VANDETANIB

Search structure
Trade Names:
Synonyms:
Status: Approved (2011)
Entry Type: Small molecule
Molecule Category: UNKNOWN
ATC: L01EX04
UNII: YO460OQ37K

Structure
InChI Key UHTHHESEBZOYNR-UHFFFAOYSA-N
Smile COc1cc2c(Nc3ccc(Br)cc3F)ncnc2cc1OCC1CCN(C)CC1
InChI
InChI=1S/C22H24BrFN4O2/c1-28-7-5-14(6-8-28)12-30-21-11-19-16(10-20(21)29-2)22(26-13-25-19)27-18-4-3-15(23)9-17(18)24/h3-4,9-11,13-14H,5-8,12H2,1-2H3,(H,25,26,27)

Physicochemical Descriptors

Property Name Value
Molecular Formula C22H24BrFN4O2
Molecular Weight 475.36
AlogP 5.0
Hydrogen Bond Acceptor 6.0
Hydrogen Bond Donor 1.0
Number of Rotational Bond 6.0
Polar Surface Area 59.51
Molecular species BASE
Aromatic Rings 3.0
Heavy Atoms 30.0

Pharmacology

Action Mechanism of Action Reference
INHIBITOR Ephrin receptor inhibitor DailyMed
Primary Target
kinase insert domain receptor
ret proto-oncogene
Targets EC50(nM) IC50(nM) Kd(nM) Ki(nM) Inhibition(%)
Enzyme Kinase Protein Kinase AGC protein kinase group AGC protein kinase DMPK family AGC protein kinase CRIK subfamily
- - 1800-1800 - -
Enzyme Kinase Protein Kinase AGC protein kinase group AGC protein kinase DMPK family AGC protein kinase GEK subfamily
- - 2200-2200 - -
Enzyme Kinase Protein Kinase AGC protein kinase group AGC protein kinase DMPK family AGC protein kinase ROCK subfamily
- - 3600 - -
Enzyme Kinase Protein Kinase AGC protein kinase group AGC protein kinase RSK family AGC protein kinase p70 subfamily
- - 1600 - -
Enzyme Kinase Protein Kinase AGC protein kinase group AGC protein kinase RSK family AGC protein kinase RSK subfamily
- - 240-240 - -
Enzyme Kinase Protein Kinase AGC protein kinase group AGC protein kinase YANK family
- - 5000 - -
Enzyme Kinase Protein Kinase Atypical protein kinase group Atypical protein kinase ABC1 family Atypical protein kinase ABC1-A subfamily
- - 1700-1700 - -
Enzyme Kinase Protein Kinase Atypical protein kinase group
- - 1700-1700 - -
Enzyme Kinase Protein Kinase CAMK protein kinase group CAMK protein kinase CAMK1 family CAMK protein kinase AMPK subfamily
- - 3000-10000 - -
Enzyme Kinase Protein Kinase CAMK protein kinase group CAMK protein kinase CAMK1 family CAMK protein kinase QIK subfamily
- - 1900-1900 - -
Enzyme Kinase Protein Kinase CAMK protein kinase group CAMK protein kinase MAPKAPK family CAMK protein kinase MNK subfamily
- - 1700-3400 - -
Enzyme Kinase Protein Kinase CAMK protein kinase group CAMK protein kinase PHk family
- - 1100-7100 - -
Enzyme Kinase Protein Kinase CAMK protein kinase group CAMK protein kinase RSKb family CAMK protein kinase RSKb subfamily
- - 240-240 - -
Enzyme Kinase Protein Kinase CAMK protein kinase group CAMK protein kinase unique family
- - 1400-1400 - -
Enzyme Kinase Protein Kinase CAMK protein kinase group
- - 1100-7100 - -
Enzyme Kinase Protein Kinase CK1 protein kinase group CK1 protein kinase CK1 family
- - 1500-3000 - -
Enzyme Kinase Protein Kinase CMGC protein kinase group CMGC protein kinase CDK family CMGC protein kinase CDK7 subfamily
- - 4100 - -
Enzyme Kinase Protein Kinase CMGC protein kinase group CMGC protein kinase MAPK family CMGC protein kinase ERK3
- - 1500-1500 - -
Enzyme Kinase Protein Kinase Other protein kinase group Other protein kinase AUR family
- - 1500-1500 - -
Enzyme Kinase Protein Kinase Other protein kinase group Other protein kinase NAK family
- - 86-330 - -
Enzyme Kinase Protein Kinase Other protein kinase group Other protein kinase NKF4 family
- - 56 - -
Enzyme Kinase Protein Kinase Other protein kinase group Other protein kinase PLK family
