TRIMIPRAMINE MALEATE

Search structure
Trade Names:
Synonyms:
Status: Approved (1979)
Entry Type: Small molecule
Molecule Category: UNKNOWN
UNII: I412286V22

Structure
InChI Key YDGHCKHAXOUQOS-BTJKTKAUSA-N
Smile CC(CN(C)C)CN1c2ccccc2CCc2ccccc21.O=C(O)/C=C\C(=O)O
InChI
InChI=1S/C20H26N2.C4H4O4/c1-16(14-21(2)3)15-22-19-10-6-4-8-17(19)12-13-18-9-5-7-11-20(18)22;5-3(6)1-2-4(7)8/h4-11,16H,12-15H2,1-3H3;1-2H,(H,5,6)(H,7,8)/b;2-1-

Physicochemical Descriptors

Property Name Value
Molecular Formula C24H30N2O4
Molecular Weight 410.51
AlogP 4.12
Hydrogen Bond Acceptor 2.0
Hydrogen Bond Donor 0.0
Number of Rotational Bond 4.0
Polar Surface Area 6.48
Molecular species BASE
Aromatic Rings 2.0
Heavy Atoms 22.0

Pharmacology

Action Mechanism of Action Reference
ANTAGONIST Adrenergic receptor alpha-1 antagonist ISBN PubMed Wikipedia
Targets EC50(nM) IC50(nM) Kd(nM) Ki(nM) Inhibition(%)
Transporter Electrochemical transporter SLC superfamily of solute carriers SLC21/SLCO family of organic anion transporting polypeptides
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Related Entries

MCS

Scaffolds

Adverse Reactions

SOC By Demographic Distribution
System Organ Classification (SOC)
Relative Frequency (%)
Nervous system disorders
19.34
Psychiatric disorders
18.78
General disorders and administration site conditions
11.05
Injury, poisoning and procedural complications
8.84
Cardiac disorders
6.63
Pregnancy, puerperium and perinatal conditions
4.97
Respiratory, thoracic and mediastinal disorders
4.42
Gastrointestinal disorders
3.31
Vascular disorders
3.31
Product issues
2.76
Blood and lymphatic system disorders
2.21
Renal and urinary disorders
2.21

Cross References

Resources Reference
ChEBI 35030
ChEMBL CHEMBL1200948
EPA CompTox DTXSID2045315
FDA SRS I412286V22
Guide to Pharmacology 7317
KEGG C14029
PubChem 5282318
SureChEMBL SCHEMBL41289
ZINC ZINC03831586
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