PEXIDARTINIB HYDROCHLORIDE

Search structure
Trade Names:
Synonyms:
Status: Approved (2019)
Entry Type: Small molecule
Molecule Category: Salt
UNII: YS6WAI3XN7
Parent Compound: PEXIDARTINIB

Structure
InChI Key CJLUYLRKLUYCEK-UHFFFAOYSA-N
Smile Cl.FC(F)(F)c1ccc(CNc2ccc(Cc3c[nH]c4ncc(Cl)cc34)cn2)cn1
InChI
InChI=1S/C20H15ClF3N5.ClH/c21-15-6-16-14(10-28-19(16)29-11-15)5-12-2-4-18(26-7-12)27-9-13-1-3-17(25-8-13)20(22,23)24;/h1-4,6-8,10-11H,5,9H2,(H,26,27)(H,28,29);1H

Physicochemical Descriptors

Property Name Value
Molecular Formula C20H16Cl2F3N5
Molecular Weight 454.28
AlogP 5.23
Hydrogen Bond Acceptor 4.0
Hydrogen Bond Donor 2.0
Number of Rotational Bond 5.0
Polar Surface Area 66.49
Molecular species NEUTRAL
Aromatic Rings 4.0
Heavy Atoms 29.0

Pharmacology

Action Mechanism of Action Reference
INHIBITOR Macrophage colony stimulating factor receptor inhibitor FDA PubMed PubMed

Indications

Mesh Heading Maximum Phase Mesh ID Reference

Related Entries

Scaffolds

Parent

Cross References

Resources Reference
ChEMBL CHEMBL3989973
FDA SRS YS6WAI3XN7
PubChem 73053710
SureChEMBL SCHEMBL18207396
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