PREDNICARBATE

Search structure
Trade Names:
Synonyms:
Status: Approved (1991)
Entry Type: Small molecule
Molecule Category: UNKNOWN Prodrug
ATC: D07AC18
UNII: V901LV1K7D

Structure
InChI Key FNPXMHRZILFCKX-KAJVQRHHSA-N
Smile CCOC(=O)O[C@]1(C(=O)COC(=O)CC)CC[C@H]2[C@@H]3CCC4=CC(=O)C=C[C@]4(C)[C@H]3[C@@H](O)C[C@@]21C
InChI
InChI=1S/C27H36O8/c1-5-22(31)34-15-21(30)27(35-24(32)33-6-2)12-10-19-18-8-7-16-13-17(28)9-11-25(16,3)23(18)20(29)14-26(19,27)4/h9,11,13,18-20,23,29H,5-8,10,12,14-15H2,1-4H3/t18-,19-,20-,23+,25-,26-,27-/m0/s1

Physicochemical Descriptors

Property Name Value
Molecular Formula C27H36O8
Molecular Weight 488.58
AlogP 3.7
Hydrogen Bond Acceptor 8.0
Hydrogen Bond Donor 1.0
Number of Rotational Bond 6.0
Polar Surface Area 116.2
Molecular species NEUTRAL
Aromatic Rings 0.0
Heavy Atoms 35.0

Pharmacology

Action Mechanism of Action Reference
AGONIST Glucocorticoid receptor agonist PubMed PubMed

Indications

Mesh Heading Maximum Phase Mesh ID Reference
Tinea Pedis 2 D014008 ClinicalTrials
Eczema 2 D004485 ClinicalTrials
Candidiasis 2 D002177 ClinicalTrials
Psoriasis 1 D011565 ClinicalTrials

Related Entries

MCS

Scaffolds

Adverse Reactions

SOC By Demographic Distribution
System Organ Classification (SOC)
Relative Frequency (%)
Skin and subcutaneous tissue disorders
20.69
General disorders and administration site conditions
15.52
Infections and infestations
15.52
Injury, poisoning and procedural complications
12.07
Immune system disorders
8.62
Investigations
6.9
Metabolism and nutrition disorders
3.45
Pregnancy, puerperium and perinatal conditions
3.45
Product issues
3.45

Cross References

Resources Reference
CAS NUMBER 73771-04-7
ChEBI 135791
ChEMBL CHEMBL1200386
DrugBank DB01130
DrugCentral 2243
EPA CompTox DTXSID9045502
FDA SRS V901LV1K7D
Guide to Pharmacology 7605
PubChem 6714002
SureChEMBL SCHEMBL3941
ZINC ZINC000003938652
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