PAROXETINE HYDROCHLORIDE

Search structure
Trade Names:
Synonyms:
Status: Approved (1992)
Entry Type: Small molecule
Molecule Category: Salt
UNII: 3I3T11UD2S
Parent Compound: PAROXETINE

Structure
InChI Key GELRVIPPMNMYGS-RVXRQPKJSA-N
Smile Cl.Fc1ccc([C@@H]2CCNC[C@H]2COc2ccc3c(c2)OCO3)cc1
InChI
InChI=1S/C19H20FNO3.ClH/c20-15-3-1-13(2-4-15)17-7-8-21-10-14(17)11-22-16-5-6-18-19(9-16)24-12-23-18;/h1-6,9,14,17,21H,7-8,10-12H2;1H/t14-,17-;/m0./s1

Physicochemical Descriptors

Property Name Value
Molecular Formula C19H21ClFNO3
Molecular Weight 365.83
AlogP 3.33
Hydrogen Bond Acceptor 4.0
Hydrogen Bond Donor 1.0
Number of Rotational Bond 4.0
Polar Surface Area 39.72
Molecular species BASE
Aromatic Rings 2.0
Heavy Atoms 24.0

Pharmacology

Action Mechanism of Action Reference
INHIBITOR Serotonin transporter inhibitor DailyMed
Targets EC50(nM) IC50(nM) Kd(nM) Ki(nM) Inhibition(%)
Enzyme Cytochrome P450 Cytochrome P450 family 1 Cytochrome P450 family 1A Cytochrome P450 1A2
- 5330 - - -
Enzyme Cytochrome P450 Cytochrome P450 family 2 Cytochrome P450 family 2D Cytochrome P450 2D6
- 960 - - -
Enzyme Cytochrome P450 Cytochrome P450 family 3 Cytochrome P450 family 3A Cytochrome P450 3A4
- 24100 - - -
Enzyme Kinase Protein Kinase AGC protein kinase group AGC protein kinase GRK family AGC protein kinase BARK subfamily
- 2500-19900 - - -
Transporter Electrochemical transporter SLC superfamily of solute carriers SLC06 neurotransmitter transporter family
- - - 0 -
Transporter Electrochemical transporter SLC superfamily of solute carriers SLC21/SLCO family of organic anion transporting polypeptides
- - - - 76
Transporter Primary active transporter ATP-binding cassette ABCB subfamily
- 68910 - - -

Metabolites

visNetwork

Indications

Mesh Heading Maximum Phase Mesh ID Reference
Anxiety 1 D001007 ClinicalTrials
Depressive Disorder 1 D003866 ClinicalTrials

