| Trade Names: | |
| Synonyms: | |
| Status: | Approved (2019) |
| Entry Type: | Small molecule |
| Molecule Category: | UNKNOWN |
| ATC: | N07XX08 |
| UNII: | 8FG9H9D31J |
Structure
| InChI Key | TXEIIPDJKFWEEC-UHFFFAOYSA-N |
|---|---|
| Smile | |
| InChI |
|
Physicochemical Descriptors
| Property Name | Value |
|---|---|
| Molecular Formula | C14H7Cl2NO3 |
| Molecular Weight | 308.12 |
| AlogP | 4.5 |
| Hydrogen Bond Acceptor | 3.0 |
| Hydrogen Bond Donor | 1.0 |
| Number of Rotational Bond | 2.0 |
| Polar Surface Area | 63.33 |
| Molecular species | ACID |
| Aromatic Rings | 3.0 |
| Heavy Atoms | 20.0 |
Pharmacology
| Action | Mechanism of Action | Reference |
|---|---|---|
| STABILISER | Transthyretin stabiliser | PubMed |
| Targets | EC50(nM) | IC50(nM) | Kd(nM) | Ki(nM) | Inhibition(%) | |
|---|---|---|---|---|---|---|
|
Secreted protein
|
- | 1550-3100 | 3-2800 | - | 99 |
Indications
| Mesh Heading | Maximum Phase | Mesh ID | Reference |
|---|---|---|---|
| Cardiomyopathies | 4 | D009202 | ClinicalTrials |
| Amyloidosis, Familial | 4 | D028226 | FDA |
| Amyloid Neuropathies, Familial | 3 | D028227 | ClinicalTrials |
Related Entries
MCS
Scaffolds
Adverse Reactions
System Organ Classification (SOC)
Cross References
| Resources | Reference |
|---|---|
| CAS NUMBER | 594839-88-0 |
| ChEBI | 78538 |
| ChEMBL | CHEMBL2103837 |
| DrugBank | DB11644 |
| DrugCentral | 4192 |
| EPA CompTox | DTXSID00208185 |
| FDA SRS | 8FG9H9D31J |
| Guide to Pharmacology | 8378 |
| PDB | 3MI |
| PubChem | 11001318 |
| SureChEMBL | SCHEMBL442508 |
| ZINC | ZINC000043206271 |
CONTENTS