TRASTUZUMAB

Search structure
Trade Names:
Synonyms:
Status: Approved (1998)
Entry Type: Antibody
Molecule Category: Parent
ATC: L01XC03
UNII: P188ANX8CK

Pharmacology

Action Mechanism of Action Reference
INHIBITOR Receptor protein-tyrosine kinase erbB-2 inhibitor DailyMed

Indications

Mesh Heading Maximum Phase Mesh ID Reference
Neoplasms 4 D009369 ClinicalTrials
Breast Neoplasms 4 D001943 ClinicalTrials
Neoplasms 4 D009369 ClinicalTrials
Inflammatory Breast Neoplasms 3 D058922 ClinicalTrials
Stomach Neoplasms 3 D013274 ClinicalTrials
Stomach Neoplasms 3 D013274 ClinicalTrials
Brain Diseases 3 D001927 ClinicalTrials
Carcinoma, Intraductal, Noninfiltrating 3 D002285 ClinicalTrials
Breast Neoplasms, Male 3 D018567 ClinicalTrials
Stomach Neoplasms 3 D013274 ClinicalTrials
Pancreatic Neoplasms 2 D010190 ClinicalTrials
Carcinoma 2 D002277 ClinicalTrials
Carcinoma, Non-Small-Cell Lung 2 D002289 ClinicalTrials
Leukemia, Myeloid, Acute 2 D015470 ClinicalTrials
Urinary Bladder Neoplasms 2 D001749 ClinicalTrials
Leukemia 2 D007938 ClinicalTrials
Osteosarcoma 2 D012516 ClinicalTrials
Sarcoma 2 D012509 ClinicalTrials
Adenocarcinoma 2 D000230 ClinicalTrials
Urogenital Neoplasms 2 D014565 ClinicalTrials
Head and Neck Neoplasms 2 D006258 ClinicalTrials
Endometrial Neoplasms 2 D016889 ClinicalTrials
Colorectal Neoplasms 2 D015179 ClinicalTrials
Ovarian Neoplasms 2 D010051 ClinicalTrials
Neoplasm Metastasis 2 D009362 ClinicalTrials
Hemangiosarcoma 2 D006394 ClinicalTrials
Cholangiocarcinoma 2 D018281 ClinicalTrials
Carcinoma, Ductal 2 D044584 ClinicalTrials
Urinary Bladder Neoplasms 2 D001749 ClinicalTrials
Urethral Neoplasms 2 D014523 ClinicalTrials
Salivary Gland Neoplasms 2 D012468 ClinicalTrials
Ovarian Neoplasms 2 D010051 ClinicalTrials
Prostatic Neoplasms, Castration-Resistant 2 D064129 ClinicalTrials
Lung Neoplasms 2 D008175 ClinicalTrials
Endometrial Neoplasms 2 D016889 ClinicalTrials
Biliary Tract Neoplasms 2 D001661 ClinicalTrials
Digestive System Neoplasms 2 D004067 ClinicalTrials
Osteitis Deformans 2 D010001 ClinicalTrials
Oropharyngeal Neoplasms 1 D009959 ClinicalTrials
Pericardial Effusion 1 D010490 ClinicalTrials
Vaginal Neoplasms 1 D014625 ClinicalTrials
Vulvar Neoplasms 1 D014846 ClinicalTrials
Anus Neoplasms 1 D001005 ClinicalTrials
Peritoneal Neoplasms 1 D010534 ClinicalTrials
Fallopian Tube Neoplasms 1 D005185 ClinicalTrials
Uterine Cervical Neoplasms 1 D002583 ClinicalTrials
Appendiceal Neoplasms 1 D001063 ClinicalTrials
Lymphoma, Non-Hodgkin 1 D008228 ClinicalTrials
Ependymoma 1 D004806 ClinicalTrials
Esophageal Neoplasms 1 D004938 ClinicalTrials
Somatostatinoma 1 D013005 ClinicalTrials
Testicular Neoplasms 1 D013736 ClinicalTrials
Squamous Cell Carcinoma of Head and Neck 1 D000077195 ClinicalTrials
Skin Diseases 1 D012871 ClinicalTrials
Hodgkin Disease 1 D006689 ClinicalTrials
Pleural Effusion 1 D010996 ClinicalTrials
Gallbladder Neoplasms 1 D005706 ClinicalTrials
Adrenal Cortex Neoplasms 1 D000306 ClinicalTrials
Mycosis Fungoides 1 D009182 ClinicalTrials
Thyroid Neoplasms 1 D013964 ClinicalTrials
Adenocarcinoma, Follicular 1 D018263 ClinicalTrials
Esophageal Neoplasms 1 D004938 ClinicalTrials
Parathyroid Neoplasms 1 D010282 ClinicalTrials
Insulinoma 1 D007340 ClinicalTrials

Related Entries

Mixture

Adverse Reactions

SOC By Demographic Distribution
System Organ Classification (SOC)
Relative Frequency (%)
General disorders and administration site conditions
15.06
Gastrointestinal disorders
10.11
Nervous system disorders
8.04
Respiratory, thoracic and mediastinal disorders
7.77
Cardiac disorders
6.63
Skin and subcutaneous tissue disorders
6.45
Investigations
5.59
Vascular disorders
5.26
Musculoskeletal and connective tissue disorders
4.79
Blood and lymphatic system disorders
4.47
Infections and infestations
4.43
Neoplasms benign, malignant and unspecified (incl cysts and polyps)
3.98
Injury, poisoning and procedural complications
3.85
Metabolism and nutrition disorders
3.15
Psychiatric disorders
2.05

Cross References

Resources Reference
CAS NUMBER 180288-69-1
ChEMBL CHEMBL1201585
FDA SRS P188ANX8CK
Guide to Pharmacology 5082
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