RAMUCIRUMAB

Search structure
Trade Names:
Synonyms:
Status: Approved (2014)
Entry Type: Antibody
Molecule Category: UNKNOWN
ATC: L01XC21
UNII: D99YVK4L0X

Pharmacology

Action Mechanism of Action Reference
INHIBITOR Vascular endothelial growth factor receptor 2 inhibitor
Primary Target
kinase insert domain receptor

Indications

Mesh Heading Maximum Phase Mesh ID Reference
Stomach Neoplasms 4 D013274 ClinicalTrials
Stomach Neoplasms 4 D013274 ClinicalTrials
Carcinoma, Non-Small-Cell Lung 4 D002289 ClinicalTrials
Neoplasms 4 D009369 ClinicalTrials
Stomach Neoplasms 4 D013274 ClinicalTrials
Colorectal Neoplasms 3 D015179 ClinicalTrials
Urinary Bladder Neoplasms 3 D001749 ClinicalTrials
Breast Neoplasms 3 D001943 ClinicalTrials
Colorectal Neoplasms 3 D015179 ClinicalTrials
Carcinoma, Hepatocellular 3 D006528 ClinicalTrials
Cholangiocarcinoma 2 D018281 ClinicalTrials
Carcinoma, Squamous Cell 2 D002294 ClinicalTrials
Thymoma 2 D013945 ClinicalTrials
Rectal Neoplasms 2 D012004 ClinicalTrials
Glioblastoma 2 D005909 ClinicalTrials
Adenocarcinoma 2 D000230 ClinicalTrials
Carcinoma, Renal Cell 2 D002292 ClinicalTrials
Pancreatic Neoplasms 2 D010190 ClinicalTrials
Melanoma 2 D008545 ClinicalTrials
Melanoma 2 D008545 ClinicalTrials
Esophageal Neoplasms 2 D004938 ClinicalTrials
Carcinoid Tumor 2 D002276 ClinicalTrials
Carcinoma, Squamous Cell 2 D002294 ClinicalTrials
Mesothelioma 2 D008654 ClinicalTrials
Esophageal Neoplasms 2 D004938 ClinicalTrials
Thymoma 2 D013945 ClinicalTrials
Cholangiocarcinoma 2 D018281 ClinicalTrials
Mesothelioma, Malignant 2 D000086002 ClinicalTrials
Head and Neck Neoplasms 2 D006258 ClinicalTrials
Adenocarcinoma 2 D000230 ClinicalTrials
Lung Neoplasms 2 D008175 ClinicalTrials
Biliary Tract Neoplasms 2 D001661 ClinicalTrials
Gallbladder Neoplasms 2 D005706 ClinicalTrials
Esophageal Neoplasms 2 D004938 ClinicalTrials
Prostatic Neoplasms, Castration-Resistant 2 D064129 ClinicalTrials
Colonic Neoplasms 2 D003110 ClinicalTrials
Lung Neoplasms 2 D008175 ClinicalTrials
Desmoplastic Small Round Cell Tumor 1 D058405 ClinicalTrials
Glioma 1 D005910 ClinicalTrials
Lymphoma, Mantle-Cell 1 D020522 ClinicalTrials
Lymphoma, Non-Hodgkin 1 D008228 ClinicalTrials
Sarcoma, Synovial 1 D013584 ClinicalTrials

Adverse Reactions

SOC By Demographic Distribution
System Organ Classification (SOC)
Relative Frequency (%)
Gastrointestinal disorders
12.57
General disorders and administration site conditions
11.69
Vascular disorders
11.43
Respiratory, thoracic and mediastinal disorders
8.47
Investigations
6.65
Neoplasms benign, malignant and unspecified (incl cysts and polyps)
6.37
Blood and lymphatic system disorders
5.05
Infections and infestations
4.53
Nervous system disorders
4.49
Injury, poisoning and procedural complications
4.32
Cardiac disorders
4.24
Immune system disorders
3.95
Skin and subcutaneous tissue disorders
3.8
Metabolism and nutrition disorders
3.31
Renal and urinary disorders
2.73
Hepatobiliary disorders
2.66

Cross References

Resources Reference
CAS NUMBER 947687-13-0
ChEMBL CHEMBL1743062
FDA SRS D99YVK4L0X
Guide to Pharmacology 7390
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