| Trade Names: | |
| Synonyms: | |
| Status: | Approved (1994) |
| Entry Type: | Small molecule |
| Molecule Category: | UNKNOWN |
| ATC: | H02AB12 |
| UNII: | O7M2E4264D |
Structure
| InChI Key | QTTRZHGPGKRAFB-OOKHYKNYSA-N |
|---|---|
| Smile | |
| InChI |
|
Physicochemical Descriptors
| Property Name | Value |
|---|---|
| Molecular Formula | C24H34O3 |
| Molecular Weight | 370.53 |
| AlogP | 4.5 |
| Hydrogen Bond Acceptor | 3.0 |
| Hydrogen Bond Donor | 1.0 |
| Number of Rotational Bond | 2.0 |
| Polar Surface Area | 54.37 |
| Molecular species | NEUTRAL |
| Aromatic Rings | 0.0 |
| Heavy Atoms | 27.0 |
Pharmacology
| Action | Mechanism of Action | Reference |
|---|---|---|
| AGONIST | Glucocorticoid receptor agonist | PubMed |
| Targets | EC50(nM) | IC50(nM) | Kd(nM) | Ki(nM) | Inhibition(%) | |
|---|---|---|---|---|---|---|
|
Transcription factor
Nuclear receptor
Nuclear hormone receptor subfamily 1
Nuclear hormone receptor subfamily 1 group I
Nuclear hormone receptor subfamily 1 group I member 2
|
400-4000 | - | - | - | - |
Indications
| Mesh Heading | Maximum Phase | Mesh ID | Reference |
|---|---|---|---|
| Dry Eye Syndromes | 3 | D015352 | ClinicalTrials |
Related Entries
MCS
Scaffolds
Adverse Reactions
System Organ Classification (SOC)
Cross References
| Resources | Reference |
|---|---|
| CAS NUMBER | 49697-38-3 |
| ChEBI | 135566 |
| ChEMBL | CHEMBL1200617 |
| DrugBank | DB00896 |
| DrugCentral | 2384 |
| FDA SRS | O7M2E4264D |
| Guide to Pharmacology | 7099 |
| PubChem | 5311412 |
| SureChEMBL | SCHEMBL445300 |
| ZINC | ZINC000003945984 |
CONTENTS