ONDANSETRON HYDROCHLORIDE

Search structure
Trade Names:
Synonyms:
Status: Approved (1991)
Entry Type: Small molecule
Molecule Category: Salt
UNII: NMH84OZK2B
Parent Compound: ONDANSETRON

Structure
InChI Key MKBLHFILKIKSQM-UHFFFAOYSA-N
Smile Cc1nccn1CC1CCc2c(c3ccccc3n2C)C1=O.Cl
InChI
InChI=1S/C18H19N3O.ClH/c1-12-19-9-10-21(12)11-13-7-8-16-17(18(13)22)14-5-3-4-6-15(14)20(16)2;/h3-6,9-10,13H,7-8,11H2,1-2H3;1H

Physicochemical Descriptors

Property Name Value
Molecular Formula C18H24ClN3O3
Molecular Weight 365.86
AlogP 3.13
Hydrogen Bond Acceptor 4.0
Hydrogen Bond Donor 0.0
Number of Rotational Bond 2.0
Polar Surface Area 39.82
Molecular species NEUTRAL
Aromatic Rings 3.0
Heavy Atoms 22.0

Pharmacology

Action Mechanism of Action Reference
ANTAGONIST Serotonin 3a (5-HT3a) receptor antagonist DailyMed

Indications

Mesh Heading Maximum Phase Mesh ID Reference
Nausea 4 D009325 ClinicalTrials
Nausea 4 D009325 ClinicalTrials
Pain 3 D010146 ClinicalTrials
Mycobacterium avium-intracellulare Infection 2 D015270 ClinicalTrials
Lecithin Cholesterol Acyltransferase Deficiency 1 D007863 ClinicalTrials
Brain Concussion 0 D001924 ClinicalTrials

Related Entries

Scaffolds

Parent

Adverse Reactions

SOC By Demographic Distribution
System Organ Classification (SOC)
Relative Frequency (%)
Injury, poisoning and procedural complications
10.58
Cardiac disorders
10.02
Congenital, familial and genetic disorders
8.94
Respiratory, thoracic and mediastinal disorders
8.19
Psychiatric disorders
7.89
Pregnancy, puerperium and perinatal conditions
7.54
General disorders and administration site conditions
6.59
Gastrointestinal disorders
6.04
Nervous system disorders
5.07
Infections and infestations
4.84
Vascular disorders
3.83
Musculoskeletal and connective tissue disorders
2.99
Skin and subcutaneous tissue disorders
2.96
Metabolism and nutrition disorders
2.39

Cross References

Resources Reference
ChEBI 7774
ChEMBL CHEMBL3186492
EPA CompTox DTXSID9048857
FDA SRS NMH84OZK2B
PubChem 59774
SureChEMBL SCHEMBL25018
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