SULFISOXAZOLE

Search structure
Trade Names:
Synonyms:
Status: Approved (1971)
Entry Type: Small molecule
Molecule Category: Parent
UNII: 740T4C525W

Structure
InChI Key NHUHCSRWZMLRLA-UHFFFAOYSA-N
Smile Cc1noc(NS(=O)(=O)c2ccc(N)cc2)c1C
InChI
InChI=1S/C11H13N3O3S/c1-7-8(2)13-17-11(7)14-18(15,16)10-5-3-9(12)4-6-10/h3-6,14H,12H2,1-2H3

Physicochemical Descriptors

Property Name Value
Molecular Formula C11H13N3O3S
Molecular Weight 267.31
AlogP 1.67
Hydrogen Bond Acceptor 5.0
Hydrogen Bond Donor 2.0
Number of Rotational Bond 3.0
Polar Surface Area 98.22
Molecular species ACID
Aromatic Rings 2.0
Heavy Atoms 18.0

Pharmacology

Action Mechanism of Action Reference
INHIBITOR Bacterial dihydropteroate synthase inhibitor PubMed
Targets EC50(nM) IC50(nM) Kd(nM) Ki(nM) Inhibition(%)
Membrane receptor Family A G protein-coupled receptor Peptide receptor (family A GPCR) Short peptide receptor (family A GPCR) Endothelin receptor
- 780-850 - - -
Transporter Electrochemical transporter SLC superfamily of solute carriers SLC21/SLCO family of organic anion transporting polypeptides
- - - - 79

Indications

Mesh Heading Maximum Phase Mesh ID Reference
Osteomyelitis 0 D010019 ClinicalTrials

Related Entries

Scaffolds

Salt
Mixture

Adverse Reactions

SOC By Demographic Distribution
System Organ Classification (SOC)
Relative Frequency (%)
Skin and subcutaneous tissue disorders
50.0
General disorders and administration site conditions
20.0
Blood and lymphatic system disorders
10.0
Immune system disorders
10.0
Injury, poisoning and procedural complications
10.0

Cross References

Resources Reference
CAS NUMBER 127-69-5
ChEBI 102484
ChEMBL CHEMBL453
DrugBank DB00263
DrugCentral 2529
EPA CompTox DTXSID6021292
FDA SRS 740T4C525W
Human Metabolome Database HMDB0014408
KEGG C07318
PharmGKB PA164748964
PubChem 5344
SureChEMBL SCHEMBL23467
ZINC ZINC000096006009
CONTENTS