TERBINAFINE HYDROCHLORIDE

Search structure
Trade Names:
Synonyms:
Status: Approved (1992)
Entry Type: Small molecule
Molecule Category: Salt
UNII: 012C11ZU6G
Parent Compound: TERBINAFINE

Structure
InChI Key BWMISRWJRUSYEX-SZKNIZGXSA-N
Smile CN(C/C=C/C#CC(C)(C)C)Cc1cccc2ccccc12.Cl
InChI
InChI=1S/C21H25N.ClH/c1-21(2,3)15-8-5-9-16-22(4)17-19-13-10-12-18-11-6-7-14-20(18)19;/h5-7,9-14H,16-17H2,1-4H3;1H/b9-5+;

Physicochemical Descriptors

Property Name Value
Molecular Formula C21H26ClN
Molecular Weight 327.9
AlogP 4.88
Hydrogen Bond Acceptor 1.0
Hydrogen Bond Donor 0.0
Number of Rotational Bond 4.0
Polar Surface Area 3.24
Molecular species BASE
Aromatic Rings 2.0
Heavy Atoms 22.0

Pharmacology

Action Mechanism of Action Reference
INHIBITOR Squalene monooxygenase inhibitor FDA

Indications

Mesh Heading Maximum Phase Mesh ID Reference
Tinea Pedis 3 D014008 ClinicalTrials

Related Entries

Scaffolds

Parent

Adverse Reactions

SOC By Demographic Distribution
System Organ Classification (SOC)
Relative Frequency (%)
Skin and subcutaneous tissue disorders
16.49
General disorders and administration site conditions
14.2
Nervous system disorders
9.65
Gastrointestinal disorders
8.86
Injury, poisoning and procedural complications
8.51
Immune system disorders
5.23
Musculoskeletal and connective tissue disorders
4.45
Psychiatric disorders
4.34
Investigations
4.0
Infections and infestations
3.99
Vascular disorders
2.63
Cardiac disorders
2.58
Respiratory, thoracic and mediastinal disorders
2.48
Hepatobiliary disorders
2.25
Blood and lymphatic system disorders
2.22
Metabolism and nutrition disorders
2.09

Cross References

Resources Reference
ChEBI 77614
ChEMBL CHEMBL1200832
EPA CompTox DTXSID90229223
FDA SRS 012C11ZU6G
KEGG C08079
PubChem 5282481
SureChEMBL SCHEMBL36793
ZINC ZINC01530981
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