PROCHLORPERAZINE EDISYLATE

Search structure
Trade Names:
Synonyms:
Status: Approved (1957)
Entry Type: Small molecule
Molecule Category: Salt
UNII: PG20W5VQZS
Parent Compound: PROCHLORPERAZINE

Structure
InChI Key SWOUGRBFXFILIB-UHFFFAOYSA-N
Smile CN1CCN(CCCN2c3ccccc3Sc3ccc(Cl)cc32)CC1.O=S(=O)(O)CCS(=O)(=O)O
InChI
InChI=1S/C20H24ClN3S.C2H6O6S2/c1-22-11-13-23(14-12-22)9-4-10-24-17-5-2-3-6-19(17)25-20-8-7-16(21)15-18(20)24;3-9(4,5)1-2-10(6,7)8/h2-3,5-8,15H,4,9-14H2,1H3;1-2H2,(H,3,4,5)(H,6,7,8)

Physicochemical Descriptors

Property Name Value
Molecular Formula C22H30ClN3O6S3
Molecular Weight 564.15
AlogP 4.58
Hydrogen Bond Acceptor 4.0
Hydrogen Bond Donor 0.0
Number of Rotational Bond 4.0
Polar Surface Area 9.72
Molecular species NEUTRAL
Aromatic Rings 2.0
Heavy Atoms 25.0

Pharmacology

Action Mechanism of Action Reference
ANTAGONIST Dopamine D2 receptor antagonist
Targets EC50(nM) IC50(nM) Kd(nM) Ki(nM) Inhibition(%)
Enzyme Transferase
- - - - 33.03
Epigenetic regulator Eraser Histone deacetylase HDAC class IIb
- - - - -27.45-5.74
Transporter Electrochemical transporter SLC superfamily of solute carriers SLC21/SLCO family of organic anion transporting polypeptides
- - - - 110.92
Unclassified protein
- 29100 - - -

Related Entries

Scaffolds

Parent

Adverse Reactions

SOC By Demographic Distribution
System Organ Classification (SOC)
Relative Frequency (%)
Nervous system disorders
23.53
Psychiatric disorders
17.65
General disorders and administration site conditions
11.76
Immune system disorders
11.76
Gastrointestinal disorders
5.88
Injury, poisoning and procedural complications
5.88
Investigations
5.88
Respiratory, thoracic and mediastinal disorders
5.88
Skin and subcutaneous tissue disorders
5.88
Vascular disorders
5.88

Cross References

Resources Reference
ChEMBL CHEMBL1201154
EPA CompTox DTXSID4074483
FDA SRS PG20W5VQZS
PubChem 91499
SureChEMBL SCHEMBL40855
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