TASIMELTEON

Search structure
Trade Names:
Synonyms:
Status: Approved (2014)
Entry Type: Small molecule
Molecule Category: UNKNOWN
ATC: N05CH03
UNII: SHS4PU80D9

Structure
InChI Key PTOIAAWZLUQTIO-GXFFZTMASA-N
Smile CCC(=O)NC[C@@H]1C[C@H]1c1cccc2c1CCO2
InChI
InChI=1S/C15H19NO2/c1-2-15(17)16-9-10-8-13(10)11-4-3-5-14-12(11)6-7-18-14/h3-5,10,13H,2,6-9H2,1H3,(H,16,17)/t10-,13+/m0/s1

Physicochemical Descriptors

Property Name Value
Molecular Formula C15H19NO2
Molecular Weight 245.32
AlogP 2.25
Hydrogen Bond Acceptor 2.0
Hydrogen Bond Donor 1.0
Number of Rotational Bond 4.0
Polar Surface Area 38.33
Molecular species NEUTRAL
Aromatic Rings 1.0
Heavy Atoms 18.0

Pharmacology

Action Mechanism of Action Reference
AGONIST Melatonin receptor agonist FDA
Primary Target
MT1 receptor
MT2 receptor

Indications

Mesh Heading Maximum Phase Mesh ID Reference
Sleep Wake Disorders 4 D012893 ClinicalTrials
Smith-Magenis Syndrome 4 D058496 ClinicalTrials
Sleep Initiation and Maintenance Disorders 3 D007319 ClinicalTrials
Depressive Disorder, Major 2 D003865 ClinicalTrials
Sleep Disorders, Circadian Rhythm 2 D020178 ClinicalTrials
Kidney Diseases 1 D007674 ClinicalTrials
Liver Diseases 1 D008107 ClinicalTrials

Side Effects from Label

Adverse Reactions

SOC By Demographic Distribution
System Organ Classification (SOC)
Relative Frequency (%)
Nervous system disorders
22.74
Psychiatric disorders
22.3
General disorders and administration site conditions
20.52
Injury, poisoning and procedural complications
5.49
Gastrointestinal disorders
5.1
Respiratory, thoracic and mediastinal disorders
4.2
Infections and infestations
2.87
Vascular disorders
2.27
Cardiac disorders
2.23
Musculoskeletal and connective tissue disorders
2.11

Cross References

Resources Reference
CAS NUMBER 609799-22-6
ChEBI 79042
ChEMBL CHEMBL2103822
DrugBank DB09071
DrugCentral 4820
EPA CompTox DTXSID70209826
FDA SRS SHS4PU80D9
Guide to Pharmacology 7393
PubChem 10220503
SureChEMBL SCHEMBL3505912
ZINC ZINC000004392649
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