- - 620-1500 - -
Enzyme Kinase Protein Kinase Other protein kinase group Other protein kinase ULK family
- - 6400 - -
Enzyme Kinase Protein Kinase STE protein kinase group STE protein kinase STE11 family
- - 3000-4800 - -
Enzyme Kinase Protein Kinase STE protein kinase group STE protein kinase STE20 family STE protein kinase KHS subfamily
- - 450-510 - -
Enzyme Kinase Protein Kinase STE protein kinase group STE protein kinase STE20 family STE protein kinase MSN subfamily
- - 2300-3900 - -
Enzyme Kinase Protein Kinase STE protein kinase group STE protein kinase STE20 family STE protein kinase SLK subfamily
- - 81-2400 - -
Enzyme Kinase Protein Kinase STE protein kinase group STE protein kinase STE7 family
- - 1100-1100 - -
Enzyme Kinase Protein Kinase TKL protein kinase group TKL protein kinase IRAK family
- - 1200 - -
Enzyme Kinase Protein Kinase TKL protein kinase group TKL protein kinase LISK family TKL protein kinase TESK subfamily
- - 3700-3700 - -
Enzyme Kinase Protein Kinase TKL protein kinase group TKL protein kinase MLK family TKL protein kinase HH498 subfamily
- - 2800-2800 - -
Enzyme Kinase Protein Kinase TKL protein kinase group TKL protein kinase MLK family TKL protein kinase MLK subfamily
- - 5100-5100 - -
Enzyme Kinase Protein Kinase TKL protein kinase group TKL protein kinase RIPK family
- - 5-31 - -
Enzyme Kinase Protein Kinase TKL protein kinase group TKL protein kinase STKR family TKL protein kinase STKR1
- - 150-150 - -
Enzyme Kinase Protein Kinase TKL protein kinase group TKL protein kinase STKR family TKL protein kinase STKR Type 1 subfamily
- - 2100-2100 - -
Enzyme Kinase Protein Kinase TK protein kinase group Tyrosine protein kinase Abl family
- 86-151 9-770 - -
Enzyme Kinase Protein Kinase TK protein kinase group Tyrosine protein kinase Alk family
- - 550-550 - -
Enzyme Kinase Protein Kinase TK protein kinase group Tyrosine protein kinase Axl family
- - 1400-1400 - -
Enzyme Kinase Protein Kinase TK protein kinase group Tyrosine protein kinase Csk family
- - 2500-3700 - -
Enzyme Kinase Protein Kinase TK protein kinase group Tyrosine protein kinase DDR family
- - 11-11 - -
Enzyme Kinase Protein Kinase TK protein kinase group Tyrosine protein kinase EGFR family
- 11-800 5-230 - 18
Enzyme Kinase Protein Kinase TK protein kinase group Tyrosine protein kinase Eph family
- - 1100-1900 - -
Enzyme Kinase Protein Kinase TK protein kinase group Tyrosine protein kinase FGFR family
- 2310-6000 240-6900 - 47
Enzyme Kinase Protein Kinase TK protein kinase group Tyrosine protein kinase Met family
- 3370 4100-5700 - -
Enzyme Kinase Protein Kinase TK protein kinase group Tyrosine protein kinase PDGFR family
- 477-1100 34-2000 - -
Enzyme Kinase Protein Kinase TK protein kinase group Tyrosine protein kinase Ret family
- 9-2597 14-34 - -
Enzyme Kinase Protein Kinase TK protein kinase group Tyrosine protein kinase Src family Tyrosine protein kinase Srm
- - 1900-1900 - -
Enzyme Kinase Protein Kinase TK protein kinase group Tyrosine protein kinase Src family
- 44-186 110-710 - -
Enzyme Kinase Protein Kinase TK protein kinase group Tyrosine protein kinase Tec family
- - 3700-3700 - -
Enzyme Kinase Protein Kinase TK protein kinase group Tyrosine protein kinase Tie family
- 567-2500 1000-3600 - -
Enzyme Kinase Protein Kinase TK protein kinase group Tyrosine protein kinase VEGFR family
- 9-5981 300-1100 - 96
Membrane receptor
- - 76 - -
Other cytosolic protein
- 400 - - -
Structural protein
- - 480 - -