Related Entries

Scaffolds

Parent

Side Effects from Label

Side effects Relative Frequency (%) Labels
Gastrointestinal disorders Nausea 36.3
Gastrointestinal disorders Nausea 34.7
Reproductive system and breast disorders Ejaculation disorder 27.0
Nervous system disorders Headache 27.0
Gastrointestinal disorders Nausea 26.9
Reproductive system and breast disorders Ejaculation disorder 26.0
Nervous system disorders Headache 23.0
Gastrointestinal disorders Nausea 23.0
Gastrointestinal disorders Nausea 22.0
Nervous system disorders Somnolence 22.0
Nervous system disorders Somnolence 21.6
Nervous system disorders Somnolence 21.0
Nervous system disorders Somnolence 20.8
Gastrointestinal disorders Dry mouth 20.6
Nervous system disorders Headache
Nervous system disorders Insomnia 20.0
Nervous system disorders Somnolence 20.0
Gastrointestinal disorders Diarrhoea 19.2
Gastrointestinal disorders Dry mouth 18.3
Nervous system disorders Somnolence 18.3
General disorders and administration site conditions Asthenia 18.0
Gastrointestinal disorders Diarrhoea 18.0
Gastrointestinal disorders Dry mouth 18.0
Gastrointestinal disorders Nausea 18.0
General disorders and administration site conditions Asthenia 17.0
Reproductive system and breast disorders Ejaculation disorder 17.0
Nervous system disorders Headache
Nervous system disorders Headache 17.0
Nervous system disorders Insomnia 17.0
Gastrointestinal disorders Nausea
Gastrointestinal disorders Nausea 17.0
Gastrointestinal disorders Dry mouth 15.8
General disorders and administration site conditions Asthenia 15.0
Gastrointestinal disorders Diarrhoea 15.0
Gastrointestinal disorders Dry mouth 15.0
Reproductive system and breast disorders Ejaculation disorder 15.0
Nervous system disorders Headache 15.0
Nervous system disorders Somnolence 15.0
Gastrointestinal disorders Diarrhoea 14.7
Gastrointestinal disorders Nausea 14.7
Nervous system disorders Tremor 14.7
General disorders and administration site conditions Asthenia
General disorders and administration site conditions Asthenia 14.0
Cardiac disorders Dizziness 14.0
Nervous system disorders Headache 14.0
General disorders and administration site conditions Hyperhidrosis 14.0
General disorders and administration site conditions Asthenia 13.9
Gastrointestinal disorders Nausea
Gastrointestinal disorders Nausea 13.7
Gastrointestinal disorders Constipation 13.0
Psychiatric disorders Disturbance in sexual arousal 13.0
Gastrointestinal disorders Dry mouth 13.0
Gastrointestinal disorders Dyspepsia 13.0
Reproductive system and breast disorders Ejaculation disorder 13.0
Nervous system disorders Headache
Psychiatric disorders Libido decreased 13.0
General disorders and administration site conditions Asthenia 12.7
Gastrointestinal disorders Constipation 12.7
Cardiac disorders Dizziness 12.7
Nervous system disorders Somnolence 12.7
General disorders and administration site conditions Decreased appetite 12.0
Gastrointestinal disorders Diarrhoea 12.0
Psychiatric disorders Disturbance in sexual arousal 12.0
Nervous system disorders Headache
Psychiatric disorders Libido decreased 12.0
Nervous system disorders Somnolence
General disorders and administration site conditions Hyperhidrosis 11.8
Gastrointestinal disorders Dry mouth 11.0
Nervous system disorders Insomnia
Gastrointestinal disorders Dry mouth 10.8
General disorders and administration site conditions Asthenia 10.6
Reproductive system and breast disorders Ejaculation disorder 10.6
General disorders and administration site conditions Asthenia
Gastrointestinal disorders Constipation 10.0
Psychiatric disorders Disturbance in sexual arousal 10.0
Gastrointestinal disorders Dyspepsia
Psychiatric disorders Erectile dysfunction 10.0
General disorders and administration site conditions Hyperhidrosis 10.0
Nervous system disorders Insomnia 10.0
Psychiatric disorders Libido decreased 10.0
Gastrointestinal disorders Nausea
Reproductive system and breast disorders Reproductive tract disorder 10.0
