STREPTOZOCIN

Search structure


Trade Names:	ZANOSAR
Synonyms:	NSC-37917 NSC-85998 Streptozocin Streptozotocin STZ U-9889 Zanosar
Status:	Approved (1982)
Entry Type:	Small molecule
Molecule Category:	UNKNOWN
ATC:	L01AD04
UNII:	5W494URQ81

Structure


InChI Key	ZSJLQEPLLKMAKR-YDEIVXIUSA-N
Smile	CN(N=O)C(=O)N[C@H]1C(O)O[C@H](CO)[C@@H](O)[C@@H]1O
InChI	InChI=1S/C8H15N3O7/c1-11(10-17)8(16)9-4-6(14)5(13)3(2-12)18-7(4)15/h3-7,12-15H,2H2,1H3,(H,9,16)/t3-,4-,5-,6-,7?/m1/s1

Physicochemical Descriptors

Property Name	Value
Molecular Formula	C8H15N3O7
Molecular Weight	265.22
AlogP	-2.89
Hydrogen Bond Acceptor	8.0
Hydrogen Bond Donor	5.0
Number of Rotational Bond	3.0
Polar Surface Area	151.92
Molecular species	NEUTRAL
Aromatic Rings	0.0
Heavy Atoms	18.0

Experimental and Estimated Properties

Property Name	Value	Unit	Method
log P (octanol-water)	-1.45E+00	-	EXP
Henry's Law Constant	7.85E-22	atm-m3/mole	EST
Atmospheric OH Rate Constant	1.08E-10	cm3/molecule-sec	EST
Melting Point	115	deg C	EXP
Water Solubility	5070	mg/L	EST
Vapor Pressure	1.74E-12	mm Hg	EST

Pharmacology

Action	Mechanism of Action	Reference
INHIBITOR	DNA inhibitor	DailyMed Wikipedia

Indications

Mesh Heading	Maximum Phase	Mesh ID	Reference
Neuroendocrine Tumors	3	D018358	ClinicalTrials
Carcinoma	3	D002277	ClinicalTrials
Oligodendroglioma	2	D009837	ClinicalTrials
Pancreatic Neoplasms	2	D010190	ClinicalTrials
Glioma	2	D005910	ClinicalTrials
Brain Neoplasms	2	D001932	ClinicalTrials
Glioblastoma	2	D005909	ClinicalTrials
Astrocytoma	2	D001254	ClinicalTrials
Colorectal Neoplasms	1	D015179	ClinicalTrials

Adverse Reactions

SOC By Demographic Distribution

System Organ Classification (SOC)

	Relative Frequency (%)
Investigations	100.0

Cross References

Resources	Reference
CAS NUMBER	18883-66-4
ChEMBL	CHEMBL1651906
DrugCentral	2483
EPA CompTox	DTXSID90369855
FDA SRS	5W494URQ81
PubChem	23615975
SureChEMBL	SCHEMBL444088

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