PINACIDIL

Search structure
Trade Names:
Synonyms:
Status: Approved (1989)
Entry Type: Small molecule
Molecule Category: UNKNOWN
ATC: C02DG01
UNII: 7B0ZZH8P2W

Structure
InChI Key IVVNZDGDKPTYHK-UHFFFAOYSA-N
Smile CC(N/C(=N\C#N)Nc1ccncc1)C(C)(C)C
InChI
InChI=1S/C13H19N5/c1-10(13(2,3)4)17-12(16-9-14)18-11-5-7-15-8-6-11/h5-8,10H,1-4H3,(H2,15,16,17,18)

Physicochemical Descriptors

Property Name Value
Molecular Formula C13H19N5
Molecular Weight 245.33
AlogP 2.35
Hydrogen Bond Acceptor 3.0
Hydrogen Bond Donor 2.0
Number of Rotational Bond 2.0
Polar Surface Area 73.1
Molecular species NEUTRAL
Aromatic Rings 1.0
Heavy Atoms 18.0

Pharmacology

Action Mechanism of Action Reference
OPENER Sulfonylurea receptor 2, Kir6.2 opener PubMed PubMed
Targets EC50(nM) IC50(nM) Kd(nM) Ki(nM) Inhibition(%)
Ion channel Voltage-gated ion channel Potassium channels Inwardly rectifying potassium channel
- - - 320 -
Transporter Electrochemical transporter SLC superfamily of solute carriers SLC21/SLCO family of organic anion transporting polypeptides
- - - - 91
Transporter Primary active transporter ATP-binding cassette ABCC subfamily
3540 - - 320 -

Indications

Mesh Heading Maximum Phase Mesh ID Reference

Cross References

Resources Reference
CAS NUMBER 60560-33-0
ChEBI 34923
ChEMBL CHEMBL1200338
EPA CompTox DTXSID4045682
FDA SRS 7B0ZZH8P2W
Guide to Pharmacology 2412
KEGG C13729
PubChem 55329
SureChEMBL SCHEMBL65786
ZINC ZINC18189761
CAS NUMBER 60560-33-0
ChEBI 91706
ChEMBL CHEMBL1159
DrugBank DB06762
DrugCentral 2173
EPA CompTox DTXSID7048249
FDA SRS BB4UGO5K0D
Guide to Pharmacology 2412
PubChem 55329
SureChEMBL SCHEMBL65787
ZINC ZINC18189761
CONTENTS