OXICONAZOLE NITRATE

Search structure
Trade Names:
Synonyms:
Status: Approved (1988)
Entry Type: Small molecule
Molecule Category: UNKNOWN
UNII: RQ8UL4C17S

Structure
InChI Key WVNOAGNOIPTWPT-NDUABGMUSA-N
Smile Clc1ccc(CO/N=C(\Cn2ccnc2)c2ccc(Cl)cc2Cl)c(Cl)c1.O=[N+]([O-])O
InChI
InChI=1S/C18H13Cl4N3O.HNO3/c19-13-2-1-12(16(21)7-13)10-26-24-18(9-25-6-5-23-11-25)15-4-3-14(20)8-17(15)22;2-1(3)4/h1-8,11H,9-10H2;(H,2,3,4)/b24-18+;

Physicochemical Descriptors

Property Name Value
Molecular Formula C18H14Cl4N4O4
Molecular Weight 492.15
AlogP 6.12
Hydrogen Bond Acceptor 4.0
Hydrogen Bond Donor 0.0
Number of Rotational Bond 6.0
Polar Surface Area 39.41
Molecular species NEUTRAL
Aromatic Rings 3.0
Heavy Atoms 26.0

Pharmacology

Action Mechanism of Action Reference
INHIBITOR Cytochrome P450 51 inhibitor PubMed PubMed
Targets EC50(nM) IC50(nM) Kd(nM) Ki(nM) Inhibition(%)
Transporter Electrochemical transporter SLC superfamily of solute carriers SLC21/SLCO family of organic anion transporting polypeptides
- - - - 116
Transporter Primary active transporter ATP-binding cassette ABCB subfamily
- 49300 - - -

Indications

Mesh Heading Maximum Phase Mesh ID Reference

Related Entries

Scaffolds

Adverse Reactions

SOC By Demographic Distribution
System Organ Classification (SOC)
Relative Frequency (%)
Skin and subcutaneous tissue disorders
38.07
General disorders and administration site conditions
20.45
Injury, poisoning and procedural complications
10.23
Nervous system disorders
7.39
Infections and infestations
6.82
Immune system disorders
3.98
Psychiatric disorders
3.41
Musculoskeletal and connective tissue disorders
2.84
Cardiac disorders
2.27

Cross References

Resources Reference
ChEBI 7826
ChEMBL CHEMBL1200836
EPA CompTox DTXSID2045943
FDA SRS RQ8UL4C17S
KEGG C08075
PubChem 9556529
SureChEMBL SCHEMBL153416
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