Indications

Mesh Heading Maximum Phase Mesh ID Reference
Thyroid Neoplasms 4 D013964 ClinicalTrials
Neoplasms 4 D009369 ClinicalTrials
Thyroid Neoplasms 4 D013964 ClinicalTrials
Thyroid Neoplasms 4 D013964 ClinicalTrials
Carcinoma, Medullary 4 D018276 ClinicalTrials
Neoplasms 4 D009369 ClinicalTrials
Carcinoma, Non-Small-Cell Lung 3 D002289 ClinicalTrials
Colorectal Neoplasms 2 D015179 ClinicalTrials
Oligodendroglioma 2 D009837 ClinicalTrials
Small Cell Lung Carcinoma 2 D055752 ClinicalTrials
Multiple Myeloma 2 D009101 ClinicalTrials
Astrocytoma 2 D001254 ClinicalTrials
Oligodendroglioma 2 D009837 ClinicalTrials
Breast Neoplasms 2 D001943 ClinicalTrials
Head and Neck Neoplasms 2 D006258 ClinicalTrials
Carcinoma, Verrucous 2 D018289 ClinicalTrials
Gliosarcoma 2 D018316 ClinicalTrials
Colorectal Neoplasms 2 D015179 ClinicalTrials
Adenocarcinoma, Follicular 2 D018263 ClinicalTrials
Prostatic Neoplasms, Castration-Resistant 2 D064129 ClinicalTrials
Pancreatic Neoplasms 2 D010190 ClinicalTrials
Prostatic Neoplasms 2 D011471 ClinicalTrials
Gastrointestinal Stromal Tumors 2 D046152 ClinicalTrials
Carcinoma, Hepatocellular 2 D006528 ClinicalTrials
Carcinoma, Renal Cell 2 D002292 ClinicalTrials
Carcinoma, Squamous Cell 2 D002294 ClinicalTrials
Leukemia, Myeloid, Acute 2 D015470 ClinicalTrials
Breast Neoplasms 2 D001943 ClinicalTrials
Ovarian Neoplasms 2 D010051 ClinicalTrials
Mesothelioma 2 D008654 ClinicalTrials
Ureteral Neoplasms 2 D014516 ClinicalTrials
Lung Neoplasms 2 D008175 ClinicalTrials
Stomach Neoplasms 2 D013274 ClinicalTrials
Neoplasm Metastasis 2 D009362 ClinicalTrials
Stomach Neoplasms 2 D013274 ClinicalTrials
Urinary Bladder Neoplasms 2 D001749 ClinicalTrials
Peritoneal Neoplasms 2 D010534 ClinicalTrials
Fallopian Tube Neoplasms 2 D005185 ClinicalTrials
Kidney Neoplasms 2 D007680 ClinicalTrials
Urethral Neoplasms 2 D014523 ClinicalTrials
Esophageal Neoplasms 1 D004938 ClinicalTrials
Diffuse Intrinsic Pontine Glioma 1 D000080443 ClinicalTrials
Central Nervous System Neoplasms 1 D016543 ClinicalTrials
Rectal Neoplasms 1 D012004 ClinicalTrials
Glioblastoma 1 D005909 ClinicalTrials
Neuroblastoma 1 D009447 ClinicalTrials
Glioma 1 D005910 ClinicalTrials

