RITUXIMAB

Search structure
Trade Names:
Synonyms:
Status: Approved (1997)
Entry Type: Antibody
Molecule Category: Parent
ATC: L01XC02
UNII: 4F4X42SYQ6

Pharmacology

Action Mechanism of Action Reference
BINDING AGENT B-lymphocyte antigen CD20 binding agent
Primary Target
CD20 (membrane-spanning 4-domains, subfamily A, member 1)

Indications

Mesh Heading Maximum Phase Mesh ID Reference
Pemphigus 4 D010392 ClinicalTrials
Precursor Cell Lymphoblastic Leukemia-Lymphoma 4 D054198 ClinicalTrials
Neoplasms 4 D009369 ClinicalTrials
Precursor Cell Lymphoblastic Leukemia-Lymphoma 4 D054198 ClinicalTrials
Precursor Cell Lymphoblastic Leukemia-Lymphoma 4 D054198 ClinicalTrials
Polymyalgia Rheumatica 3 D011111 ClinicalTrials
Lung Diseases 3 D008171 ClinicalTrials
Glomerulonephritis, Membranoproliferative 3 D015432 ClinicalTrials
Pemphigoid, Bullous 3 D010391 ClinicalTrials
Lymphoma, B-Cell, Marginal Zone 3 D018442 ClinicalTrials
Immune System Diseases 3 D007154 ClinicalTrials
Hodgkin Disease 3 D006689 ClinicalTrials
Multiple Sclerosis 3 D009103 ClinicalTrials
Waldenstrom Macroglobulinemia 3 D008258 ClinicalTrials
Waldenstrom Macroglobulinemia 3 D008258 ClinicalTrials
Polyneuropathies 3 D011115 ClinicalTrials
Polyradiculoneuropathy, Chronic Inflammatory Demyelinating 3 D020277 ClinicalTrials
Burkitt Lymphoma 3 D002051 ClinicalTrials
Lymphoma, Large B-Cell, Diffuse 3 D016403 ClinicalTrials
IgA Vasculitis 3 D011695 ClinicalTrials
Kidney Diseases 3 D007674 ClinicalTrials
Lymphoma, Follicular 3 D008224 ClinicalTrials
Myasthenia Gravis 3 D009157 ClinicalTrials
Polyradiculoneuropathy, Chronic Inflammatory Demyelinating 3 D020277 ClinicalTrials
Purpura, Thrombotic Thrombocytopenic 3 D011697 ClinicalTrials
Mental Disorders 3 D001523 ClinicalTrials
Lymphoma 3 D008223 ClinicalTrials
Graft vs Host Disease 3 D006086 ClinicalTrials
Glomerulonephritis, Membranous 3 D015433 ClinicalTrials
Hodgkin Disease 3 D006689 ClinicalTrials
Lymphoma, Follicular 3 D008224 ClinicalTrials
Nephrotic Syndrome 3 D009404 ClinicalTrials
Anemia, Hemolytic, Autoimmune 3 D000744 ClinicalTrials
Leukemia 3 D007938 ClinicalTrials
Lymphoma, Mantle-Cell 3 D020522 ClinicalTrials
Lung Diseases, Interstitial 3 D017563 ClinicalTrials
Leukemia, Lymphoid 3 D007945 ClinicalTrials
Lupus Erythematosus, Systemic 3 D008180 ClinicalTrials
Lupus Nephritis 3 D008181 ClinicalTrials
Fatigue Syndrome, Chronic 3 D015673 ClinicalTrials
Multiple Sclerosis, Relapsing-Remitting 3 D020529 ClinicalTrials
Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis 3 D056648 ClinicalTrials
Graft vs Host Disease 3 D006086 ClinicalTrials
Lymphoma, B-Cell, Marginal Zone 3 D018442 ClinicalTrials
Purpura, Thrombocytopenic, Idiopathic 3 D016553 ClinicalTrials
Anemia, Hemolytic, Autoimmune 3 D000744 ClinicalTrials
Proteinuria 3 D011507 ClinicalTrials
