A2RVD
Parent Compound: METOCLOPRAMIDE

Structure
InChI Key RVFUNJWWXKCWNS-UHFFFAOYSA-N
Smile CCN(CC)CCNC(=O)c1cc(Cl)c(N)cc1OC.Cl
InChI
InChI=1S/C14H22ClN3O2.ClH/c1-4-18(5-2)7-6-17-14(19)10-8-11(15)12(16)9-13(10)20-3;/h8-9H,4-7,16H2,1-3H3,(H,17,19);1H

Physicochemical Descriptors

Property Name Value
Molecular Formula C14H25Cl2N3O3
Molecular Weight 354.28
AlogP 2.0
Hydrogen Bond Acceptor 4.0
Hydrogen Bond Donor 2.0
Number of Rotational Bond 7.0
Polar Surface Area 67.59
Molecular species BASE
Aromatic Rings 1.0
Heavy Atoms 20.0

Pharmacology

Action Mechanism of Action Reference
ANTAGONIST Dopamine D2 receptor antagonist
Targets EC50(nM) IC50(nM) Kd(nM) Ki(nM) Inhibition(%)
Enzyme Transferase
- - - - 17.62
Epigenetic regulator Eraser Histone deacetylase HDAC class IIb
- - - - -10.99-4.13

Indications

Mesh Heading Maximum Phase Mesh ID Reference

Related Entries

Parent

Adverse Reactions

SOC By Demographic Distribution
System Organ Classification (SOC)
Relative Frequency (%)
Nervous system disorders
37.53
General disorders and administration site conditions
9.07
Psychiatric disorders
8.66
Gastrointestinal disorders
5.59
Cardiac disorders
4.68
Injury, poisoning and procedural complications
4.51
Musculoskeletal and connective tissue disorders
4.43
Immune system disorders
3.87
Respiratory, thoracic and mediastinal disorders
3.44
Vascular disorders
3.17
Skin and subcutaneous tissue disorders
2.57
Metabolism and nutrition disorders
2.33
Investigations
2.21

Cross References

Resources Reference
ChEBI 6899
ChEMBL CHEMBL1200940
FDA SRS W1792A2RVD
Guide to Pharmacology 241
KEGG C07868
PubChem 43833342
SureChEMBL SCHEMBL133509
ZINC ZINC01530716
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