| Trade Names: | |
| Synonyms: | |
| Status: | Approved (1952) |
| Entry Type: | Small molecule |
| Molecule Category: | Salt |
| UNII: | 04JA59TNSJ |
| Parent Compound: | PHENYLEPHRINE |
Structure
| InChI Key | OCYSGIYOVXAGKQ-FVGYRXGTSA-N |
|---|---|
| Smile | |
| InChI |
|
Physicochemical Descriptors
| Property Name | Value |
|---|---|
| Molecular Formula | C9H14ClNO2 |
| Molecular Weight | 203.67 |
| AlogP | 0.65 |
| Hydrogen Bond Acceptor | 3.0 |
| Hydrogen Bond Donor | 3.0 |
| Number of Rotational Bond | 3.0 |
| Polar Surface Area | 52.49 |
| Molecular species | BASE |
| Aromatic Rings | 1.0 |
| Heavy Atoms | 12.0 |
Pharmacology
| Action | Mechanism of Action | Reference |
|---|---|---|
| AGONIST | Adrenergic receptor alpha-1 agonist | ISBN |
| Targets | EC50(nM) | IC50(nM) | Kd(nM) | Ki(nM) | Inhibition(%) | |
|---|---|---|---|---|---|---|
|
Transporter
Electrochemical transporter
SLC superfamily of solute carriers
SLC21/SLCO family of organic anion transporting polypeptides
|
- | - | - | - | 106 |
Indications
| Mesh Heading | Maximum Phase | Mesh ID | Reference |
|---|---|---|---|
| Common Cold | 4 | D003139 | ClinicalTrials |
| Cataract | 3 | D002386 | ClinicalTrials |
| Rhinitis, Vasomotor | 3 | D012223 | ClinicalTrials |
| Respiratory Tract Infections | 3 | D012141 | ClinicalTrials |
| Acute Lung Injury | 2 | D055371 | ClinicalTrials |
| Stomach Neoplasms | 2 | D013274 | ClinicalTrials |
| Infections | 1 | D007239 | ClinicalTrials |
| Rhinitis | 1 | D012220 | ClinicalTrials |
| Cardiovascular Diseases | 1 | D002318 | ClinicalTrials |
| Arrhythmias, Cardiac | 1 | D001145 | ClinicalTrials |
Related Entries
Adverse Reactions
System Organ Classification (SOC)
Cross References
| Resources | Reference |
|---|---|
| ChEBI | 8094 |
| ChEMBL | CHEMBL1200339 |
| EPA CompTox | DTXSID3021142 |
| FDA SRS | 04JA59TNSJ |
| PubChem | 441279 |
| SureChEMBL | SCHEMBL24654 |
CONTENTS