Kidney Failure, Chronic 2 D007676 ClinicalTrials
Scleroderma, Systemic 2 D012595 ClinicalTrials
Melanoma 2 D008545 ClinicalTrials
Neuromyelitis Optica 2 D009471 ClinicalTrials
Sjogren's Syndrome 2 D012859 ClinicalTrials
Glomerulosclerosis, Focal Segmental 2 D005923 ClinicalTrials
Colitis, Ulcerative 2 D003093 ClinicalTrials
Behcet Syndrome 2 D001528 ClinicalTrials
Multiple Sclerosis, Chronic Progressive 2 D020528 ClinicalTrials
Peripheral Nervous System Diseases 2 D010523 ClinicalTrials
Graves Ophthalmopathy 2 D049970 ClinicalTrials
Myelodysplastic Syndromes 2 D009190 ClinicalTrials
Immunoblastic Lymphadenopathy 2 D007119 ClinicalTrials
Leukemia, Myelogenous, Chronic, BCR-ABL Positive 2 D015464 ClinicalTrials
Melanoma 2 D008545 ClinicalTrials
Dermatomyositis 2 D003882 ClinicalTrials
Idiopathic Pulmonary Fibrosis 2 D054990 ClinicalTrials
Pneumococcal Infections 2 D011008 ClinicalTrials
Multiple Myeloma 2 D009101 ClinicalTrials
Hematologic Neoplasms 2 D019337 ClinicalTrials
Lymphoma, Large-Cell, Anaplastic 2 D017728 ClinicalTrials
Heart Failure 2 D006333 ClinicalTrials
Pancreatic Neoplasms 2 D010190 ClinicalTrials
Breast Neoplasms 2 D001943 ClinicalTrials
Stomach Neoplasms 2 D013274 ClinicalTrials
Spondylitis, Ankylosing 2 D013167 ClinicalTrials
Colonic Neoplasms 2 D003110 ClinicalTrials
Churg-Strauss Syndrome 2 D015267 ClinicalTrials
Encephalitis, Japanese 2 D004672 ClinicalTrials
Leukemia, Mast-Cell 2 D007946 ClinicalTrials
Stiff-Person Syndrome 2 D016750 ClinicalTrials
Diabetic Neuropathies 2 D003929 ClinicalTrials
Leukemia, Hairy Cell 2 D007943 ClinicalTrials
Lymphoma, AIDS-Related 2 D016483 ClinicalTrials
Leukemia, Biphenotypic, Acute 2 D015456 ClinicalTrials
Leukemia, Myeloid, Acute 2 D015470 ClinicalTrials
Acquired Immunodeficiency Syndrome 2 D000163 ClinicalTrials
Multiple Sclerosis, Chronic Progressive 2 D020528 ClinicalTrials
Multiple Sclerosis, Chronic Progressive 2 D020528 ClinicalTrials
Histiocytosis, Langerhans-Cell 2 D006646 ClinicalTrials
Leukemia, Myelomonocytic, Chronic 2 D015477 ClinicalTrials
Renal Insufficiency 2 D051437 ClinicalTrials
Anemia, Aplastic 2 D000741 ClinicalTrials
Blast Crisis 2 D001752 ClinicalTrials
Leukemia, Prolymphocytic 2 D015463 ClinicalTrials
Pulmonary Alveolar Proteinosis 2 D011649 ClinicalTrials
Hemolytic-Uremic Syndrome 2 D006463 ClinicalTrials
Glomerulonephritis 2 D005921 ClinicalTrials
Lung Neoplasms 2 D008175 ClinicalTrials
Hematologic Neoplasms 2 D019337 ClinicalTrials
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma 2 D054218 ClinicalTrials
Hematologic Neoplasms 2 D019337 ClinicalTrials
Leukemia, Biphenotypic, Acute 2 D015456 ClinicalTrials
HTLV-I Infections 2 D015490 ClinicalTrials
Spinal Cord Diseases 2 D013118 ClinicalTrials
Schizophrenia 2 D012559 ClinicalTrials
Diabetes Mellitus, Type 1 2 D003922 ClinicalTrials
Hemophilia A 2 D006467 ClinicalTrials