Gastrointestinal disorders Constipation 9.9
Gastrointestinal disorders Diarrhoea 9.8
General disorders and administration site conditions Asthenia
Gastrointestinal disorders Constipation 9.0
Gastrointestinal disorders Diarrhoea
Gastrointestinal disorders Diarrhoea 9.0
Psychiatric disorders Disturbance in sexual arousal 9.0
Cardiac disorders Dizziness 9.0
Gastrointestinal disorders Dry mouth
Psychiatric disorders Erectile dysfunction 9.0
Nervous system disorders Insomnia
Nervous system disorders Insomnia 9.0
Psychiatric disorders Libido decreased 9.0
Nervous system disorders Somnolence
Nervous system disorders Somnolence 9.0
Cardiac disorders Dizziness 8.9
General disorders and administration site conditions Hyperhidrosis 8.9
Genital disorder male 8.7
General disorders and administration site conditions Decreased appetite 8.0
Gastrointestinal disorders Diarrhoea
Psychiatric disorders Disturbance in sexual arousal 8.0
Gastrointestinal disorders Dry mouth
Gastrointestinal disorders Flatulence 8.0
Genital disorder female 8.0
Infections and infestations Infection 8.0
Injury, poisoning and procedural complications Injury 8.0
Nervous system disorders Insomnia
Nervous system disorders Insomnia 8.0
Psychiatric disorders Libido decreased 8.0
Psychiatric disorders Nervousness 8.0
Infections and infestations Sinusitis 8.0
Nervous system disorders Somnolence
Psychiatric disorders Tension 8.0
Nervous system disorders Tremor 8.0
Gastrointestinal disorders Diarrhoea 7.9
Nervous system disorders Tremor 7.9
Gastrointestinal disorders Diarrhoea
Gastrointestinal disorders Diarrhoea 7.8
Nervous system disorders Somnolence
Nervous system disorders Somnolence 7.8
Eye disorders Vision blurred 7.8
Gastrointestinal disorders Constipation 7.7
Nervous system disorders Tremor 7.7
Gastrointestinal disorders Abdominal pain 7.0
General disorders and administration site conditions Asthenia
Gastrointestinal disorders Diarrhoea
Gastrointestinal disorders Diarrhoea 7.0
Psychiatric disorders Disturbance in sexual arousal 7.0
Cardiac disorders Dizziness 7.0
Gastrointestinal disorders Dry mouth
Gastrointestinal disorders Flatulence
Gastrointestinal disorders Gastrointestinal pain 7.0
Genital disorder female 7.0
General disorders and administration site conditions Hyperhidrosis 7.0
Nervous system disorders Insomnia 7.0
Psychiatric disorders Libido decreased 7.0
Gastrointestinal disorders Nausea
Psychiatric disorders Nervousness
Psychiatric disorders Tension
Nervous system disorders Tremor 7.0
Cardiac disorders Dizziness 6.9
Cardiac disorders Dizziness 6.7
General disorders and administration site conditions Hyperhidrosis 6.7
Reproductive system and breast disorders Ejaculation disorder 6.5
Psychiatric disorders Erectile dysfunction 6.4
Genital disorder male 6.4
Nervous system disorders Headache 6.3
Gastrointestinal disorders Abdominal pain 6.0
General disorders and administration site conditions Asthenia
Gastrointestinal disorders Constipation
General disorders and administration site conditions Decreased appetite
Gastrointestinal disorders Diarrhoea 6.0
Psychiatric disorders Disturbance in sexual arousal
Cardiac disorders Dizziness 6.0
Gastrointestinal disorders Flatulence 6.0
Gastrointestinal disorders Gastrointestinal pain 6.0
General disorders and administration site conditions Hyperhidrosis 6.0
Infections and infestations Infection 6.0
Psychiatric disorders Libido decreased
Gastrointestinal disorders Nausea
Gastrointestinal disorders Nausea 6.0
Nervous system disorders Tremor 6.0
Psychiatric disorders Anxiety 5.9
Gastrointestinal disorders Constipation
Gastrointestinal disorders Constipation 5.9
Psychiatric disorders Nervousness 5.9
Nervous system disorders Paraesthesia 5.9
Psychiatric disorders Tension 5.9
Psychiatric disorders Anxiety 5.8
General disorders and administration site conditions Decreased appetite 5.8
Reproductive system and breast disorders Ejaculation disorder 5.8
