MIDODRINE HYDROCHLORIDE

Search structure
Trade Names:
Synonyms:
Status: Approved (1996)
Entry Type: Small molecule
Molecule Category: Salt Prodrug
UNII: 59JV96YTXV
Parent Compound: MIDODRINE

Structure
InChI Key MGCQZNBCJBRZDT-UHFFFAOYSA-N
Smile COc1ccc(OC)c(C(O)CNC(=O)CN)c1.Cl
InChI
InChI=1S/C12H18N2O4.ClH/c1-17-8-3-4-11(18-2)9(5-8)10(15)7-14-12(16)6-13;/h3-5,10,15H,6-7,13H2,1-2H3,(H,14,16);1H

Physicochemical Descriptors

Property Name Value
Molecular Formula C12H19ClN2O4
Molecular Weight 290.75
AlogP -0.19
Hydrogen Bond Acceptor 5.0
Hydrogen Bond Donor 3.0
Number of Rotational Bond 6.0
Polar Surface Area 93.81
Molecular species NEUTRAL
Aromatic Rings 1.0
Heavy Atoms 18.0

Pharmacology

Action Mechanism of Action Reference
AGONIST Adrenergic receptor alpha-1 agonist DailyMed
Targets EC50(nM) IC50(nM) Kd(nM) Ki(nM) Inhibition(%)
Transporter Electrochemical transporter SLC superfamily of solute carriers SLC21/SLCO family of organic anion transporting polypeptides
- - - - 102

Indications

Mesh Heading Maximum Phase Mesh ID Reference
Shock, Septic 3 D012772 ClinicalTrials
Stroke 1 D020521 ClinicalTrials
Hypotension, Orthostatic 1 D007024 ClinicalTrials
Sepsis 1 D018805 ClinicalTrials

Related Entries

Parent

Adverse Reactions

SOC By Demographic Distribution
System Organ Classification (SOC)
Relative Frequency (%)
Nervous system disorders
19.88
General disorders and administration site conditions
15.88
Vascular disorders
11.14
Cardiac disorders
8.01
Skin and subcutaneous tissue disorders
6.05
Injury, poisoning and procedural complications
5.9
Gastrointestinal disorders
5.83
Psychiatric disorders
5.68
Investigations
5.03
Musculoskeletal and connective tissue disorders
3.5
Respiratory, thoracic and mediastinal disorders
3.13

Cross References

Resources Reference
ChEBI 31847
ChEMBL CHEMBL1200461
EPA CompTox DTXSID1047493
FDA SRS 59JV96YTXV
PubChem 18340
SureChEMBL SCHEMBL41463
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