DrugMapper


Trade Names:	PINDOLOL VISKEN
Synonyms:	APO-PINDOL BETADREN BETAPINDOL BLOCKLIN-L CALVISKEN CARVISKEN DECRETEN DL-LB-46 DL-PINDOLOL DURAPINDOL GLAUCO-VISKEN (+/-)-LB-46 LB-46 NSC-757276 PECTOBLOC PINBETOL PINDOLOL COMPONENT OF VISKAZIDE PRINODOLOL PYNASTIN (RS)-PINDOLOL VISKEN
Status:	Approved (1982)
Entry Type:	Small molecule
Molecule Category:	Parent
ATC:	C07AA03
UNII:	BJ4HF6IU1D


InChI Key	JZQKKSLKJUAGIC-UHFFFAOYSA-N
Smile	CC(C)NCC(O)COc1cccc2[nH]ccc12
InChI	InChI=1S/C14H20N2O2/c1-10(2)16-8-11(17)9-18-14-5-3-4-13-12(14)6-7-15-13/h3-7,10-11,15-17H,8-9H2,1-2H3

Physicochemical Descriptors

Property Name	Value
Molecular Formula	C14H20N2O2
Molecular Weight	248.33
AlogP	1.91
Hydrogen Bond Acceptor	3.0
Hydrogen Bond Donor	3.0
Number of Rotational Bond	6.0
Polar Surface Area	57.28
Molecular species	BASE
Aromatic Rings	2.0
Heavy Atoms	18.0

Action	Mechanism of Action	Reference
PARTIAL AGONIST	Beta-1 adrenergic receptor partial agonist

	Primary Target
β₁-adrenoceptor
β₂-adrenoceptor

Targets	EC50(nM)	IC50(nM)	Kd(nM)	Ki(nM)	Inhibition(%)
Enzyme Hydrolase	-	-	-	-
Enzyme Transferase	-	-	-	-	11.03
Enzyme	-	-	-	-
Ion channel Ligand-gated ion channel 5HT3 receptor	-	-	-	-
Membrane receptor Family A G protein-coupled receptor Peptide receptor (family A GPCR) Short peptide receptor (family A GPCR) Opioid receptor	-	-	-	-	16.79
Membrane receptor Family A G protein-coupled receptor Small molecule receptor (family A GPCR) Monoamine receptor Acetylcholine receptor	-	-	-	-	10.47
Membrane receptor Family A G protein-coupled receptor Small molecule receptor (family A GPCR) Monoamine receptor Adrenergic receptor	-	0.549-2.192	0.537-0.6607	0.32-4.91
Membrane receptor Family A G protein-coupled receptor Small molecule receptor (family A GPCR) Monoamine receptor Dopamine receptor	-	-	-	1661.88	26.33
Membrane receptor Family A G protein-coupled receptor Small molecule receptor (family A GPCR) Monoamine receptor Histamine receptor	-	-	-	-
Membrane receptor Family A G protein-coupled receptor Small molecule receptor (family A GPCR) Monoamine receptor Serotonin receptor	27	48	63.1	22.4-153.64	20.01
Membrane receptor	27	0.549-2.192	0.537-0.6607	22.4-153.64
Transporter Electrochemical transporter SLC superfamily of solute carriers SLC06 neurotransmitter transporter family	-	-	-	-	21.3
Transporter Electrochemical transporter SLC superfamily of solute carriers SLC21/SLCO family of organic anion transporting polypeptides	-	-	-	-	24.5-97.58

Mesh Heading	Maximum Phase	Mesh ID	Reference
Depressive Disorder, Major	2	D003865	ClinicalTrials
Depressive Disorder, Major	2	D003865	ClinicalTrials
Depressive Disorder	2	D003866	ClinicalTrials

MCS

Target Level :

Level 3

Level 4

Level 5

Level 6

Extend :

Indication

Mechanism of Action

Primary Target

Target Level

Mixture

Side Effects from Label

Side Effects (PT)

