METYROSINE

Search structure
Trade Names:
Synonyms:
Status: Approved (1979)
Entry Type: Small molecule
Molecule Category: UNKNOWN
UNII: DOQ0J0TPF7

Structure
InChI Key NHTGHBARYWONDQ-JTQLQIEISA-N
Smile C[C@](N)(Cc1ccc(O)cc1)C(=O)O
InChI
InChI=1S/C10H13NO3/c1-10(11,9(13)14)6-7-2-4-8(12)5-3-7/h2-5,12H,6,11H2,1H3,(H,13,14)/t10-/m0/s1

Physicochemical Descriptors

Property Name Value
Molecular Formula C10H13NO3
Molecular Weight 195.22
AlogP 0.74
Hydrogen Bond Acceptor 3.0
Hydrogen Bond Donor 3.0
Number of Rotational Bond 3.0
Polar Surface Area 83.55
Molecular species ZWITTERION
Aromatic Rings 1.0
Heavy Atoms 14.0

Pharmacology

Action Mechanism of Action Reference
INHIBITOR Tyrosine 3-hydroxylase inhibitor DailyMed
Targets EC50(nM) IC50(nM) Kd(nM) Ki(nM) Inhibition(%)
Transporter Electrochemical transporter SLC superfamily of solute carriers SLC21/SLCO family of organic anion transporting polypeptides
- - - - 64

Indications

Mesh Heading Maximum Phase Mesh ID Reference
Psychotic Disorders 2 D011618 ClinicalTrials

Related Entries

MCS

Adverse Reactions

SOC By Demographic Distribution
System Organ Classification (SOC)
Relative Frequency (%)
Injury, poisoning and procedural complications
26.73
Psychiatric disorders
20.79
General disorders and administration site conditions
14.85
Gastrointestinal disorders
13.86
Skin and subcutaneous tissue disorders
7.92
Nervous system disorders
3.96
Neoplasms benign, malignant and unspecified (incl cysts and polyps)
2.97

Cross References

Resources Reference
CAS NUMBER 672-87-7
ChEBI 6912
ChEMBL CHEMBL1200862
DrugBank DB00765
DrugCentral 1792
EPA CompTox DTXSID6023315
FDA SRS DOQ0J0TPF7
Human Metabolome Database HMDB0014903
Guide to Pharmacology 6956
KEGG C07921
PharmGKB PA450487
PubChem 441350
SureChEMBL SCHEMBL50398
ZINC ZINC000000000693
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