Psychiatric disorders Nervousness 5.8
Psychiatric disorders Tension 5.8
Gastrointestinal disorders Abdominal pain 5.0
Psychiatric disorders Anxiety 5.0
Musculoskeletal and connective tissue disorders Back pain 5.0
Gastrointestinal disorders Constipation
Gastrointestinal disorders Constipation 5.0
General disorders and administration site conditions Decreased appetite
General disorders and administration site conditions Decreased appetite 5.0
Psychiatric disorders Disturbance in sexual arousal
Cardiac disorders Dizziness
Cardiac disorders Dizziness 5.0
Gastrointestinal disorders Dry mouth 5.0
Psychiatric disorders Erectile dysfunction 5.0
Gastrointestinal disorders Gastrointestinal pain 5.0
Infections and infestations Infection
Injury, poisoning and procedural complications Injury
Injury, poisoning and procedural complications Injury 5.0
Psychiatric disorders Libido decreased
Musculoskeletal and connective tissue disorders Musculoskeletal discomfort 5.0
Musculoskeletal and connective tissue disorders Myalgia 5.0
Nervous system disorders Paraesthesia 5.0
Infections and infestations Sinusitis
Nervous system disorders Somnolence 5.0
Nervous system disorders Tremor 5.0
Eye disorders Visual impairment 5.0
Respiratory, thoracic and mediastinal disorders Yawning 5.0
General disorders and administration site conditions Asthenia 4.9
Gastrointestinal disorders Constipation 4.9
General disorders and administration site conditions Decreased appetite 4.9
Reproductive system and breast disorders Ejaculation disorder 4.9
General disorders and administration site conditions Asthenia 4.88
General disorders and administration site conditions Discomfort 4.88
General disorders and administration site conditions Fatigue 4.88
General disorders and administration site conditions Feeling abnormal 4.88
General disorders and administration site conditions Ill-defined disorder 4.88
General disorders and administration site conditions Lethargy 4.88
General disorders and administration site conditions Malaise 4.88
Nervous system disorders Headache
Nervous system disorders Disturbance in attention 4.3
Psychiatric disorders Erectile dysfunction 4.3
Social circumstances Mental disability 4.3
Nervous system disorders Somnolence 4.3
Gastrointestinal disorders Nausea 4.25
Gastrointestinal disorders Vomiting 4.25
General disorders and administration site conditions Hyperhidrosis 4.2
Gastrointestinal disorders Abdominal pain
Psychiatric disorders Anxiety
General disorders and administration site conditions Asthenia
Musculoskeletal and connective tissue disorders Back pain 4.0
Gastrointestinal disorders Constipation
General disorders and administration site conditions Decreased appetite 4.0
Psychiatric disorders Disturbance in sexual arousal
Psychiatric disorders Disturbance in sexual arousal 4.0
Cardiac disorders Dizziness
Gastrointestinal disorders Dry mouth 4.0
Gastrointestinal disorders Flatulence
Gastrointestinal disorders Gastrointestinal pain
Infections and infestations Infection
Injury, poisoning and procedural complications Injury
Nervous system disorders Insomnia
Psychiatric disorders Libido decreased
Psychiatric disorders Libido decreased 4.0
Gastrointestinal disorders Nausea 4.0
Psychiatric disorders Nervousness 4.0
Infections and infestations Rhinitis 4.0
Infections and infestations Sinusitis 4.0
Nervous system disorders Somnolence
Psychiatric disorders Tension 4.0
Nervous system disorders Tremor 4.0
Respiratory, thoracic and mediastinal disorders Yawning 4.0
Cardiac disorders Dizziness
Cardiac disorders Dizziness 3.9
Genital disorder male 3.8
Genital disorder male 3.7
Gastrointestinal disorders Nausea 3.7
Gastrointestinal disorders Nausea 3.4
Nervous system disorders Somnolence 3.4
Gastrointestinal disorders Constipation 3.2
Gastrointestinal disorders Diarrhoea 3.2
Gastrointestinal disorders Dry mouth 3.2
Gastrointestinal disorders Flatulence 3.2
Gastrointestinal disorders Nausea 3.2
