NEPAFENAC

Search structure
Trade Names:
Synonyms:
Status: Approved (2005)
Entry Type: Small molecule
Molecule Category: UNKNOWN Prodrug
ATC: S01BC10
UNII: 0J9L7J6V8C

Structure
InChI Key QEFAQIPZVLVERP-UHFFFAOYSA-N
Smile NC(=O)Cc1cccc(C(=O)c2ccccc2)c1N
InChI
InChI=1S/C15H14N2O2/c16-13(18)9-11-7-4-8-12(14(11)17)15(19)10-5-2-1-3-6-10/h1-8H,9,17H2,(H2,16,18)

Physicochemical Descriptors

Property Name Value
Molecular Formula C15H14N2O2
Molecular Weight 254.29
AlogP 1.53
Hydrogen Bond Acceptor 3.0
Hydrogen Bond Donor 2.0
Number of Rotational Bond 4.0
Polar Surface Area 86.18
Molecular species NEUTRAL
Aromatic Rings 2.0
Heavy Atoms 19.0

Pharmacology

Action Mechanism of Action Reference
INHIBITOR Cyclooxygenase inhibitor DailyMed

Indications

Mesh Heading Maximum Phase Mesh ID Reference
Miosis 2 D015877 ClinicalTrials
Macular Edema 2 D008269 ClinicalTrials

Related Entries

Scaffolds

Adverse Reactions

SOC By Demographic Distribution
System Organ Classification (SOC)
Relative Frequency (%)
Eye disorders
37.34
General disorders and administration site conditions
13.8
Nervous system disorders
11.52
Injury, poisoning and procedural complications
9.29
Product issues
6.83
Immune system disorders
4.23
Skin and subcutaneous tissue disorders
3.92
Respiratory, thoracic and mediastinal disorders
2.32
Vascular disorders
2.05

Cross References

Resources Reference
CAS NUMBER 78281-72-8
ChEBI 75922
ChEMBL CHEMBL1021
DrugBank DB06802
DrugCentral 1899
EPA CompTox DTXSID0048638
FDA SRS 0J9L7J6V8C
Human Metabolome Database HMDB0015678
Guide to Pharmacology 7564
PharmGKB PA165958407
PubChem 151075
SureChEMBL SCHEMBL93835
ZINC ZINC000005162311
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