CEDAZURIDINE

Search structure
Synonyms:
Status: Approved (2020)
Entry Type: Small molecule
Molecule Category: UNKNOWN
UNII: 39IS23Q1EW

Structure
InChI Key VUDZSIYXZUYWSC-DBRKOABJSA-N
Smile O=C1N[C@H](O)CCN1[C@@H]1O[C@H](CO)[C@@H](O)C1(F)F
InChI
InChI=1S/C9H14F2N2O5/c10-9(11)6(16)4(3-14)18-7(9)13-2-1-5(15)12-8(13)17/h4-7,14-16H,1-3H2,(H,12,17)/t4-,5-,6-,7-/m1/s1

Physicochemical Descriptors

Property Name Value
Molecular Formula C9H14F2N2O5
Molecular Weight 268.22
AlogP -1.57
Hydrogen Bond Acceptor 5.0
Hydrogen Bond Donor 4.0
Number of Rotational Bond 2.0
Polar Surface Area 102.26
Molecular species NEUTRAL
Aromatic Rings 0.0
Heavy Atoms 18.0

Pharmacology

Action Mechanism of Action Reference
INHIBITOR Cytidine deaminase inhibitor
Targets EC50(nM) IC50(nM) Kd(nM) Ki(nM) Inhibition(%)
Enzyme Hydrolase
- 400 - - -

Indications

Mesh Heading Maximum Phase Mesh ID Reference
Leukemia, Myeloid, Acute 2 D015470 ClinicalTrials
Lymphoma, T-Cell, Peripheral 1 D016411 ClinicalTrials
Prostatic Neoplasms 1 D011471 ClinicalTrials
Triple Negative Breast Neoplasms 1 D064726 ClinicalTrials
Carcinoma, Squamous Cell 1 D002294 ClinicalTrials
Leukemia 1 D007938 ClinicalTrials
Leukemia, Myeloid 1 D007951 ClinicalTrials
Mastocytosis, Systemic 1 D034721 ClinicalTrials
Neoplasms 1 D009369 ClinicalTrials

Related Entries

MCS

Cross References

Resources Reference
ChEMBL CHEMBL3237547
DrugBank DB15694
FDA SRS 39IS23Q1EW
Guide to Pharmacology 11101
PubChem 25267009
SureChEMBL SCHEMBL172256
ZINC ZINC000043205136
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