NIVOLUMAB

Search structure
Trade Names:
Synonyms:
Status: Approved (2015)
Entry Type: Antibody
Molecule Category: UNKNOWN
ATC: L01XC17
UNII: 31YO63LBSN

Pharmacology

Action Mechanism of Action Reference
INHIBITOR Programmed cell death protein 1 inhibitor FDA
Primary Target
programmed cell death 1 (CD279)

Indications

Mesh Heading Maximum Phase Mesh ID Reference
Carcinoma, Renal Cell 4 D002292 ClinicalTrials
Melanoma 4 D008545 ClinicalTrials
Hodgkin Disease 4 D006689 ClinicalTrials
Carcinoma, Renal Cell 4 D002292 ClinicalTrials
Carcinoma, Renal Cell 4 D002292 ClinicalTrials
Neoplasms 4 D009369 ClinicalTrials
Carcinoma, Squamous Cell 3 D002294 ClinicalTrials
Esophageal Neoplasms 3 D004938 ClinicalTrials
Lung Neoplasms 3 D008175 ClinicalTrials
Urinary Bladder Neoplasms 3 D001749 ClinicalTrials
Prostatic Neoplasms, Castration-Resistant 3 D064129 ClinicalTrials
Esophageal Neoplasms 3 D004938 ClinicalTrials
Multiple Myeloma 3 D009101 ClinicalTrials
Sarcoma 3 D012509 ClinicalTrials
Carcinoma, Hepatocellular 3 D006528 ClinicalTrials
Carcinoma, Squamous Cell 3 D002294 ClinicalTrials
Urogenital Neoplasms 3 D014565 ClinicalTrials
Carcinoma, Squamous Cell 3 D002294 ClinicalTrials
Breast Neoplasms 3 D001943 ClinicalTrials
Head and Neck Neoplasms 3 D006258 ClinicalTrials
Liver Neoplasms 3 D008113 ClinicalTrials
Stomach Neoplasms 3 D013274 ClinicalTrials
Urinary Bladder Neoplasms 3 D001749 ClinicalTrials
Brain Neoplasms 3 D001932 ClinicalTrials
Head and Neck Neoplasms 3 D006258 ClinicalTrials
Lymphoma, Follicular 3 D008224 ClinicalTrials
Esophageal Neoplasms 3 D004938 ClinicalTrials
Head and Neck Neoplasms 3 D006258 ClinicalTrials
Kidney Neoplasms 3 D007680 ClinicalTrials
Lymphoma, Follicular 3 D008224 ClinicalTrials
Skin Neoplasms 3 D012878 ClinicalTrials
Brain Neoplasms 3 D001932 ClinicalTrials
Breast Neoplasms 3 D001943 ClinicalTrials
Stomach Neoplasms 3 D013274 ClinicalTrials
Sarcoma 3 D012509 ClinicalTrials
Glioblastoma 3 D005909 ClinicalTrials
Urinary Bladder Neoplasms 3 D001749 ClinicalTrials
Adenocarcinoma of Lung 3 D000077192 ClinicalTrials
Mesothelioma 3 D008654 ClinicalTrials
Mesothelioma 3 D008654 ClinicalTrials
Basal Cell Nevus Syndrome 2 D001478 ClinicalTrials
Hemangiosarcoma 2 D006394 ClinicalTrials
Carcinoid Tumor 2 D002276 ClinicalTrials
Pneumonia, Viral 2 D011024 ClinicalTrials
Retroviridae Infections 2 D012192 ClinicalTrials
Peritoneal Neoplasms 2 D010534 ClinicalTrials
Thyroid Neoplasms 2 D013964 ClinicalTrials
Carcinoma, Neuroendocrine 2 D018278 ClinicalTrials
Fallopian Tube Neoplasms 2 D005185 ClinicalTrials
Biliary Tract Neoplasms 2 D001661 ClinicalTrials
Lymphoma 2 D008223 ClinicalTrials
Leukemia, Myeloid, Acute 2 D015470 ClinicalTrials
Small Cell Lung Carcinoma 2 D055752 ClinicalTrials
Pancreatic Neoplasms 2 D010190 ClinicalTrials
Gastrointestinal Stromal Tumors 2 D046152 ClinicalTrials
Glioma 2 D005910 ClinicalTrials
Biliary Tract Neoplasms 2 D001661 ClinicalTrials
Leukemia, Lymphocytic, Chronic, B-Cell 2 D015451 ClinicalTrials
Myelodysplastic Syndromes 2 D009190 ClinicalTrials
Adenocarcinoma 2 D000230 ClinicalTrials
Carcinoma 2 D002277 ClinicalTrials
Lymphoma, Large B-Cell, Diffuse 2 D016403 ClinicalTrials
Sarcoma, Kaposi 2 D012514 ClinicalTrials
Leukemia 2 D007938 ClinicalTrials
Oligodendroglioma 2 D009837 ClinicalTrials
Prostatic Neoplasms 2 D011471 ClinicalTrials
Uterine Cervical Neoplasms 2 D002583 ClinicalTrials
Ovarian Neoplasms 2 D010051 ClinicalTrials
Hematologic Neoplasms 2 D019337 ClinicalTrials
Carcinoma, Pancreatic Ductal 2 D021441 ClinicalTrials
Thyroid Neoplasms 2 D013964 ClinicalTrials
Carcinoma, Large Cell 2 D018287 ClinicalTrials
Colorectal Neoplasms 2 D015179 ClinicalTrials
Nasopharyngeal Neoplasms 2 D009303 ClinicalTrials
Rectal Neoplasms 2 D012004 ClinicalTrials