Gastrointestinal disorders Vomiting 3.2
Respiratory, thoracic and mediastinal disorders Yawning 3.2
Nervous system disorders Insomnia 3.1
Gastrointestinal disorders Abdominal pain 3.0
Nervous system disorders Agitation 3.0
General disorders and administration site conditions Asthenia 3.0
Musculoskeletal and connective tissue disorders Back pain
Nervous system disorders Disturbance in attention 3.0
Psychiatric disorders Disturbance in sexual arousal
Cardiac disorders Dizziness
Gastrointestinal disorders Dry mouth 3.0
Reproductive system and breast disorders Ejaculation disorder
Psychiatric disorders Erectile dysfunction
Gastrointestinal disorders Gastrointestinal pain 3.0
Genital disorder female 3.0
General disorders and administration site conditions Hyperhidrosis
Musculoskeletal and connective tissue disorders Hypertonia 3.0
General disorders and administration site conditions Increased appetite 3.0
Infections and infestations Infection 3.0
Injury, poisoning and procedural complications Injury 3.0
Nervous system disorders Insomnia
Psychiatric disorders Libido decreased
Social circumstances Mental disability 3.0
Musculoskeletal and connective tissue disorders Musculoskeletal discomfort
Musculoskeletal and connective tissue disorders Myalgia
Psychiatric disorders Nervousness 3.0
General disorders and administration site conditions Pain 3.0
Nervous system disorders Paraesthesia 3.0
Infections and infestations Sinusitis 3.0
Nervous system disorders Somnolence 3.0
Psychiatric disorders Tension 3.0
Infections and infestations Urinary tract infection 3.0
Surgical and medical procedures Vasodilation procedure 3.0
Eye disorders Visual impairment 3.0
Gastrointestinal disorders Vomiting 3.0
Investigations Weight increased 3.0
Respiratory, thoracic and mediastinal disorders Yawning 3.0
General disorders and administration site conditions Asthenia 2.9
Gastrointestinal disorders Nausea 2.9
Psychiatric disorders Nervousness 2.9
Nervous system disorders Paraesthesia 2.9
Psychiatric disorders Tension 2.9
Eye disorders Vision blurred 2.9
General disorders and administration site conditions Asthenia
General disorders and administration site conditions Discomfort
General disorders and administration site conditions Fatigue
General disorders and administration site conditions Feeling abnormal
General disorders and administration site conditions Ill-defined disorder
General disorders and administration site conditions Lethargy
General disorders and administration site conditions Malaise
Nervous system disorders Somnolence 2.8
Cardiac disorders Dizziness 2.6
General disorders and administration site conditions Asthenia 2.5
Reproductive system and breast disorders Ejaculation disorder 2.5
Gastrointestinal disorders Nausea 2.4
Gastrointestinal disorders Nausea
Gastrointestinal disorders Vomiting
Nervous system disorders Insomnia 2.3
Gastrointestinal disorders Nausea 2.3
Nervous system disorders Somnolence 2.3
Gastrointestinal disorders Nausea 2.2
Reproductive system and breast disorders Ejaculation disorder 2.1
Eye disorders Accommodation disorder 2.0
Nervous system disorders Agitation
Nervous system disorders Agitation 2.0
Psychiatric disorders Anxiety 2.0
Musculoskeletal and connective tissue disorders Arthralgia 2.0
Infections and infestations Bronchitis 2.0
Gastrointestinal disorders Constipation
Gastrointestinal disorders Constipation 2.0
Respiratory, thoracic and mediastinal disorders Cough 2.0
General disorders and administration site conditions Decreased appetite
General disorders and administration site conditions Decreased appetite 2.0
Psychiatric disorders Depression 2.0
Gastrointestinal disorders Diarrhoea
Gastrointestinal disorders Diarrhoea 2.0
Nervous system disorders Disturbance in attention 2.0
Psychiatric disorders Disturbance in sexual arousal
Psychiatric disorders Disturbance in sexual arousal 2.0
Gastrointestinal disorders Dry mouth
Gastrointestinal disorders Dry mouth 2.0
Gastrointestinal disorders Dysgeusia 2.0
