TRIMETHOPRIM HYDROCHLORIDE

Search structure
Trade Names:
Synonyms:
Status: Approved (1995)
Entry Type: Small molecule
Molecule Category: Salt
UNII: 9XE000OU9B
Parent Compound: TRIMETHOPRIM

Structure
InChI Key YLCCEQZHUHUYPA-UHFFFAOYSA-N
Smile COc1cc(Cc2cnc(N)nc2N)cc(OC)c1OC.Cl
InChI
InChI=1S/C14H18N4O3.ClH/c1-19-10-5-8(6-11(20-2)12(10)21-3)4-9-7-17-14(16)18-13(9)15;/h5-7H,4H2,1-3H3,(H4,15,16,17,18);1H

Physicochemical Descriptors

Property Name Value
Molecular Formula C14H19ClN4O3
Molecular Weight 326.78
AlogP 1.26
Hydrogen Bond Acceptor 7.0
Hydrogen Bond Donor 2.0
Number of Rotational Bond 5.0
Polar Surface Area 105.51
Molecular species NEUTRAL
Aromatic Rings 2.0
Heavy Atoms 21.0

Pharmacology

Action Mechanism of Action Reference
INHIBITOR Bacterial dihydrofolate reductase inhibitor DailyMed

Indications

Mesh Heading Maximum Phase Mesh ID Reference
Osteomyelitis 0 D010019 ClinicalTrials

Related Entries

Parent

Cross References

Resources Reference
ChEMBL CHEMBL1201080
EPA CompTox DTXSID40209671
FDA SRS 9XE000OU9B
PubChem 173769
SureChEMBL SCHEMBL1236697
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