CISAPRIDE

Search structure
Synonyms:
Status: Approved (1993) Withdrawn (2000)
Entry Type: Small molecule
Molecule Category: UNKNOWN
ATC: A03FA02
UNII: UVL329170W

Structure
InChI Key DCSUBABJRXZOMT-UHFFFAOYSA-N
Smile COc1cc(N)c(Cl)cc1C(=O)NC1CCN(CCCOc2ccc(F)cc2)CC1OC
InChI
InChI=1S/C23H29ClFN3O4/c1-30-21-13-19(26)18(24)12-17(21)23(29)27-20-8-10-28(14-22(20)31-2)9-3-11-32-16-6-4-15(25)5-7-16/h4-7,12-13,20,22H,3,8-11,14,26H2,1-2H3,(H,27,29)

Physicochemical Descriptors

Property Name Value
Molecular Formula C23H29ClFN3O4
Molecular Weight 465.95
AlogP 3.36
Hydrogen Bond Acceptor 6.0
Hydrogen Bond Donor 2.0
Number of Rotational Bond 9.0
Polar Surface Area 86.05
Molecular species NEUTRAL
Aromatic Rings 2.0
Heavy Atoms 32.0

Pharmacology

Action Mechanism of Action Reference
AGONIST Serotonin 4 (5-HT4) receptor agonist DailyMed Wikipedia
Primary Target
5-HT4 receptor
Targets EC50(nM) IC50(nM) Kd(nM) Ki(nM) Inhibition(%)
Ion channel Ligand-gated ion channel 5HT3 receptor
- 900 63-316 95-134 -
Ion channel Other ion channel Pore-forming toxins (proteins and peptides)
- - - - 11
Ion channel Voltage-gated ion channel Potassium channels Voltage-gated potassium channel
- 7-2690 - - 66-100
Ion channel Voltage-gated ion channel Voltage-gated calcium channel
- 16000-46900 - - -
Ion channel Voltage-gated ion channel Voltage-gated sodium channel
- 14700 - - -
Membrane receptor Family A G protein-coupled receptor Small molecule receptor (family A GPCR) Monoamine receptor Adrenergic receptor
- 30-30 - 30 -
Membrane receptor Family A G protein-coupled receptor Small molecule receptor (family A GPCR) Monoamine receptor Dopamine receptor
- 390-680 - 227-227 -
Membrane receptor Family A G protein-coupled receptor Small molecule receptor (family A GPCR) Monoamine receptor Serotonin receptor
55-55 6-6 - 14-20 -

Indications

Mesh Heading Maximum Phase Mesh ID Reference

Related Entries

MCS

Scaffolds

Cross References

Resources Reference
CAS NUMBER 81098-60-4
ChEBI 95129
ChEMBL CHEMBL1729
DrugCentral 660
EPA CompTox DTXSID3022825
FDA SRS UVL329170W
Guide to Pharmacology 240
KEGG C06910
PharmGKB PA449011
PubChem 6917698
SureChEMBL SCHEMBL16131
CONTENTS