MINOXIDIL

Search structure
Trade Names:
Synonyms:
Status: Approved (1979)
Entry Type: Small molecule
Molecule Category: UNKNOWN Prodrug
ATC: C02DC01
UNII: 5965120SH1

Structure
InChI Key ZFMITUMMTDLWHR-UHFFFAOYSA-N
Smile Nc1cc(N2CCCCC2)nc(N)[n+]1[O-]
InChI
InChI=1S/C9H15N5O/c10-7-6-8(12-9(11)14(7)15)13-4-2-1-3-5-13/h6H,1-5,10H2,(H2,11,12)

Physicochemical Descriptors

Property Name Value
Molecular Formula C9H15N5O
Molecular Weight 209.25
AlogP -0.13
Hydrogen Bond Acceptor 5.0
Hydrogen Bond Donor 2.0
Number of Rotational Bond 1.0
Polar Surface Area 95.11
Molecular species NEUTRAL
Aromatic Rings 1.0
Heavy Atoms 15.0

Pharmacology

Action Mechanism of Action Reference
OPENER Sulfonylurea receptor 2, Kir6.2 opener PubMed
Targets EC50(nM) IC50(nM) Kd(nM) Ki(nM) Inhibition(%)
Transporter Electrochemical transporter SLC superfamily of solute carriers SLC21/SLCO family of organic anion transporting polypeptides
- - - - 92

Indications

Mesh Heading Maximum Phase Mesh ID Reference
Alopecia 4 D000505 ClinicalTrials
Alopecia 4 D000505 ClinicalTrials
Hypotrichosis 4 D007039 ClinicalTrials

Adverse Reactions

SOC By Demographic Distribution
System Organ Classification (SOC)
Relative Frequency (%)
Injury, poisoning and procedural complications
33.09
Skin and subcutaneous tissue disorders
32.53
General disorders and administration site conditions
13.12
Product issues
5.22
Nervous system disorders
4.2
Cardiac disorders
2.13

Cross References

Resources Reference
CAS NUMBER 38304-91-5
ChEBI 6942
ChEMBL CHEMBL802
DrugBank DB00350
DrugCentral 1814
EPA CompTox DTXSID9040685
FDA SRS 5965120SH1
Human Metabolome Database HMDB0014494
Guide to Pharmacology 4254
KEGG D00418
PDB MXD
SureChEMBL SCHEMBL29698
ZINC ZINC000000001735
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