Related Entries

Scaffolds

Side Effects from Label

Side effects Relative Frequency (%) Labels
Gastrointestinal disorders Colitis 57.0
Gastrointestinal disorders Diarrhoea 57.0
Gastrointestinal disorders Diarrhoea 56.3
Skin and subcutaneous tissue disorders Dermatitis 53.0
Skin and subcutaneous tissue disorders Rash 53.0
Skin and subcutaneous tissue disorders Dermatitis 45.0
Skin and subcutaneous tissue disorders Rash 45.0
Skin and subcutaneous tissue disorders Acne 35.0
Skin and subcutaneous tissue disorders Dermatitis acneiform 35.0
Gastrointestinal disorders Nausea 33.3
Vascular disorders Hypertension 33.0
Vascular disorders Hypertensive crisis 33.0
Vascular disorders Malignant hypertension 33.0
Gastrointestinal disorders Nausea 33.0
Vascular disorders Hypertension 31.6
Gastrointestinal disorders Colitis
Gastrointestinal disorders Diarrhoea
Gastrointestinal disorders Diarrhoea
Nervous system disorders Headache 26.0
Nervous system disorders Headache 25.5
General disorders and administration site conditions Asthenia 24.0
General disorders and administration site conditions Fatigue 24.0
Investigations Amylase increased 23.8
General disorders and administration site conditions Asthenia 23.8
General disorders and administration site conditions Fatigue 23.8
General disorders and administration site conditions Asthenia
General disorders and administration site conditions Fatigue
General disorders and administration site conditions Asthenia
General disorders and administration site conditions Fatigue
Infections and infestations Upper respiratory tract infection 23.0
General disorders and administration site conditions Decreased appetite 21.2
Gastrointestinal disorders Abdominal pain 21.0
General disorders and administration site conditions Decreased appetite 21.0
Gastrointestinal disorders Gastrointestinal pain 21.0
Skin and subcutaneous tissue disorders Acne 19.9
Gastrointestinal disorders Nausea
Gastrointestinal disorders Nausea
Infections and infestations Upper respiratory tract infection
Skin and subcutaneous tissue disorders Dermatitis acneiform 15.2
Skin and subcutaneous tissue disorders Dry skin 15.2
Skin and subcutaneous tissue disorders Dry skin 15.0
Gastrointestinal disorders Vomiting 15.0
General disorders and administration site conditions Asthenia 14.7
Gastrointestinal disorders Vomiting 14.7
Gastrointestinal disorders Abdominal pain 14.3
Investigations Electrocardiogram QT prolonged 14.3
Gastrointestinal disorders Gastrointestinal pain 14.3
Investigations Electrocardiogram QT prolonged 14.0
Skin and subcutaneous tissue disorders Photosensitivity reaction 13.4
Nervous system disorders Insomnia 13.0
Skin and subcutaneous tissue disorders Photosensitivity reaction 13.0
General disorders and administration site conditions Decreased appetite
Investigations Haemoglobin increased 12.1
General disorders and administration site conditions Decreased appetite
Skin and subcutaneous tissue disorders Dermatitis
Skin and subcutaneous tissue disorders Rash
Infections and infestations Nasopharyngitis 11.3
General disorders and administration site conditions Asthenia
Skin and subcutaneous tissue disorders Dermatitis
Skin and subcutaneous tissue disorders Rash
Gastrointestinal disorders Abdominal pain
Gastrointestinal disorders Colitis 11.0
Gastrointestinal disorders Diarrhoea 11.0
Gastrointestinal disorders Dyspepsia 11.0
Gastrointestinal disorders Gastrointestinal pain
Metabolism and nutrition disorders Hypocalcaemia 11.0
Skin and subcutaneous tissue disorders Pruritus 11.0
Respiratory, thoracic and mediastinal disorders Cough 10.8
Gastrointestinal disorders Dyspepsia 10.8
Metabolism and nutrition disorders Hypocalcaemia 10.8
Skin and subcutaneous tissue disorders Pruritus 10.8
Investigations Weight decreased 10.4
Respiratory, thoracic and mediastinal disorders Cough
Nervous system disorders Insomnia
Psychiatric disorders Depression 10.0
Renal and urinary disorders Proteinuria 10.0
Investigations Protein urine present 10.0
Nervous system disorders Headache
Infections and infestations Nasopharyngitis
Investigations Weight decreased
Gastrointestinal disorders Dry mouth 9.0
Nervous system disorders Headache
Vascular disorders Hypertension 9.0
Vascular disorders Hypertensive crisis 9.0
Vascular disorders Malignant hypertension 9.0
