TRIAMCINOLONE HEXACETONIDE

Search structure
Trade Names:
Synonyms:
Status: Approved (1969)
Entry Type: Small molecule
Molecule Category: UNKNOWN Prodrug
UNII: I7GT1U99Y9

Structure
InChI Key TZIZWYVVGLXXFV-FLRHRWPCSA-N
Smile CC(C)(C)CC(=O)OCC(=O)[C@@]12OC(C)(C)O[C@@H]1C[C@H]1[C@@H]3CCC4=CC(=O)C=C[C@]4(C)[C@@]3(F)[C@@H](O)C[C@@]12C
InChI
InChI=1S/C30H41FO7/c1-25(2,3)15-24(35)36-16-22(34)30-23(37-26(4,5)38-30)13-20-19-9-8-17-12-18(32)10-11-27(17,6)29(19,31)21(33)14-28(20,30)7/h10-12,19-21,23,33H,8-9,13-16H2,1-7H3/t19-,20-,21-,23+,27-,28-,29-,30+/m0/s1

Physicochemical Descriptors

Property Name Value
Molecular Formula C30H41FO7
Molecular Weight 532.65
AlogP 4.41
Hydrogen Bond Acceptor 7.0
Hydrogen Bond Donor 1.0
Number of Rotational Bond 4.0
Polar Surface Area 99.13
Molecular species NEUTRAL
Aromatic Rings 0.0
Heavy Atoms 38.0

Pharmacology

Action Mechanism of Action Reference
AGONIST Glucocorticoid receptor agonist DailyMed Wikipedia

Indications

Mesh Heading Maximum Phase Mesh ID Reference
Osteoarthritis 4 D010003 ClinicalTrials
Arthritis, Rheumatoid 2 D001172 ClinicalTrials
Pain 2 D010146 ClinicalTrials

Related Entries

MCS

Scaffolds

Adverse Reactions

SOC By Demographic Distribution
System Organ Classification (SOC)
Relative Frequency (%)
Skin and subcutaneous tissue disorders
11.12
General disorders and administration site conditions
10.91
Nervous system disorders
9.18
Vascular disorders
9.07
Eye disorders
7.88
Musculoskeletal and connective tissue disorders
7.02
Metabolism and nutrition disorders
6.05
Infections and infestations
5.29
Psychiatric disorders
5.08
Endocrine disorders
4.86
Gastrointestinal disorders
4.54
Injury, poisoning and procedural complications
4.1
Immune system disorders
3.24
Cardiac disorders
3.02
Investigations
2.38
Respiratory, thoracic and mediastinal disorders
2.27

Cross References

Resources Reference
ChEBI 9670
ChEMBL CHEMBL1200878
DrugCentral 4976
EPA CompTox DTXSID0048634
FDA SRS I7GT1U99Y9
KEGG C08185
PubChem 21826
SureChEMBL SCHEMBL7543
ZINC ZINC000004097475
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