Side effects	Relative Frequency (%)	Labels
Cardiac disorders Dizziness	11.0
Nervous system disorders Insomnia
Nervous system disorders Insomnia	10.0
Musculoskeletal and connective tissue disorders Musculoskeletal discomfort	10.0
Musculoskeletal and connective tissue disorders Myalgia	10.0
Cardiac disorders Dizziness	9.0
Musculoskeletal and connective tissue disorders Musculoskeletal discomfort	9.0
Musculoskeletal and connective tissue disorders Myalgia	9.0
General disorders and administration site conditions Asthenia	8.0
General disorders and administration site conditions Fatigue	8.0
Musculoskeletal and connective tissue disorders Musculoskeletal discomfort
Musculoskeletal and connective tissue disorders Musculoskeletal discomfort	8.0
Musculoskeletal and connective tissue disorders Myalgia
Musculoskeletal and connective tissue disorders Myalgia	8.0
Musculoskeletal and connective tissue disorders Arthralgia	7.0
Musculoskeletal and connective tissue disorders Musculoskeletal discomfort	7.0
Psychiatric disorders Nervousness	7.0
Psychiatric disorders Tension	7.0
Cardiac disorders Dyspnoea
Cardiac disorders Dyspnoea	6.0
General disorders and administration site conditions Oedema	6.0
Nervous system disorders Paraesthesia
Nervous system disorders Paraesthesia	6.0
Gastrointestinal disorders Abdominal discomfort
Gastrointestinal disorders Abdominal discomfort	5.0
Cardiac disorders Dyspnoea	5.0
Gastrointestinal disorders Nausea	5.0
Psychiatric disorders Nervousness
Psychiatric disorders Nervousness	5.0
Psychiatric disorders Tension
Psychiatric disorders Tension	5.0
Gastrointestinal disorders Abdominal discomfort	4.0
Musculoskeletal and connective tissue disorders Arthralgia
Musculoskeletal and connective tissue disorders Arthralgia	4.0
General disorders and administration site conditions Asthenia
General disorders and administration site conditions Asthenia	4.0
Cardiac disorders Dyspnoea	4.0
General disorders and administration site conditions Fatigue
General disorders and administration site conditions Fatigue	4.0
Musculoskeletal and connective tissue disorders Musculoskeletal discomfort
Musculoskeletal and connective tissue disorders Musculoskeletal discomfort	4.0
Cardiac disorders Chest pain
Cardiac disorders Chest pain	3.0
Nervous system disorders Insomnia	3.0
Musculoskeletal and connective tissue disorders Muscle spasms	3.0
Psychiatric disorders Nervousness	3.0
General disorders and administration site conditions Oedema	3.0
Nervous system disorders Paraesthesia	3.0
Psychiatric disorders Tension	3.0
General disorders and administration site conditions Asthenia	2.0
Gastrointestinal disorders Nausea	2.0
General disorders and administration site conditions Asthenia
General disorders and administration site conditions Asthenia	1.0
Cardiac disorders Cardiac failure	1.0
Cardiac disorders Chest pain	1.0
Skin and subcutaneous tissue disorders Dermatitis
Skin and subcutaneous tissue disorders Dermatitis	1.0
Cardiac disorders Dizziness
Cardiac disorders Dizziness	1.0
Psychiatric disorders Hallucination	1.0
Musculoskeletal and connective tissue disorders Muscle spasms	1.0
Gastrointestinal disorders Nausea
Gastrointestinal disorders Nausea	1.0
General disorders and administration site conditions Oedema
General disorders and administration site conditions Oedema	1.0
Cardiac disorders Palpitations	1.0
Nervous system disorders Paraesthesia	1.0
Skin and subcutaneous tissue disorders Pruritus	1.0
Skin and subcutaneous tissue disorders Rash
Skin and subcutaneous tissue disorders Rash	1.0

Adverse Reactions

SOC By Demographic Distribution

System Organ Classification (SOC)

	Relative Frequency (%)
Cardiac disorders	22.22
General disorders and administration site conditions	16.67
Investigations	11.11
Respiratory, thoracic and mediastinal disorders	8.33
Product issues	8.33
Gastrointestinal disorders	5.56
Infections and infestations	5.56
Musculoskeletal and connective tissue disorders	5.56
Skin and subcutaneous tissue disorders	5.56
Injury, poisoning and procedural complications	2.78
Nervous system disorders	2.78
Psychiatric disorders	2.78
Renal and urinary disorders	2.78

Cross References

Resources	Reference
CAS NUMBER	13523-86-9
ChEBI	8214
ChEMBL	CHEMBL500
DrugBank	DB00960
DrugCentral	2176
EPA CompTox	DTXSID8023476
FDA SRS	BJ4HF6IU1D
Human Metabolome Database	HMDB15095
Guide to Pharmacology	91
KEGG	C07445
PharmGKB	PA450966
PubChem	4828
SureChEMBL	SCHEMBL5219
ZINC	ZINC00056646

PINDOLOL

Structure

Physicochemical Descriptors

Pharmacology

Indications

Related Entries

MCS

Side Effects from Label

Adverse Reactions

Cross References


Active Pharmaceutical Ingredients (APIs) Scaffolds	Exact Similarity SubStructure	Threshold (%) >= 70