| Synonyms: | |
| Status: | Phase 1 |
| Entry Type: | Small molecule |
| Molecule Category: | UNKNOWN |
| UNII: | X8BW0MQ5PI |
Structure
| InChI Key | KGERZPVQIRYWRK-GDLZYMKVSA-N |
|---|---|
| Smile | |
| InChI |
|
Physicochemical Descriptors
| Property Name | Value |
|---|---|
| Molecular Formula | C30H33N5O2 |
| Molecular Weight | 495.63 |
| AlogP | 5.54 |
| Hydrogen Bond Acceptor | 7.0 |
| Hydrogen Bond Donor | 1.0 |
| Number of Rotational Bond | 5.0 |
| Polar Surface Area | 77.99 |
| Molecular species | NEUTRAL |
| Aromatic Rings | 5.0 |
| Heavy Atoms | 37.0 |
Pharmacology
| Action | Mechanism of Action | Reference |
|---|---|---|
| INHIBITOR | Bromodomain and extra-terminal motif (BET) inhibitor | Other |
Indications
| Mesh Heading | Maximum Phase | Mesh ID | Reference |
|---|---|---|---|
| Lymphoma | 1 | D008223 | ClinicalTrials |
| Neoplasms | 1 | D009369 | ClinicalTrials |
| Primary Myelofibrosis | 1 | D055728 | ClinicalTrials |
Related Entries
Scaffolds
Cross References
| Resources | Reference |
|---|---|
| CAS NUMBER | 1800340-40-2 |
| ChEMBL | CHEMBL4297458 |
| DrugBank | DB15435 |
| FDA SRS | X8BW0MQ5PI |
| PubChem | 118196485 |
| SureChEMBL | SCHEMBL16861831 |
CONTENTS