Anemia, Sickle Cell 2 D000755 ClinicalTrials
Lymphoproliferative Disorders 2 D008232 ClinicalTrials
Sarcoidosis 2 D012507 ClinicalTrials
Rheumatic Heart Disease 2 D012214 ClinicalTrials
Lymphoma, B-Cell 2 D016393 ClinicalTrials
Bronchiolitis Obliterans Syndrome 2 D000092122 ClinicalTrials
Carcinoma, Hepatocellular 2 D006528 ClinicalTrials
Neoplasms, Plasma Cell 2 D054219 ClinicalTrials
Melanoma 2 D008545 ClinicalTrials
Virus Diseases 2 D014777 ClinicalTrials
Psychotic Disorders 2 D011618 ClinicalTrials
Blastic Plasmacytoid Dendritic Cell Neoplasm 2 D000099067 ClinicalTrials
Polyendocrinopathies, Autoimmune 2 D016884 ClinicalTrials
Leukemia, Biphenotypic, Acute 2 D015456 ClinicalTrials
Castleman Disease 2 D005871 ClinicalTrials
Prostatic Neoplasms, Castration-Resistant 1 D064129 ClinicalTrials
Scleritis 1 D015423 ClinicalTrials
Renal Insufficiency, Chronic 1 D051436 ClinicalTrials
Hematologic Diseases 1 D006402 ClinicalTrials
Encephalomyelitis 1 D004679 ClinicalTrials
Fanconi Anemia 1 D005199 ClinicalTrials
Liver Cirrhosis, Biliary 1 D008105 ClinicalTrials
Opsoclonus-Myoclonus Syndrome 1 D053578 ClinicalTrials
Carcinoma, Squamous Cell 1 D002294 ClinicalTrials
Mycosis Fungoides 1 D009182 ClinicalTrials
Macular Degeneration 1 D008268 ClinicalTrials
Pemphigoid, Benign Mucous Membrane 1 D010390 ClinicalTrials
Lymphoma, Primary Effusion 1 D054685 ClinicalTrials
Lymphoma, T-Cell, Cutaneous 1 D016410 ClinicalTrials
Urticaria 1 D014581 ClinicalTrials
Autoimmune Diseases 1 D001327 ClinicalTrials
Arthritis, Psoriatic 1 D015535 ClinicalTrials
Graves Disease 1 D006111 ClinicalTrials
Muscular Diseases 1 D009135 ClinicalTrials
Gout 1 D006073 ClinicalTrials
Crohn Disease 1 D003424 ClinicalTrials
Neuroblastoma 1 D009447 ClinicalTrials
Gangliosidoses 1 D005733 ClinicalTrials
Glycogen Storage Disease Type II 1 D006009 ClinicalTrials

Related Entries

Mixture

Adverse Reactions

SOC By Demographic Distribution
System Organ Classification (SOC)
Relative Frequency (%)
General disorders and administration site conditions
12.32
Infections and infestations
8.75
Respiratory, thoracic and mediastinal disorders
8.52
Musculoskeletal and connective tissue disorders
7.91
Gastrointestinal disorders
6.73
Nervous system disorders
6.52
Injury, poisoning and procedural complications
6.11
Investigations
5.79
Skin and subcutaneous tissue disorders
5.31
Vascular disorders
5.29
Immune system disorders
4.63
Blood and lymphatic system disorders
4.04
Cardiac disorders
3.71
Neoplasms benign, malignant and unspecified (incl cysts and polyps)
2.65
Psychiatric disorders
2.3
Renal and urinary disorders
2.2
Metabolism and nutrition disorders
2.17

Cross References

Resources Reference
CAS NUMBER 174722-31-7
ChEMBL CHEMBL1201576
FDA SRS 4F4X42SYQ6
Guide to Pharmacology 6780
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