Gastrointestinal disorders Dyspepsia
Gastrointestinal disorders Dyspepsia 2.0
Renal and urinary disorders Dysuria 2.0
Gastrointestinal disorders Flatulence 2.0
Genital disorder female 2.0
General disorders and administration site conditions Hyperhidrosis
General disorders and administration site conditions Hyperhidrosis 2.0
Immune system disorders Hypersensitivity 2.0
Vascular disorders Hypertension 2.0
Musculoskeletal and connective tissue disorders Hypertonia 2.0
Infections and infestations Infection
Nervous system disorders Insomnia
Psychiatric disorders Libido decreased
Psychiatric disorders Libido decreased 2.0
Reproductive system and breast disorders Menstrual disorder 2.0
Social circumstances Mental disability 2.0
Nervous system disorders Migraine 2.0
Musculoskeletal and connective tissue disorders Musculoskeletal discomfort 2.0
Nervous system disorders Myoclonus 2.0
Gastrointestinal disorders Nausea
Gastrointestinal disorders Nausea 2.0
Psychiatric disorders Nervousness
Psychiatric disorders Nervousness 2.0
Skin and subcutaneous tissue disorders Photosensitivity reaction 2.0
Renal and urinary disorders Pollakiuria 2.0
Infections and infestations Sinusitis
Nervous system disorders Somnolence
Nervous system disorders Somnolence 2.0
Cardiac disorders Tachycardia 2.0
Psychiatric disorders Tension
Psychiatric disorders Tension 2.0
Nervous system disorders Tremor
Infections and infestations Vaginal infection 2.0
Vaginal inflammation 2.0
Surgical and medical procedures Vasodilation procedure
Ear and labyrinth disorders Vertigo 2.0
Eye disorders Vision blurred
Eye disorders Vision blurred 2.0
Eye disorders Visual impairment 2.0
Gastrointestinal disorders Vomiting 2.0
Respiratory, thoracic and mediastinal disorders Yawning 2.0
General disorders and administration site conditions Asthenia 1.9
Psychiatric disorders Depression 1.9
Cardiac disorders Dizziness 1.9
Psychiatric disorders Erectile dysfunction 1.9
Nervous system disorders Headache 1.9
Gastrointestinal disorders Nausea 1.9
Nervous system disorders Somnolence 1.9
General disorders and administration site conditions Asthenia 1.8
Nervous system disorders Insomnia 1.8
Nervous system disorders Somnolence 1.8
Cardiac disorders Dizziness 1.7
Nervous system disorders Insomnia 1.7
Nervous system disorders Tremor 1.7
General disorders and administration site conditions Asthenia 1.6
Reproductive system and breast disorders Ejaculation disorder 1.6
Nervous system disorders Headache 1.6
General disorders and administration site conditions Asthenia 1.5
Nervous system disorders Disturbance in attention 1.5
Cardiac disorders Dizziness 1.5
Psychiatric disorders Erectile dysfunction 1.5
Nervous system disorders Insomnia 1.5
Social circumstances Mental disability 1.5
Nervous system disorders Tremor 1.5
General disorders and administration site conditions Asthenia
General disorders and administration site conditions Decreased appetite 1.4
Cardiac disorders Dizziness 1.4
Nervous system disorders Headache 1.4
General disorders and administration site conditions Hyperhidrosis 1.4
Nervous system disorders Paraesthesia 1.4
Nervous system disorders Somnolence 1.4
Nervous system disorders Tremor 1.4
Nervous system disorders Insomnia 1.3
Gastrointestinal disorders Constipation
Gastrointestinal disorders Diarrhoea
Gastrointestinal disorders Diarrhoea 1.2
Gastrointestinal disorders Dry mouth
Gastrointestinal disorders Flatulence
Gastrointestinal disorders Nausea
Gastrointestinal disorders Vomiting
Nervous system disorders Agitation 1.1
Psychiatric disorders Anxiety 1.1
General disorders and administration site conditions Asthenia 1.1
Gastrointestinal disorders Constipation 1.1
Gastrointestinal disorders Diarrhoea 1.1
General disorders and administration site conditions Hyperhidrosis 1.1
Nervous system disorders Hyperkinesia 1.1
Gastrointestinal disorders Nausea
Nervous system disorders Tremor 1.1
Infections and infestations Vaginal infection 1.1
