| Trade Names: | |
| Synonyms: | |
| Status: | Approved (1960) |
| Entry Type: | Small molecule |
| Molecule Category: | Parent |
| UNII: | F446C597KA |
Structure
| InChI Key | YNDXUCZADRHECN-JNQJZLCISA-N |
|---|---|
| Smile | |
| InChI |
|
Physicochemical Descriptors
| Property Name | Value |
|---|---|
| Molecular Formula | C24H31FO6 |
| Molecular Weight | 434.5 |
| AlogP | 2.42 |
| Hydrogen Bond Acceptor | 6.0 |
| Hydrogen Bond Donor | 2.0 |
| Number of Rotational Bond | 2.0 |
| Polar Surface Area | 93.06 |
| Molecular species | NEUTRAL |
| Aromatic Rings | 0.0 |
| Heavy Atoms | 31.0 |
Pharmacology
| Targets | EC50(nM) | IC50(nM) | Kd(nM) | Ki(nM) | Inhibition(%) | |
|---|---|---|---|---|---|---|
|
Transporter
Electrochemical transporter
SLC superfamily of solute carriers
SLC21/SLCO family of organic anion transporting polypeptides
|
- | - | - | - | 116 |
Indications
| Mesh Heading | Maximum Phase | Mesh ID | Reference |
|---|---|---|---|
| Tennis Elbow | 4 | D013716 | ClinicalTrials |
| Asthma | 4 | D001249 | ClinicalTrials |
| Rhinitis, Allergic, Seasonal | 4 | D006255 | ClinicalTrials |
| Gout | 4 | D006073 | ClinicalTrials |
| Bursitis | 4 | D002062 | ClinicalTrials |
| Eye Injuries | 3 | D005131 | ClinicalTrials |
| Osteoarthritis, Knee | 3 | D020370 | ClinicalTrials |
| Dupuytren Contracture | 3 | D004387 | ClinicalTrials |
| Retinal Vein Occlusion | 3 | D012170 | ClinicalTrials |
| Uveitis | 3 | D014605 | ClinicalTrials |
| Optic Neuropathy, Ischemic | 3 | D018917 | ClinicalTrials |
| Macular Degeneration | 3 | D008268 | ClinicalTrials |
| Wet Macular Degeneration | 3 | D057135 | ClinicalTrials |
| Pemphigus | 3 | D010392 | ClinicalTrials |
| Chalazion | 3 | D017043 | ClinicalTrials |
| Vitreoretinopathy, Proliferative | 3 | D018630 | ClinicalTrials |
| Cystitis, Interstitial | 3 | D018856 | ClinicalTrials |
| Lichen Planus, Oral | 3 | D017676 | ClinicalTrials |
| Rhinitis | 3 | D012220 | ClinicalTrials |
| Macular Degeneration | 3 | D008268 | ClinicalTrials |
| Osteoarthritis, Hip | 3 | D015207 | ClinicalTrials |
| Radiculopathy | 3 | D011843 | ClinicalTrials |
| Macular Edema | 3 | D008269 | ClinicalTrials |
| Tendinopathy | 3 | D052256 | ClinicalTrials |
| Otitis Media with Effusion | 3 | D010034 | ClinicalTrials |
| Cough | 3 | D003371 | ClinicalTrials |
| Pemphigoid, Benign Mucous Membrane | 2 | D010390 | ClinicalTrials |
| Hand Dermatoses | 2 | D006229 | ClinicalTrials |
| Glaucoma | 2 | D005901 | ClinicalTrials |
| Keloid | 2 | D007627 | ClinicalTrials |
| Cataract | 2 | D002386 | ClinicalTrials |
| Dermatitis, Atopic | 2 | D003876 | ClinicalTrials |
| Shoulder Pain | 2 | D020069 | ClinicalTrials |
| Diabetic Retinopathy | 2 | D003930 | ClinicalTrials |
| Alopecia Areata | 2 | D000506 | ClinicalTrials |
| Vitiligo | 2 | D014820 | ClinicalTrials |
| Lichen Planus | 2 | D008010 | ClinicalTrials |
| Mucositis | 1 | D052016 | ClinicalTrials |
| Fibroma | 1 | D005350 | ClinicalTrials |
| Neurilemmoma | 1 | D009442 | ClinicalTrials |
| Rotator Cuff Injuries | 1 | D000070636 | ClinicalTrials |
| Hearing Loss | 1 | D034381 | ClinicalTrials |
| Humeral Fractures | 0 | D006810 | ClinicalTrials |
| Papilledema | 0 | D010211 | ClinicalTrials |
| Tendon Entrapment | 0 | D053682 | ClinicalTrials |
Related Entries
Adverse Reactions
System Organ Classification (SOC)
Cross References
| Resources | Reference |
|---|---|
| ChEBI | 71418 |
| ChEMBL | CHEMBL1504 |
| DrugCentral | 2726 |
| EPA CompTox | DTXSID6021371 |
| FDA SRS | F446C597KA |
| Guide to Pharmacology | 2867 |
| KEGG | C08183 |
| PDB | 1TA |
| PubChem | 6436 |
| SureChEMBL | SCHEMBL4689 |
| ZINC | ZINC000003875481 |
CONTENTS