BLONANSERIN

Search structure
Synonyms:
Status: Approved
Entry Type: Small molecule
Molecule Category: UNKNOWN
UNII: AQ316B4F8C

Structure
InChI Key XVGOZDAJGBALKS-UHFFFAOYSA-N
Smile CCN1CCN(c2cc(-c3ccc(F)cc3)c3c(n2)CCCCCC3)CC1
InChI
InChI=1S/C23H30FN3/c1-2-26-13-15-27(16-14-26)23-17-21(18-9-11-19(24)12-10-18)20-7-5-3-4-6-8-22(20)25-23/h9-12,17H,2-8,13-16H2,1H3

Physicochemical Descriptors

Property Name Value
Molecular Formula C23H30FN3
Molecular Weight 367.51
AlogP 4.69
Hydrogen Bond Acceptor 3.0
Hydrogen Bond Donor 0.0
Number of Rotational Bond 3.0
Polar Surface Area 19.37
Molecular species NEUTRAL
Aromatic Rings 2.0
Heavy Atoms 27.0

Pharmacology

Action Mechanism of Action Reference
ANTAGONIST Dopamine D2 receptor antagonist PubMed PubMed
Primary Target
5-HT2A receptor
D2 receptor
Targets EC50(nM) IC50(nM) Kd(nM) Ki(nM) Inhibition(%)
Membrane receptor Family A G protein-coupled receptor Small molecule receptor (family A GPCR) Monoamine receptor Dopamine receptor
- - - 0 -
Membrane receptor Family A G protein-coupled receptor Small molecule receptor (family A GPCR) Monoamine receptor Serotonin receptor
- - - 1 -

Indications

Mesh Heading Maximum Phase Mesh ID Reference
Schizophrenia 3 D012559 ClinicalTrials

Related Entries

Scaffolds

Cross References

Resources Reference
CAS NUMBER 132810-10-7
ChEBI 31296
ChEMBL CHEMBL178803
DrugBank DB09223
DrugCentral 388
EPA CompTox DTXSID7048790
FDA SRS AQ316B4F8C
Guide to Pharmacology 7670
PubChem 125564
SureChEMBL SCHEMBL119669
ZINC ZINC000000597434
CONTENTS