Vaginal inflammation 1.1
Respiratory, thoracic and mediastinal disorders Yawning 1.1
Nervous system disorders Abnormal dreams
Nervous system disorders Abnormal dreams 1.0
Nervous system disorders Agitation
Nervous system disorders Amnesia 1.0
Psychiatric disorders Anxiety
Musculoskeletal and connective tissue disorders Arthralgia
Musculoskeletal and connective tissue disorders Back pain
Infections and infestations Bronchitis 1.0
Cardiac disorders Chest pain
Cardiac disorders Chest pain 1.0
Nervous system disorders Confusional state 1.0
Gastrointestinal disorders Constipation
Respiratory, thoracic and mediastinal disorders Cough
Respiratory, thoracic and mediastinal disorders Cough 1.0
General disorders and administration site conditions Decreased appetite
General disorders and administration site conditions Decreased appetite 1.0
Psychiatric disorders Depression
Gastrointestinal disorders Diarrhoea 1.0
Nervous system disorders Disturbance in attention
Nervous system disorders Disturbance in attention 1.0
Psychiatric disorders Disturbance in sexual arousal
Psychiatric disorders Disturbance in sexual arousal 1.0
Cardiac disorders Dizziness 1.0
Gastrointestinal disorders Dry mouth
Gastrointestinal disorders Dry mouth 1.0
Gastrointestinal disorders Dyspepsia
Renal and urinary disorders Dysuria
Skin and subcutaneous tissue disorders Eczema 1.0
Reproductive system and breast disorders Ejaculation disorder
Psychiatric disorders Erectile dysfunction
General disorders and administration site conditions Feeling abnormal 1.0
Gastrointestinal disorders Flatulence 1.0
Metabolism and nutrition disorders Fluid retention
Metabolism and nutrition disorders Fluid retention 1.0
General disorders and administration site conditions Generalised oedema
General disorders and administration site conditions Generalised oedema 1.0
Genital disorder female
Gastrointestinal disorders Gingivitis 1.0
General disorders and administration site conditions Hyperhidrosis
General disorders and administration site conditions Hyperhidrosis 1.0
Immune system disorders Hypersensitivity
Musculoskeletal and connective tissue disorders Hypertonia
General disorders and administration site conditions Increased appetite
Injury, poisoning and procedural complications Injury
Psychiatric disorders Libido decreased
Psychiatric disorders Libido decreased 1.0
Reproductive system and breast disorders Menorrhagia
Reproductive system and breast disorders Menorrhagia 1.0
Reproductive system and breast disorders Menstrual disorder
Reproductive system and breast disorders Menstrual disorder 1.0
Social circumstances Mental disability
Social circumstances Mental disability 1.0
Nervous system disorders Migraine
Nervous system disorders Migraine 1.0
Musculoskeletal and connective tissue disorders Musculoskeletal discomfort
Nervous system disorders Myoclonus
Nervous system disorders Myoclonus 1.0
Psychiatric disorders Nervousness
General disorders and administration site conditions Pain
Nervous system disorders Paraesthesia
Nervous system disorders Paraesthesia 1.0
Renal and urinary disorders Pollakiuria
Reproductive system and breast disorders Reproductive tract disorder
Infections and infestations Rhinitis
Nervous system disorders Somnolence
Cardiac disorders Tachycardia
Cardiac disorders Tachycardia 1.0
Psychiatric disorders Tension
Gastrointestinal disorders Tooth disorder 1.0
Nervous system disorders Tremor
Nervous system disorders Tremor 1.0
Infections and infestations Urinary tract infection
Infections and infestations Vaginal infection
Infections and infestations Vaginal infection 1.0
Vaginal inflammation
Vaginal inflammation 1.0
Ear and labyrinth disorders Vertigo
Eye disorders Visual impairment
Eye disorders Visual impairment 1.0
Gastrointestinal disorders Vomiting
Gastrointestinal disorders Vomiting 1.0
Infections and infestations Vulvovaginal candidiasis
Infections and infestations Vulvovaginal candidiasis 1.0
