TETRACAINE HYDROCHLORIDE

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Trade Names:	TETRACAINE HYDROCHLORIDE
Synonyms:	Amethocaine hydrochloride Anethaine Butethanol Curtacain Dicainum Locan Menonasal NSC-757337 Pantocaine Pontocaine hydrochloride Tetocaine Tetraca Tetracaine hcl Tetracaine hydrochloride Tetracaini hydrochloridum
Status:	Approved (2016)
Entry Type:	Small molecule
Molecule Category:	Salt
UNII:	5NF5D4OPCI
Parent Compound:	TETRACAINE

Structure


InChI Key	PPWHTZKZQNXVAE-UHFFFAOYSA-N
Smile	CCCCNc1ccc(C(=O)OCCN(C)C)cc1.Cl
InChI	InChI=1S/C15H24N2O2.ClH/c1-4-5-10-16-14-8-6-13(7-9-14)15(18)19-12-11-17(2)3;/h6-9,16H,4-5,10-12H2,1-3H3;1H

Physicochemical Descriptors

Property Name	Value
Molecular Formula	C15H25ClN2O2
Molecular Weight	300.83
AlogP	2.62
Hydrogen Bond Acceptor	4.0
Hydrogen Bond Donor	1.0
Number of Rotational Bond	8.0
Polar Surface Area	41.57
Molecular species	NEUTRAL
Aromatic Rings	1.0
Heavy Atoms	19.0

Pharmacology

Action	Mechanism of Action	Reference
BLOCKER	Sodium channel alpha subunit blocker	ISBN PubMed PubMed PubMed

Targets	EC50(nM)	IC50(nM)	Kd(nM)	Ki(nM)	Inhibition(%)
Transporter Electrochemical transporter SLC superfamily of solute carriers SLC21/SLCO family of organic anion transporting polypeptides	-	-	-	-	62

Indications

Mesh Heading	Maximum Phase	Mesh ID	Reference

Related Entries

Parent

Mixture

Adverse Reactions

SOC By Demographic Distribution

System Organ Classification (SOC)

	Relative Frequency (%)
Eye disorders	80.0
General disorders and administration site conditions	20.0

Cross References

Resources	Reference
ChEBI	9469
ChEMBL	CHEMBL1255654
EPA CompTox	DTXSID6042448
FDA SRS	5NF5D4OPCI
PubChem	8695
SureChEMBL	SCHEMBL24370

CONTENTS