TESTOSTERONE PROPIONATE

Search structure
Trade Names:
Synonyms:
Status: Approved (1974)
Entry Type: Small molecule
Molecule Category: UNKNOWN Prodrug
UNII: WI93Z9138A
Parent Compound: TESTOSTERONE

Structure
InChI Key PDMMFKSKQVNJMI-BLQWBTBKSA-N
Smile CCC(=O)O[C@H]1CC[C@H]2[C@@H]3CCC4=CC(=O)CC[C@]4(C)[C@H]3CC[C@]12C
InChI
InChI=1S/C22H32O3/c1-4-20(24)25-19-8-7-17-16-6-5-14-13-15(23)9-11-21(14,2)18(16)10-12-22(17,19)3/h13,16-19H,4-12H2,1-3H3/t16-,17-,18-,19-,21-,22-/m0/s1

Physicochemical Descriptors

Property Name Value
Molecular Formula C22H32O3
Molecular Weight 344.5
AlogP 4.84
Hydrogen Bond Acceptor 3.0
Hydrogen Bond Donor 0.0
Number of Rotational Bond 2.0
Polar Surface Area 43.37
Molecular species NEUTRAL
Aromatic Rings 0.0
Heavy Atoms 25.0

Pharmacology

Action Mechanism of Action Reference
AGONIST Androgen Receptor agonist PubMed PubMed PubMed PubMed PubMed PubMed
Primary Target
Androgen receptor
Targets EC50(nM) IC50(nM) Kd(nM) Ki(nM) Inhibition(%)
Enzyme Cytochrome P450 Cytochrome P450 family 17 Cytochrome P450 family 17A Cytochrome P450 17A1
- 56 - - -
Transcription factor Nuclear receptor Nuclear hormone receptor subfamily 3 Nuclear hormone receptor subfamily 3 group C Nuclear hormone receptor subfamily 3 group C member 4
3 18 - 0 -
Transporter Electrochemical transporter SLC superfamily of solute carriers SLC21/SLCO family of organic anion transporting polypeptides
- - - - 121

Indications

Mesh Heading Maximum Phase Mesh ID Reference
Atrophic Vaginitis 1 D059268 ClinicalTrials

Related Entries

Scaffolds

Parent

Adverse Reactions

SOC By Demographic Distribution
System Organ Classification (SOC)
Relative Frequency (%)
General disorders and administration site conditions
18.02
Injury, poisoning and procedural complications
16.86
Product issues
10.47
Psychiatric disorders
8.72
Cardiac disorders
6.98
Nervous system disorders
5.81
Vascular disorders
4.65
Gastrointestinal disorders
4.07
Investigations
3.49
Metabolism and nutrition disorders
3.49
Respiratory, thoracic and mediastinal disorders
3.49
Reproductive system and breast disorders
2.91
Skin and subcutaneous tissue disorders
2.91
Immune system disorders
2.33

Cross References

Resources Reference
CAS NUMBER 57-85-2
ChEBI 9466
ChEMBL CHEMBL1170
DrugBank DB01420
DrugCentral 4146
EPA CompTox DTXSID9036515
FDA SRS WI93Z9138A
Human Metabolome Database HMDB0015489
Guide to Pharmacology 7100
KEGG C08158
PharmGKB PA164751373
PubChem 5995
SureChEMBL SCHEMBL4044
ZINC ZINC000000490791
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