PERAMIVIR

Search structure
Trade Names:
Synonyms:
Status: Approved (2014)
Entry Type: Small molecule
Molecule Category: UNKNOWN
ATC: J05AH03
UNII: QW7Y7ZR15U

Structure
InChI Key XRQDFNLINLXZLB-CKIKVBCHSA-N
Smile CCC(CC)[C@H](NC(C)=O)[C@@H]1[C@H](O)[C@@H](C(=O)O)C[C@H]1NC(=N)N
InChI
InChI=1S/C15H28N4O4/c1-4-8(5-2)12(18-7(3)20)11-10(19-15(16)17)6-9(13(11)21)14(22)23/h8-13,21H,4-6H2,1-3H3,(H,18,20)(H,22,23)(H4,16,17,19)/t9-,10+,11+,12-,13+/m0/s1

Physicochemical Descriptors

Property Name Value
Molecular Formula C15H34N4O7
Molecular Weight 382.46
AlogP -0.14
Hydrogen Bond Acceptor 4.0
Hydrogen Bond Donor 6.0
Number of Rotational Bond 7.0
Polar Surface Area 148.53
Molecular species ZWITTERION
Aromatic Rings 0.0
Heavy Atoms 23.0

Pharmacology

Action Mechanism of Action Reference
INHIBITOR Neuraminidase inhibitor FDA
Targets EC50(nM) IC50(nM) Kd(nM) Ki(nM) Inhibition(%)
Enzyme Hydrolase
- 0-10000 - 1 -
Enzyme
- 0-10000 - 1 -

Indications

Mesh Heading Maximum Phase Mesh ID Reference
Influenza, Human 3 D007251 ClinicalTrials

Adverse Reactions

SOC By Demographic Distribution
System Organ Classification (SOC)
Relative Frequency (%)
Respiratory, thoracic and mediastinal disorders
10.95
Vascular disorders
10.52
Investigations
8.65
General disorders and administration site conditions
8.5
Nervous system disorders
8.5
Infections and infestations
6.63
Cardiac disorders
6.34
Hepatobiliary disorders
5.62
Renal and urinary disorders
5.19
Immune system disorders
4.61
Gastrointestinal disorders
3.89
Skin and subcutaneous tissue disorders
3.6
Injury, poisoning and procedural complications
3.46
Blood and lymphatic system disorders
3.17
Metabolism and nutrition disorders
2.88
Musculoskeletal and connective tissue disorders
2.45
Psychiatric disorders
2.16

Cross References

Resources Reference
CAS NUMBER 330600-85-6
ChEMBL CHEMBL3989402
EPA CompTox DTXSID60146317
FDA SRS QW7Y7ZR15U
PubChem 11954371
CAS NUMBER 330600-85-6
ChEBI 85202
ChEMBL CHEMBL139367
DrugBank DB06614
DrugCentral 4823
FDA SRS IDL9Q29886
PDB BCZ
PubChem 11954371
SureChEMBL SCHEMBL744373
ZINC ZINC000003981610
CONTENTS