PAROXETINE MESYLATE

Search structure
Trade Names:
Synonyms:
Status: Approved (2003)
Entry Type: Small molecule
Molecule Category: Salt
UNII: M711N184JE
Parent Compound: PAROXETINE

Structure
InChI Key SHIJTGJXUHTGGZ-RVXRQPKJSA-N
Smile CS(=O)(=O)O.Fc1ccc([C@@H]2CCNC[C@H]2COc2ccc3c(c2)OCO3)cc1
InChI
InChI=1S/C19H20FNO3.CH4O3S/c20-15-3-1-13(2-4-15)17-7-8-21-10-14(17)11-22-16-5-6-18-19(9-16)24-12-23-18;1-5(2,3)4/h1-6,9,14,17,21H,7-8,10-12H2;1H3,(H,2,3,4)/t14-,17-;/m0./s1

Physicochemical Descriptors

Property Name Value
Molecular Formula C20H24FNO6S
Molecular Weight 425.48
AlogP 3.33
Hydrogen Bond Acceptor 4.0
Hydrogen Bond Donor 1.0
Number of Rotational Bond 4.0
Polar Surface Area 39.72
Molecular species BASE
Aromatic Rings 2.0
Heavy Atoms 24.0

Pharmacology

Action Mechanism of Action Reference
INHIBITOR Serotonin transporter inhibitor DailyMed

Indications

Mesh Heading Maximum Phase Mesh ID Reference
Menopause 3 D008593 ClinicalTrials
Hot Flashes 3 D019584 ClinicalTrials

Related Entries

Scaffolds

Parent

Adverse Reactions

SOC By Demographic Distribution
System Organ Classification (SOC)
Relative Frequency (%)
Psychiatric disorders
19.15
General disorders and administration site conditions
18.37
Nervous system disorders
15.84
Injury, poisoning and procedural complications
6.85
Vascular disorders
5.59
Gastrointestinal disorders
4.2
Cardiac disorders
3.78
Pregnancy, puerperium and perinatal conditions
3.54
Skin and subcutaneous tissue disorders
3.05
Musculoskeletal and connective tissue disorders
2.71
Reproductive system and breast disorders
2.62
Respiratory, thoracic and mediastinal disorders
2.37
Congenital, familial and genetic disorders
2.35

Cross References

Resources Reference
ChEBI 7936
ChEMBL CHEMBL1200609
FDA SRS M711N184JE
Guide to Pharmacology 4561
KEGG C07415
PDB 8PR
PubChem 9845306
SureChEMBL SCHEMBL143905
ZINC ZINC00527386
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