Pharmacology

Action Mechanism of Action Reference
BINDING AGENT B-lymphocyte antigen CD20 binding agent FDA PubMed
Primary Target
CD20 (membrane-spanning 4-domains, subfamily A, member 1)

Indications

Mesh Heading Maximum Phase Mesh ID Reference
Lymphoma, Follicular 4 D008224 ClinicalTrials
Neoplasms 4 D009369 ClinicalTrials
Lupus Erythematosus, Systemic 3 D008180 ClinicalTrials
Kidney Diseases 3 D007674 ClinicalTrials
Lupus Nephritis 3 D008181 ClinicalTrials
Lymphoma, Non-Hodgkin 3 D008228 ClinicalTrials
Lymphoma, Large B-Cell, Diffuse 3 D016403 ClinicalTrials
Carcinoma, Non-Small-Cell Lung 2 D002289 ClinicalTrials
Lymphoma 2 D008223 ClinicalTrials
Lymphoma, Mantle-Cell 2 D020522 ClinicalTrials
Waldenstrom Macroglobulinemia 2 D008258 ClinicalTrials
Leukemia, Hairy Cell 2 D007943 ClinicalTrials
Graft vs Host Disease 2 D006086 ClinicalTrials
Precursor Cell Lymphoblastic Leukemia-Lymphoma 2 D054198 ClinicalTrials
Leukemia, Prolymphocytic 1 D015463 ClinicalTrials
Leukemia 1 D007938 ClinicalTrials
Renal Insufficiency, Chronic 1 D051436 ClinicalTrials
Hodgkin Disease 1 D006689 ClinicalTrials
Burkitt Lymphoma 1 D002051 ClinicalTrials
Mycosis Fungoides 1 D009182 ClinicalTrials
Colorectal Neoplasms 1 D015179 ClinicalTrials

Adverse Reactions

System Organ Classification (SOC)
Relative Frequency (%)
General disorders and administration site conditions
13.61
Blood and lymphatic system disorders
10.67
Respiratory, thoracic and mediastinal disorders
9.7
Infections and infestations
7.97
Investigations
6.74
Cardiac disorders
6.66
Vascular disorders
6.02
Nervous system disorders
4.99
Neoplasms benign, malignant and unspecified (incl cysts and polyps)
4.74
Gastrointestinal disorders
4.5
Injury, poisoning and procedural complications
4.27
Metabolism and nutrition disorders
3.56
Immune system disorders
3.5
Skin and subcutaneous tissue disorders
3.11
Renal and urinary disorders
2.76
Musculoskeletal and connective tissue disorders
2.26

Cross References

Resources Reference
CAS NUMBER 949142-50-1
ChEMBL CHEMBL1743048
FDA SRS O43472U9X8
Guide to Pharmacology 6941