| Synonyms: | |
| Status: | Approved |
| Entry Type: | Small molecule |
| Molecule Category: | UNKNOWN |
| ATC: | M09AX03 |
| UNII: | K16AME9I3V |
Structure
| InChI Key | OOUGLTULBSNHNF-UHFFFAOYSA-N |
|---|---|
| Smile | |
| InChI |
|
Physicochemical Descriptors
| Property Name | Value |
|---|---|
| Molecular Formula | C15H9FN2O3 |
| Molecular Weight | 284.25 |
| AlogP | 3.24 |
| Hydrogen Bond Acceptor | 4.0 |
| Hydrogen Bond Donor | 1.0 |
| Number of Rotational Bond | 3.0 |
| Polar Surface Area | 76.22 |
| Molecular species | ACID |
| Aromatic Rings | 3.0 |
| Heavy Atoms | 21.0 |
Pharmacology
| Action | Mechanism of Action | Reference |
|---|---|---|
| MODULATOR | 80S Ribosome modulator |
| Targets | EC50(nM) | IC50(nM) | Kd(nM) | Ki(nM) | Inhibition(%) | |
|---|---|---|---|---|---|---|
|
Enzyme
Oxidoreductase
|
- | - | 199.53-200 | - | 94 | |
|
Enzyme
Transferase
|
- | - | - | - | 3.095-31.18 | |
|
Epigenetic regulator
Eraser
Histone deacetylase
HDAC class IIb
|
- | 300.9 | - | - | 99.8-104.52 |
Indications
| Mesh Heading | Maximum Phase | Mesh ID | Reference |
|---|---|---|---|
| Muscular Dystrophy, Duchenne | 4 | D020388 | ClinicalTrials |
| Cystic Fibrosis | 3 | D003550 | ClinicalTrials |
| Aniridia | 2 | D015783 | ClinicalTrials |
| Hemophilia A | 2 | D006467 | ClinicalTrials |
| Epilepsy | 2 | D004827 | ClinicalTrials |
| Hemophilia B | 2 | D002836 | ClinicalTrials |
Related Entries
Scaffolds
Cross References
| Resources | Reference |
|---|---|
| CAS NUMBER | 775304-57-9 |
| ChEBI | 94805 |
| ChEMBL | CHEMBL256997 |
| DrugBank | DB05016 |
| DrugCentral | 4872 |
| EPA CompTox | DTXSID5046776 |
| FDA SRS | K16AME9I3V |
| Guide to Pharmacology | 7341 |
| PDB | JBF |
| PharmGKB | PA166151864 |
| PubChem | 11219835 |
| SureChEMBL | SCHEMBL60614 |
| ZINC | ZINC000013831791 |
CONTENTS