Infections and infestations Vulvovaginal mycotic infection
Infections and infestations Vulvovaginal mycotic infection 1.0
Investigations Weight decreased 1.0
Investigations Weight increased
Investigations Weight increased 1.0
Respiratory, thoracic and mediastinal disorders Yawning
General disorders and administration site conditions Asthenia 0.9
Gastrointestinal disorders Diarrhoea 0.9
Nervous system disorders Headache
General disorders and administration site conditions Hyperhidrosis
Gastrointestinal disorders Nausea
Respiratory, thoracic and mediastinal disorders Yawning 0.9
Cardiac disorders Dizziness 0.8
Nervous system disorders Tremor 0.8
Nervous system disorders Somnolence
General disorders and administration site conditions Asthenia
General disorders and administration site conditions Decreased appetite 0.6
Nervous system disorders Disturbance in attention
Nervous system disorders Disturbance in attention 0.6
Cardiac disorders Dizziness
Cardiac disorders Dizziness 0.6
Gastrointestinal disorders Dry mouth 0.6
Reproductive system and breast disorders Ejaculation disorder
Social circumstances Mental disability
Social circumstances Mental disability 0.6
Gastrointestinal disorders Nausea
Nervous system disorders Somnolence
Nervous system disorders Agitation
General disorders and administration site conditions Asthenia
Gastrointestinal disorders Diarrhoea
Reproductive system and breast disorders Ejaculation disorder
Nervous system disorders Headache
Gastrointestinal disorders Nausea
General disorders and administration site conditions Asthenia
Gastrointestinal disorders Nausea
Gastrointestinal disorders Abdominal pain 0.3
Nervous system disorders Agitation 0.3
Gastrointestinal disorders Diarrhoea
Nervous system disorders Disturbance in attention
Nervous system disorders Disturbance in attention 0.3
Gastrointestinal disorders Dry mouth
Gastrointestinal disorders Flatulence
Gastrointestinal disorders Gastrointestinal pain 0.3
Nervous system disorders Headache 0.3
General disorders and administration site conditions Hyperhidrosis
Nervous system disorders Hyperkinesia 0.3
Nervous system disorders Insomnia
Social circumstances Mental disability
Gastrointestinal disorders Nausea
Nervous system disorders Paraesthesia
Nervous system disorders Paraesthesia 0.3
Nervous system disorders Somnolence
Psychiatric disorders Suicidal ideation 0.3
Nervous system disorders Tremor
Nervous system disorders Tremor 0.3
Infections and infestations Vaginal infection
Infections and infestations Vaginal infection 0.3
Vaginal inflammation
Vaginal inflammation 0.3
Gastrointestinal disorders Vomiting
Respiratory, thoracic and mediastinal disorders Yawning
General disorders and administration site conditions Asthenia
Gastrointestinal disorders Constipation
Gastrointestinal disorders Diarrhoea
Cardiac disorders Dizziness
Gastrointestinal disorders Dry mouth
Gastrointestinal disorders Flatulence
Nervous system disorders Headache
General disorders and administration site conditions Hyperhidrosis
Gastrointestinal disorders Nausea
Nervous system disorders Somnolence
Nervous system disorders Tremor
Gastrointestinal disorders Vomiting

Adverse Reactions

SOC By Demographic Distribution
System Organ Classification (SOC)
Relative Frequency (%)
Psychiatric disorders
23.19
Nervous system disorders
16.72
General disorders and administration site conditions
10.78
Cardiac disorders
5.89
Injury, poisoning and procedural complications
5.72
Congenital, familial and genetic disorders
4.93
Gastrointestinal disorders
4.19
Pregnancy, puerperium and perinatal conditions
3.94
Vascular disorders
3.83
Musculoskeletal and connective tissue disorders
3.56
Skin and subcutaneous tissue disorders
3.34
Respiratory, thoracic and mediastinal disorders
2.92

Cross References

Resources Reference
ChEBI 7944
ChEMBL CHEMBL1708
EPA CompTox DTXSID50228914
FDA SRS 3I3T11UD2S
SureChEMBL SCHEMBL33348
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