Skin and subcutaneous tissue disorders Nail disorder 9.0
Eye disorders Vision blurred 9.0
Skin and subcutaneous tissue disorders Alopecia 8.0
Gastrointestinal disorders Dysgeusia 8.0
Investigations Electrocardiogram QT prolonged 8.0
Gastrointestinal disorders Vomiting
Skin and subcutaneous tissue disorders Acne
Skin and subcutaneous tissue disorders Dermatitis acneiform
Gastrointestinal disorders Vomiting
General disorders and administration site conditions Asthenia 6.0
General disorders and administration site conditions Fatigue 6.0
Endocrine disorders Hypothyroidism 6.0
Musculoskeletal and connective tissue disorders Muscle spasms 6.0
Gastrointestinal disorders Abdominal pain
Skin and subcutaneous tissue disorders Acne
Skin and subcutaneous tissue disorders Dry skin
Gastrointestinal disorders Gastrointestinal pain
Vascular disorders Hypertension
Investigations Amylase increased 5.0
Skin and subcutaneous tissue disorders Dermatitis 5.0
Skin and subcutaneous tissue disorders Dry skin
Vascular disorders Hypertension
Vascular disorders Hypertensive crisis
Vascular disorders Malignant hypertension
Skin and subcutaneous tissue disorders Rash 5.0
Gastrointestinal disorders Dyspepsia
Skin and subcutaneous tissue disorders Pruritus
General disorders and administration site conditions Decreased appetite 4.0
Gastrointestinal disorders Dyspepsia
Skin and subcutaneous tissue disorders Pruritus
Metabolism and nutrition disorders Hypocalcaemia
Gastrointestinal disorders Abdominal pain 3.0
Psychiatric disorders Depression
Gastrointestinal disorders Dry mouth
Gastrointestinal disorders Dysgeusia
Gastrointestinal disorders Gastrointestinal pain 3.0
Metabolism and nutrition disorders Hypocalcaemia
Gastrointestinal disorders Diarrhoea 2.16
Infections and infestations Pneumonia 2.16
Skin and subcutaneous tissue disorders Dermatitis acneiform
Gastrointestinal disorders Colitis
Psychiatric disorders Depression 2.0
Gastrointestinal disorders Diarrhoea
Metabolism and nutrition disorders Hypocalcaemia 2.0
Skin and subcutaneous tissue disorders Photosensitivity reaction 2.0
Renal and urinary disorders Proteinuria
Investigations Protein urine present
General disorders and administration site conditions Decreased appetite 1.73
Vascular disorders Hypertensive crisis 1.73
General disorders and administration site conditions Asthenia 1.7
Skin and subcutaneous tissue disorders Dermatitis 1.7
Skin and subcutaneous tissue disorders Rash 1.7
Gastrointestinal disorders Abdominal pain 1.3
Psychiatric disorders Depression 1.3
Gastrointestinal disorders Gastrointestinal pain 1.3
Endocrine disorders Hypercalcaemia 1.3
Vascular disorders Hypertension 1.3
Infections and infestations Urinary tract infection 1.3
Investigations Electrocardiogram QT prolonged
Skin and subcutaneous tissue disorders Acne 1.0
General disorders and administration site conditions Asthenia
Skin and subcutaneous tissue disorders Dermatitis acneiform 1.0
Investigations Electrocardiogram QT prolonged
General disorders and administration site conditions Fatigue
Gastrointestinal disorders Gastroenteritis 1.0
Gastrointestinal disorders Gastrointestinal haemorrhage 1.0
Nervous system disorders Headache 1.0
Vascular disorders Hypertension
Vascular disorders Hypertensive crisis
Vascular disorders Malignant hypertension
Musculoskeletal and connective tissue disorders Muscle spasms
Gastrointestinal disorders Nausea 1.0
Skin and subcutaneous tissue disorders Pruritus 1.0
Eye disorders Vision blurred
Gastrointestinal disorders Vomiting 1.0
Gastrointestinal disorders Appendicitis 0.9
General disorders and administration site conditions Asthenia 0.9
Investigations Blood creatinine increased 0.9
Investigations Body temperature increased 0.9
Infections and infestations Bronchitis 0.9
Metabolism and nutrition disorders Dehydration 0.9
Gastrointestinal disorders Diarrhoea 0.9
Gastrointestinal disorders Diverticulitis 0.9
Gastrointestinal disorders Dysphagia 0.9
General disorders and administration site conditions Fatigue 0.9
Vascular disorders Hypertension 0.9
Metabolism and nutrition disorders Hypocalcaemia 0.9
Metabolism and nutrition disorders Hypokalaemia 0.9
Nervous system disorders Loss of consciousness 0.9
Renal and urinary disorders Nephrolithiasis 0.9