Adrenal Cortex Neoplasms 2 D000306 ClinicalTrials
Inflammatory Breast Neoplasms 2 D058922 ClinicalTrials
Gliosarcoma 2 D018316 ClinicalTrials
Carcinoma, Merkel Cell 2 D015266 ClinicalTrials
Colonic Neoplasms 2 D003110 ClinicalTrials
Colorectal Neoplasms 2 D015179 ClinicalTrials
Chordoma 2 D002817 ClinicalTrials
Prostatic Neoplasms 2 D011471 ClinicalTrials
Lymphoma, T-Cell, Peripheral 2 D016411 ClinicalTrials
Colorectal Neoplasms 2 D015179 ClinicalTrials
Neoplasms, Germ Cell and Embryonal 2 D009373 ClinicalTrials
Osteosarcoma 2 D012516 ClinicalTrials
Liposarcoma 2 D008080 ClinicalTrials
Carcinoma, Basal Cell 2 D002280 ClinicalTrials
Glioma 2 D005910 ClinicalTrials
Fallopian Tube Neoplasms 2 D005185 ClinicalTrials
Endometrial Neoplasms 2 D016889 ClinicalTrials
Oropharyngeal Neoplasms 2 D009959 ClinicalTrials
Histiocytoma, Malignant Fibrous 2 D051677 ClinicalTrials
Leukoplakia, Oral 2 D007972 ClinicalTrials
Meningioma 2 D008579 ClinicalTrials
Colonic Neoplasms 2 D003110 ClinicalTrials
Carcinoid Tumor 2 D002276 ClinicalTrials
Hematologic Neoplasms 2 D019337 ClinicalTrials
Squamous Cell Carcinoma of Head and Neck 2 D000077195 ClinicalTrials
Leiomyosarcoma 2 D007890 ClinicalTrials
Hepatitis B, Chronic 2 D019694 ClinicalTrials
Hepatitis B, Chronic 2 D019694 ClinicalTrials
Cholangiocarcinoma 2 D018281 ClinicalTrials
Carcinoma, Small Cell 2 D018288 ClinicalTrials
Pulmonary Disease, Chronic Obstructive 2 D029424 ClinicalTrials
Squamous Cell Carcinoma of Head and Neck 2 D000077195 ClinicalTrials
Severe Acute Respiratory Syndrome 2 D045169 ClinicalTrials
Glioma 2 D005910 ClinicalTrials
Meningioma 2 D008579 ClinicalTrials
Lymphoma, Large-Cell, Anaplastic 2 D017728 ClinicalTrials
Uterine Cervical Neoplasms 2 D002583 ClinicalTrials
Lymphoma, Non-Hodgkin 2 D008228 ClinicalTrials
Salivary Gland Neoplasms 2 D012468 ClinicalTrials
Ovarian Neoplasms 2 D010051 ClinicalTrials
Pituitary Neoplasms 2 D010911 ClinicalTrials
Precursor Cell Lymphoblastic Leukemia-Lymphoma 1 D054198 ClinicalTrials
Nerve Sheath Neoplasms 1 D018317 ClinicalTrials
Triple Negative Breast Neoplasms 1 D064726 ClinicalTrials
Hepatitis D 1 D003699 ClinicalTrials
Diffuse Intrinsic Pontine Glioma 1 D000080443 ClinicalTrials
Mycosis Fungoides 1 D009182 ClinicalTrials
Neuroblastoma 1 D009447 ClinicalTrials
Neoplasm Metastasis 1 D009362 ClinicalTrials
Retroperitoneal Neoplasms 1 D012186 ClinicalTrials
Sepsis 1 D018805 ClinicalTrials
Lymphoma, T-Cell 1 D016399 ClinicalTrials
Leukemia, Myelogenous, Chronic, BCR-ABL Positive 1 D015464 ClinicalTrials
Lymphoma, Mantle-Cell 1 D020522 ClinicalTrials
Genital Neoplasms, Female 1 D005833 ClinicalTrials
Sezary Syndrome 1 D012751 ClinicalTrials
Precursor Cell Lymphoblastic Leukemia-Lymphoma 1 D054198 ClinicalTrials

Adverse Reactions

SOC By Demographic Distribution
System Organ Classification (SOC)
Relative Frequency (%)
General disorders and administration site conditions
11.84
Respiratory, thoracic and mediastinal disorders
8.4
Gastrointestinal disorders
8.33
Metabolism and nutrition disorders
6.25
Nervous system disorders
6.0
Neoplasms benign, malignant and unspecified (incl cysts and polyps)
5.93
Investigations
5.7
Skin and subcutaneous tissue disorders
5.21
Injury, poisoning and procedural complications
5.07
Infections and infestations
4.48
Cardiac disorders
4.35
Immune system disorders
4.2
Vascular disorders
4.18
Endocrine disorders
4.11
Musculoskeletal and connective tissue disorders
4.07
Hepatobiliary disorders
2.53
Blood and lymphatic system disorders
2.49
Renal and urinary disorders
2.21

Cross References

Resources Reference
CAS NUMBER 946414-94-4
ChEMBL CHEMBL2108738
FDA SRS 31YO63LBSN
Guide to Pharmacology 7335
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