Trade Names:
Synonyms:
Status: Approved (2015)
Entry Type: Antibody
Molecule Category: UNKNOWN
ATC: L04AC10
UNII: DLG4EML025

Pharmacology

Action Mechanism of Action Reference
INHIBITOR Interleukin 17A inhibitor FDA

Indications

Mesh Heading Maximum Phase Mesh ID Reference
Spondylitis, Ankylosing 3 D013167 ClinicalTrials
Arthritis, Rheumatoid 3 D001172 ClinicalTrials
Behcet Syndrome 3 D001528 ClinicalTrials
Uveitis 3 D014605 ClinicalTrials
Osteoarthritis 3 D010003 ClinicalTrials
Hidradenitis Suppurativa 3 D017497 ClinicalTrials
Giant Cell Arteritis 3 D013700 ClinicalTrials
Lupus Nephritis 3 D008181 ClinicalTrials
Graves Ophthalmopathy 3 D049970 ClinicalTrials
Dermatitis, Atopic 2 D003876 ClinicalTrials
Dry Eye Syndromes 2 D015352 ClinicalTrials
Multiple Sclerosis 2 D009103 ClinicalTrials
Diabetes Mellitus, Type 1 2 D003922 ClinicalTrials
Pyoderma 2 D011711 ClinicalTrials
Lupus Erythematosus, Discoid 2 D008179 ClinicalTrials
Tendinopathy 2 D052256 ClinicalTrials
Polymyalgia Rheumatica 2 D011111 ClinicalTrials
Asthma 2 D001249 ClinicalTrials
Necrobiosis Lipoidica 2 D009335 ClinicalTrials
Alopecia Areata 2 D000506 ClinicalTrials
Crohn Disease 2 D003424 ClinicalTrials
Multiple Sclerosis, Relapsing-Remitting 2 D020529 ClinicalTrials
Pityriasis Rubra Pilaris 1 D010916 ClinicalTrials
Rosacea 1 D012393 ClinicalTrials

Adverse Reactions

System Organ Classification (SOC)
Relative Frequency (%)
General disorders and administration site conditions
15.92
Skin and subcutaneous tissue disorders
12.6
Musculoskeletal and connective tissue disorders
9.19
Infections and infestations
8.81
Respiratory, thoracic and mediastinal disorders
8.58
Injury, poisoning and procedural complications
6.77
Gastrointestinal disorders
6.54
Immune system disorders
5.92
Nervous system disorders
5.59
Vascular disorders
3.32
Investigations
3.17
Psychiatric disorders
2.87
Cardiac disorders
2.5

Cross References

Resources Reference
CAS NUMBER 1229022-83-6
ChEMBL CHEMBL1743068
FDA SRS DLG4EML025
Guide to Pharmacology 8078