OLODATEROL HYDROCHLORIDE

Search structure
Trade Names:
Synonyms:
Status: Approved (2014)
Entry Type: Small molecule
Molecule Category: Salt
UNII: 65R445W3V9
Parent Compound: OLODATEROL

Structure
InChI Key KCEHVJZZIGJAAW-FERBBOLQSA-N
Smile COc1ccc(CC(C)(C)NC[C@H](O)c2cc(O)cc3c2OCC(=O)N3)cc1.Cl
InChI
InChI=1S/C21H26N2O5.ClH/c1-21(2,10-13-4-6-15(27-3)7-5-13)22-11-18(25)16-8-14(24)9-17-20(16)28-12-19(26)23-17;/h4-9,18,22,24-25H,10-12H2,1-3H3,(H,23,26);1H/t18-;/m0./s1

Physicochemical Descriptors

Property Name Value
Molecular Formula C21H27ClN2O5
Molecular Weight 422.91
AlogP 2.38
Hydrogen Bond Acceptor 6.0
Hydrogen Bond Donor 4.0
Number of Rotational Bond 7.0
Polar Surface Area 100.05
Molecular species BASE
Aromatic Rings 2.0
Heavy Atoms 28.0

Pharmacology

Action Mechanism of Action Reference
AGONIST Beta-2 adrenergic receptor agonist FDA
Targets EC50(nM) IC50(nM) Kd(nM) Ki(nM) Inhibition(%)
Membrane receptor Family A G protein-coupled receptor Small molecule receptor (family A GPCR) Monoamine receptor Adrenergic receptor
0 - - - -

Indications

Mesh Heading Maximum Phase Mesh ID Reference

Related Entries

Scaffolds

Parent
Mixture

Adverse Reactions

SOC By Demographic Distribution
System Organ Classification (SOC)
Relative Frequency (%)
Respiratory, thoracic and mediastinal disorders
24.26
General disorders and administration site conditions
12.57
Cardiac disorders
12.04
Injury, poisoning and procedural complications
7.85
Nervous system disorders
7.33
Gastrointestinal disorders
5.06
Infections and infestations
4.36
Psychiatric disorders
4.36
Vascular disorders
4.36
Musculoskeletal and connective tissue disorders
3.49
Investigations
2.79
Skin and subcutaneous tissue disorders
2.44

Cross References

Resources Reference
ChEBI 83309
ChEMBL CHEMBL2105743
FDA SRS 65R445W3V9
PubChem 11711522
SureChEMBL SCHEMBL560669
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