| Trade Names: | |
| Synonyms: | |
| Status: | Approved (1971) |
| Entry Type: | Small molecule |
| Molecule Category: | Parent Prodrug |
| ATC: | J04AK01 |
| UNII: | 2KNI5N06TI |
Structure
| InChI Key | IPEHBUMCGVEMRF-UHFFFAOYSA-N |
|---|---|
| Smile | |
| InChI |
|
Physicochemical Descriptors
| Property Name | Value |
|---|---|
| Molecular Formula | C5H5N3O |
| Molecular Weight | 123.11 |
| AlogP | -0.42 |
| Hydrogen Bond Acceptor | 3.0 |
| Hydrogen Bond Donor | 1.0 |
| Number of Rotational Bond | 1.0 |
| Polar Surface Area | 68.87 |
| Molecular species | NEUTRAL |
| Aromatic Rings | 1.0 |
| Heavy Atoms | 9.0 |
Pharmacology
| Targets | EC50(nM) | IC50(nM) | Kd(nM) | Ki(nM) | Inhibition(%) | |
|---|---|---|---|---|---|---|
|
Transporter
Electrochemical transporter
SLC superfamily of solute carriers
SLC21/SLCO family of organic anion transporting polypeptides
|
- | - | - | - | 117 |
Indications
| Mesh Heading | Maximum Phase | Mesh ID | Reference |
|---|---|---|---|
| Tuberculosis, Pulmonary | 4 | D014397 | ClinicalTrials |
| Tuberculosis, Multidrug-Resistant | 3 | D018088 | ClinicalTrials |
| Tuberculosis, Multidrug-Resistant | 3 | D018088 | ClinicalTrials |
| Acquired Immunodeficiency Syndrome | 2 | D000163 | ClinicalTrials |
| HIV Infections | 1 | D015658 | ClinicalTrials |
| Osteomyelitis | 0 | D010019 | ClinicalTrials |
Related Entries
Adverse Reactions
System Organ Classification (SOC)
Cross References
| Resources | Reference |
|---|---|
| CAS NUMBER | 98-96-4 |
| ChEBI | 45285 |
| ChEMBL | CHEMBL614 |
| DrugBank | DB00339 |
| DrugCentral | 2328 |
| EPA CompTox | DTXSID9021215 |
| FDA SRS | 2KNI5N06TI |
| Human Metabolome Database | HMDB0014483 |
| Guide to Pharmacology | 7287 |
| KEGG | C01956 |
| PDB | PZA |
| PharmGKB | PA451182 |
| PubChem | 1046 |
| SureChEMBL | SCHEMBL24102 |
| ZINC | ZINC000000002005 |
CONTENTS