PROCAINAMIDE HYDROCHLORIDE

Search structure
Trade Names:
Synonyms:
Status: Approved (1950)
Entry Type: Small molecule
Molecule Category: Salt
UNII: SI4064O0LX
Parent Compound: PROCAINAMIDE

Structure
InChI Key ABTXGJFUQRCPNH-UHFFFAOYSA-N
Smile CCN(CC)CCNC(=O)c1ccc(N)cc1.Cl
InChI
InChI=1S/C13H21N3O.ClH/c1-3-16(4-2)10-9-15-13(17)11-5-7-12(14)8-6-11;/h5-8H,3-4,9-10,14H2,1-2H3,(H,15,17);1H

Physicochemical Descriptors

Property Name Value
Molecular Formula C13H22ClN3O
Molecular Weight 271.79
AlogP 1.34
Hydrogen Bond Acceptor 3.0
Hydrogen Bond Donor 2.0
Number of Rotational Bond 6.0
Polar Surface Area 58.36
Molecular species BASE
Aromatic Rings 1.0
Heavy Atoms 17.0

Pharmacology

Action Mechanism of Action Reference
BLOCKER Sodium channel alpha subunit blocker ISBN
Targets EC50(nM) IC50(nM) Kd(nM) Ki(nM) Inhibition(%)
Transporter Electrochemical transporter SLC superfamily of solute carriers SLC21/SLCO family of organic anion transporting polypeptides
- - - - 104

Indications

Mesh Heading Maximum Phase Mesh ID Reference
Atrial Fibrillation 3 D001281 ClinicalTrials
Heart Failure 3 D006333 ClinicalTrials

Related Entries

Parent

Adverse Reactions

SOC By Demographic Distribution
System Organ Classification (SOC)
Relative Frequency (%)
Immune system disorders
37.76
Skin and subcutaneous tissue disorders
18.37
Vascular disorders
11.22
Musculoskeletal and connective tissue disorders
10.2
General disorders and administration site conditions
6.12
Cardiac disorders
4.08
Blood and lymphatic system disorders
3.06
Hepatobiliary disorders
3.06
Injury, poisoning and procedural complications
3.06
Investigations
2.04

Cross References

Resources Reference
ChEBI 8429
ChEMBL CHEMBL605
EPA CompTox DTXSID2049422
FDA SRS SI4064O0LX
Guide to Pharmacology 4811
KEGG C07401
PubChem 66068
SureChEMBL SCHEMBL40758
ZINC ZINC01530756
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