CLAVULANATE POTASSIUM

Search structure
Synonyms:
Status: Approved (1984)
Entry Type: Small molecule
Molecule Category: Parent
UNII: Q42OMW3AT8

Structure
InChI Key ABVRVIZBZKUTMK-JSYANWSFSA-M
Smile O=C([O-])[C@H]1/C(=C/CO)O[C@@H]2CC(=O)N21.[K+]
InChI
InChI=1S/C8H9NO5.K/c10-2-1-4-7(8(12)13)9-5(11)3-6(9)14-4;/h1,6-7,10H,2-3H2,(H,12,13);/q;+1/p-1/b4-1-;/t6-,7-;/m1./s1

Physicochemical Descriptors

Property Name Value
Molecular Formula C8H8KNO5
Molecular Weight 237.25
AlogP -1.1
Hydrogen Bond Acceptor 4.0
Hydrogen Bond Donor 2.0
Number of Rotational Bond 2.0
Polar Surface Area 87.07
Molecular species ACID
Aromatic Rings 0.0
Heavy Atoms 14.0

Pharmacology

Action Mechanism of Action Reference
INHIBITOR Bacterial beta-lactamase TEM inhibitor
Targets EC50(nM) IC50(nM) Kd(nM) Ki(nM) Inhibition(%)
Enzyme Hydrolase
- 330000-539000 - - -

Indications

Mesh Heading Maximum Phase Mesh ID Reference
Urinary Tract Infections 4 D014552 ClinicalTrials
Respiratory Tract Infections 4 D012141 ClinicalTrials
Otitis Media 4 D010033 ClinicalTrials
Pyelonephritis 3 D011704 ClinicalTrials
Enterobacteriaceae Infections 3 D004756 ClinicalTrials
Mastitis 2 D008413 ClinicalTrials
Tuberculosis 2 D014376 ClinicalTrials
Periapical Periodontitis 2 D010485 ClinicalTrials
Sepsis 1 D018805 ClinicalTrials

Related Entries

MCS

Mixture
Mixture

Cross References

Resources Reference
ChEBI 85264
ChEMBL CHEMBL1003
EPA CompTox DTXSID60210067
FDA SRS Q42OMW3AT8
PubChem 23665591
SureChEMBL SCHEMBL203411
CONTENTS