Skin and subcutaneous tissue disorders Photosensitivity reaction 0.9
Infections and infestations Pneumonia 0.9
Infections and infestations Sepsis 0.9
Nervous system disorders Transient ischaemic attack 0.9
Gastrointestinal disorders Vomiting 0.9
Gastrointestinal disorders Abdominal wall abscess 0.4
Nervous system disorders Altered state of consciousness 0.4
Renal and urinary disorders Anuria 0.4
Cardiac disorders Arrhythmia 0.4
General disorders and administration site conditions Asthenia 0.4
Cardiac disorders Atrial fibrillation 0.4
Psychiatric disorders Bipolar disorder 0.4
Psychiatric disorders Bipolar I disorder 0.4
Musculoskeletal and connective tissue disorders Bone cancer metastatic 0.4
Cardiac disorders Bradycardia 0.4
Injury, poisoning and procedural complications Brain oedema 0.4
Immune system disorders Bronchospasm 0.4
Calculus ureteric 0.4
Cardiac disorders Cardiac failure acute 0.4
Nervous system disorders Cerebral ischaemia 0.4
Cardiac disorders Chest pain 0.4
Hepatobiliary disorders Cholecystitis 0.4
Hepatobiliary disorders Cholelithiasis 0.4
Respiratory, thoracic and mediastinal disorders Chylothorax 0.4
Gastrointestinal disorders Colitis 0.4
Nervous system disorders Depressed level of consciousness 0.4
Skin and subcutaneous tissue disorders Dermatitis 0.4
Product issues Device occlusion 0.4
Cardiac disorders Dyspnoea 0.4
General disorders and administration site conditions Fatigue 0.4
Gastrointestinal disorders Gastritis 0.4
Gastrointestinal disorders Gastrointestinal haemorrhage 0.4
General disorders and administration site conditions General physical health deterioration 0.4
Eye disorders Glaucoma 0.4
Cardiac disorders Haemoptysis 0.4
Endocrine disorders Hypoglycaemia 0.4
Metabolism and nutrition disorders Hyponatraemia 0.4
Gastrointestinal disorders Ileus 0.4
Infected bites 0.4
Injury, poisoning and procedural complications Joint injury 0.4
Infections and infestations Laryngitis 0.4
Vascular disorders Malignant hypertension 0.4
Metabolism and nutrition disorders Malnutrition 0.4
General disorders and administration site conditions Mucosal inflammation 0.4
Vascular disorders Pelvic venous thrombosis 0.4
Cardiac disorders Pericarditis 0.4
Nervous system disorders Peripheral sensorimotor neuropathy 0.4
Gastrointestinal disorders Peritonitis 0.4
Gastrointestinal disorders Pneumatosis intestinalis 0.4
Respiratory, thoracic and mediastinal disorders Pneumonia aspiration 0.4
Skin and subcutaneous tissue disorders Pruritus 0.4
Infections and infestations Pyelonephritis 0.4
Skin and subcutaneous tissue disorders Rash 0.4
Renal and urinary disorders Renal colic 0.4
Renal and urinary disorders Renal failure 0.4
Respiratory, thoracic and mediastinal disorders Respiratory arrest 0.4
Metabolism and nutrition disorders Respiratory failure 0.4
Skin and subcutaneous tissue disorders Skin ulcer 0.4
Gastrointestinal disorders Small intestinal perforation 0.4
Infections and infestations Staphylococcal bacteraemia 0.4
Infections and infestations Staphylococcal infection 0.4
Infections and infestations Tracheitis 0.4
Renal and urinary disorders Tubulointerstitial nephritis 0.4
Vascular disorders Vena cava thrombosis 0.4
Injury, poisoning and procedural complications Venomous bite 0.4
Gastrointestinal disorders Viral diarrhoea 0.4
Eye disorders Vision blurred 0.4

Adverse Reactions

SOC By Demographic Distribution
System Organ Classification (SOC)
Relative Frequency (%)
Gastrointestinal disorders
11.82
General disorders and administration site conditions
11.72
Respiratory, thoracic and mediastinal disorders
10.71
Skin and subcutaneous tissue disorders
10.0
Infections and infestations
8.59
Investigations
8.02
Musculoskeletal and connective tissue disorders
5.6
Nervous system disorders
5.33
Metabolism and nutrition disorders
3.95
Vascular disorders
3.93
Eye disorders
3.15
Injury, poisoning and procedural complications
2.75
Cardiac disorders
2.54
Renal and urinary disorders
2.31

Cross References

Resources Reference
CAS NUMBER 443913-73-3
ChEBI 49960
ChEMBL CHEMBL24828
DrugBank DB05294
DrugCentral 4178
EPA CompTox DTXSID1046681
FDA SRS YO460OQ37K
Guide to Pharmacology 5717
PDB ZD6
PharmGKB PA166118341
PubChem 3081361
SureChEMBL SCHEMBL9044
ZINC ZINC000053683345
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