Trade Names:
Synonyms:
Status: Approved (2016)
Entry Type: Antibody
Molecule Category: UNKNOWN
ATC: L01XC27
UNII: TT6HN20MVF

Pharmacology

Action Mechanism of Action Reference
ANTAGONIST Platelet-derived growth factor receptor alpha antagonist PubMed PubMed
Primary Target
platelet derived growth factor receptor alpha

Indications

Mesh Heading Maximum Phase Mesh ID Reference
Sarcoma 4 D012509 ClinicalTrials
Neoplasms 4 D009369 ClinicalTrials
Sarcoma 4 D012509 FDA
Carcinoma, Non-Small-Cell Lung 2 D002289 ClinicalTrials
Ovarian Neoplasms 2 D010051 ClinicalTrials
Prostatic Neoplasms, Castration-Resistant 2 D064129 ClinicalTrials
Gastrointestinal Stromal Tumors 2 D046152 ClinicalTrials
Glioblastoma 2 D005909 ClinicalTrials
Pancreatic Neoplasms 1 D010190 ClinicalTrials
Neoplasm Metastasis 1 D009362 ClinicalTrials
Leiomyosarcoma 1 D007890 ClinicalTrials

Adverse Reactions

System Organ Classification (SOC)
Relative Frequency (%)
General disorders and administration site conditions
15.46
Injury, poisoning and procedural complications
12.48
Vascular disorders
9.97
Immune system disorders
8.79
Respiratory, thoracic and mediastinal disorders
7.61
Cardiac disorders
7.54
Nervous system disorders
6.59
Blood and lymphatic system disorders
6.2
Investigations
6.04
Gastrointestinal disorders
5.26
Skin and subcutaneous tissue disorders
3.92
Neoplasms benign, malignant and unspecified (incl cysts and polyps)
2.04

Cross References

Resources Reference
CAS NUMBER 1024603-93-7
ChEMBL CHEMBL1743049
FDA SRS TT6HN20MVF
Guide to Pharmacology 9172